rottlerin-914 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the rottlerin-914 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFAP1 actin filament associated protein 1
AK1 adenylate kinase 1
ANKRD6 ankyrin repeat domain 6
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APOM apolipoprotein M
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATN1 atrophin 1
ATRX alpha thalassemia/mental retardation syndrome X-linked
BAG4 BCL2-associated athanogene 4
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCAM basal cell adhesion molecule (Lutheran blood group)
BTD biotinidase
C1ORF54 chromosome 1 open reading frame 54
CA4 carbonic anhydrase IV
CCPG1 cell cycle progression 1
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLGN calmegin
CPPED1 calcineurin-like phosphoesterase domain containing 1
CUL9 cullin 9
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
EPHX2 epoxide hydrolase 2, cytoplasmic
FNDC3A fibronectin type III domain containing 3A
FOXO1 forkhead box O1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GFI1 growth factor independent 1 transcription repressor
GOLGA2 golgin A2
GRB10 growth factor receptor-bound protein 10
GSK3A glycogen synthase kinase 3 alpha
GSPT1 G1 to S phase transition 1
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HAMP hepcidin antimicrobial peptide
HIST1H3B histone cluster 1, H3b
HPR haptoglobin-related protein
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
IFIH1 interferon induced with helicase C domain 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INADL InaD-like (Drosophila)
ING4 inhibitor of growth family, member 4
INHBE inhibin, beta E
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA1109 KIAA1109
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LIMCH1 LIM and calponin homology domains 1
LPAR4 lysophosphatidic acid receptor 4
LRRC40 leucine rich repeat containing 40
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MOSPD3 motile sperm domain containing 3
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NLGN1 neuroligin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PACRG PARK2 co-regulated
PADI4 peptidyl arginine deiminase, type IV
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSPH phosphoserine phosphatase
RB1CC1 RB1-inducible coiled-coil 1
RGS12 regulator of G-protein signaling 12
RNF208 ring finger protein 208
RPL7 ribosomal protein L7
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRED2 sprouty-related, EVH1 domain containing 2
SRD5A3 steroid 5 alpha-reductase 3
ST20 suppressor of tumorigenicity 20
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STARD3 StAR-related lipid transfer (START) domain containing 3
STIM1 stromal interaction molecule 1
SUGP1 SURP and G patch domain containing 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TCTN2 tectonic family member 2
TMEM212 transmembrane protein 212
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WIPF1 WAS/WASL interacting protein family, member 1
ZFP69B ZFP69 zinc finger protein B
ZMYM5 zinc finger, MYM-type 5
ZNF365 zinc finger protein 365

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ACVR2B activin A receptor, type IIB
ADCY6 adenylate cyclase 6
ANO10 anoctamin 10
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGAP10 Rho GTPase activating protein 10
ARID4A AT rich interactive domain 4A (RBP1-like)
BAHD1 bromo adjacent homology domain containing 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C14ORF93 chromosome 14 open reading frame 93
CCNO cyclin O
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPO centromere protein O
CHKB choline kinase beta
CORO1A coronin, actin binding protein, 1A
CORT cortistatin
CRIP1 cysteine-rich protein 1 (intestinal)
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DENND1B DENN/MADD domain containing 1B
EFNA4 ephrin-A4
ETAA1 Ewing tumor-associated antigen 1
F8 coagulation factor VIII, procoagulant component
FBXO5 F-box protein 5
FCHSD2 FCH and double SH3 domains 2
FICD FIC domain containing
FMO4 flavin containing monooxygenase 4
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GHR growth hormone receptor
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H3G histone cluster 1, H3g
HLA-J major histocompatibility complex, class I, J (pseudogene)
IPP intracisternal A particle-promoted polypeptide
KCTD20 potassium channel tetramerization domain containing 20
KRT15 keratin 15, type I
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LZTR1 leucine-zipper-like transcription regulator 1
MAP1S microtubule-associated protein 1S
MAPK12 mitogen-activated protein kinase 12
MISP mitotic spindle positioning
MSX1 msh homeobox 1
MT1H metallothionein 1H
MVD mevalonate (diphospho) decarboxylase
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDE1 nudE neurodevelopment protein 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NLK nemo-like kinase
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
NR1H2 nuclear receptor subfamily 1, group H, member 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCBP4 poly(rC) binding protein 4
PCDHB3 protocadherin beta 3
PCYOX1 prenylcysteine oxidase 1
PGR progesterone receptor
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PMP22 peripheral myelin protein 22
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP6R3 protein phosphatase 6, regulatory subunit 3
PPT2 palmitoyl-protein thioesterase 2
PTGES2 prostaglandin E synthase 2
RASAL1 RAS protein activator like 1 (GAP1 like)
RBM14 RNA binding motif protein 14
SALL2 spalt-like transcription factor 2
SCN1B sodium channel, voltage gated, type I beta subunit
SETD6 SET domain containing 6
SH2D4A SH2 domain containing 4A
SLC12A9 solute carrier family 12, member 9
SLC35F6 solute carrier family 35, member F6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
TARP TCR gamma alternate reading frame protein
TEFM transcription elongation factor, mitochondrial
TM7SF3 transmembrane 7 superfamily member 3
TMC5 transmembrane channel-like 5
TMEM120B transmembrane protein 120B
TMEM121 transmembrane protein 121
TMEM62 transmembrane protein 62
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNIP1 TNFAIP3 interacting protein 1
TPST2 tyrosylprotein sulfotransferase 2
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
UBXN6 UBX domain protein 6
UNKL unkempt family zinc finger-like
VASH1 vasohibin 1
WBSCR16 Williams-Beuren syndrome chromosome region 16
ZC3H3 zinc finger CCCH-type containing 3
ZNF141 zinc finger protein 141
ZNF254 zinc finger protein 254
ZNF276 zinc finger protein 276
ZNF586 zinc finger protein 586
ZNF76 zinc finger protein 76
ZW10 zw10 kinetochore protein