rottlerin-941 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the rottlerin-941 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMOTL2 angiomotin like 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNT aryl hydrocarbon receptor nuclear translocator
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
C14ORF93 chromosome 14 open reading frame 93
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CEP164 centrosomal protein 164kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLGN calmegin
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CSNK1G1 casein kinase 1, gamma 1
CTAGE5 CTAGE family, member 5
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DBP D site of albumin promoter (albumin D-box) binding protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP10 dual specificity phosphatase 10
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GRB7 growth factor receptor-bound protein 7
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
INHBE inhibin, beta E
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MED6 mediator complex subunit 6
N4BP2L2 NEDD4 binding protein 2-like 2
NCAPH2 non-SMC condensin II complex, subunit H2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
OSGIN1 oxidative stress induced growth inhibitor 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
SAMD4A sterile alpha motif domain containing 4A
SGSH N-sulfoglucosamine sulfohydrolase
SH3BGR SH3 domain binding glutamate-rich protein
SH3BP2 SH3-domain binding protein 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMAD3 SMAD family member 3
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SQSTM1 sequestosome 1
SRCAP Snf2-related CREBBP activator protein
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STRN striatin, calmodulin binding protein
SWAP70 SWAP switching B-cell complex 70kDa subunit
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRA2A transformer 2 alpha homolog (Drosophila)
TRIB3 tribbles pseudokinase 3
TRIM36 tripartite motif containing 36
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VIPR2 vasoactive intestinal peptide receptor 2
ZNF165 zinc finger protein 165
ZNF329 zinc finger protein 329
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
ARMC7 armadillo repeat containing 7
ASB9 ankyrin repeat and SOCS box containing 9
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL9 B-cell CLL/lymphoma 9
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BMP4 bone morphogenetic protein 4
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C1ORF115 chromosome 1 open reading frame 115
C2ORF44 chromosome 2 open reading frame 44
C9ORF40 chromosome 9 open reading frame 40
CCNE1 cyclin E1
CCNE2 cyclin E2
CERK ceramide kinase
CHUK conserved helix-loop-helix ubiquitous kinase
CPTP ceramide-1-phosphate transfer protein
CROT carnitine O-octanoyltransferase
CTSV cathepsin V
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DTX4 deltex 4, E3 ubiquitin ligase
DUSP8 dual specificity phosphatase 8
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
E2F8 E2F transcription factor 8
EGLN3 egl-9 family hypoxia-inducible factor 3
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERCC6L excision repair cross-complementation group 6-like
FAM172A family with sequence similarity 172, member A
FAR2 fatty acyl CoA reductase 2
FMO4 flavin containing monooxygenase 4
FPGT fucose-1-phosphate guanylyltransferase
GCHFR GTP cyclohydrolase I feedback regulator
GHR growth hormone receptor
GINS3 GINS complex subunit 3 (Psf3 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLB1L2 galactosidase, beta 1-like 2
GPALPP1 GPALPP motifs containing 1
GPR137B G protein-coupled receptor 137B
GPR19 G protein-coupled receptor 19
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HPS6 Hermansky-Pudlak syndrome 6
HSPA2 heat shock 70kDa protein 2
ICK intestinal cell (MAK-like) kinase
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KDM5C lysine (K)-specific demethylase 5C
KIF3A kinesin family member 3A
KIFC1 kinesin family member C1
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LMNB1 lamin B1
LOC100287590 uncharacterized LOC100287590
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAGEH1 melanoma antigen family H1
MAP6D1 MAP6 domain containing 1
MAPKAP1 mitogen-activated protein kinase associated protein 1
MCM10 minichromosome maintenance complex component 10
METTL2B methyltransferase like 2B
MMP9 matrix metallopeptidase 9
MTERF1 mitochondrial transcription termination factor 1
MTHFSD methenyltetrahydrofolate synthetase domain containing
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAP1L2 nucleosome assembly protein 1-like 2
NPY1R neuropeptide Y receptor Y1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDZD8 PDZ domain containing 8
PER3 period circadian clock 3
PFDN6 prefoldin subunit 6
PGP phosphoglycolate phosphatase
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POTEKP POTE ankyrin domain family, member K, pseudogene
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RANBP6 RAN binding protein 6
RBL1 retinoblastoma-like 1
RBM12 RNA binding motif protein 12
RFWD3 ring finger and WD repeat domain 3
RIBC2 RIB43A domain with coiled-coils 2
SIRT2 sirtuin 2
SLC16A6 solute carrier family 16, member 6
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SOBP sine oculis binding protein homolog (Drosophila)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM110 transmembrane protein 110
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZMAT3 zinc finger, matrin-type 3
ZNF107 zinc finger protein 107
ZNF160 zinc finger protein 160
ZNF271P zinc finger protein 271, pseudogene
ZNF430 zinc finger protein 430
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721