rofecoxib-463 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the rofecoxib-463 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACAN aggrecan
ACRV1 acrosomal vesicle protein 1
ADTRP androgen-dependent TFPI-regulating protein
AFF1 AF4/FMR2 family, member 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AMT aminomethyltransferase
ASB13 ankyrin repeat and SOCS box containing 13
ASF1A anti-silencing function 1A histone chaperone
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
AVPR1B arginine vasopressin receptor 1B
BGN biglycan
BICD1 bicaudal D homolog 1 (Drosophila)
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAPN3 calpain 3, (p94)
CAV3 caveolin 3
CCSER2 coiled-coil serine-rich protein 2
CD53 CD53 molecule
CD8A CD8a molecule
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CELF2 CUGBP, Elav-like family member 2
CETN1 centrin, EF-hand protein, 1
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC11A C-type lectin domain family 11, member A
COQ3 coenzyme Q3 methyltransferase
CREB3L1 cAMP responsive element binding protein 3-like 1
CST4 cystatin S
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DTNA dystrobrevin, alpha
EXTL2 exostosin-like glycosyltransferase 2
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGF4 fibroblast growth factor 4
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GREB1L growth regulation by estrogen in breast cancer-like
HERC2P3 hect domain and RLD 2 pseudogene 3
HHIPL2 HHIP-like 2
ICAM1 intercellular adhesion molecule 1
IL10RA interleukin 10 receptor, alpha
IL13 interleukin 13
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IRF2 interferon regulatory factor 2
JAKMIP2 janus kinase and microtubule interacting protein 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KYNU kynureninase
LHX3 LIM homeobox 3
LOC647070 uncharacterized LOC647070
LOC729164 hCG1732469
LUZP4 leucine zipper protein 4
LY86 lymphocyte antigen 86
MAN1C1 mannosidase, alpha, class 1C, member 1
MED31 mediator complex subunit 31
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NCS1 neuronal calcium sensor 1
NRXN1 neurexin 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OASL 2'-5'-oligoadenylate synthetase-like
OR7A17 olfactory receptor, family 7, subfamily A, member 17
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PADI2 peptidyl arginine deiminase, type II
PIGR polymeric immunoglobulin receptor
PKNOX2 PBX/knotted 1 homeobox 2
PLAGL2 pleiomorphic adenoma gene-like 2
PLIN2 perilipin 2
PON3 paraoxonase 3
PSG3 pregnancy specific beta-1-glycoprotein 3
PSG6 pregnancy specific beta-1-glycoprotein 6
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRA protein tyrosine phosphatase, receptor type, A
RARB retinoic acid receptor, beta
RET ret proto-oncogene
RSL1D1 ribosomal L1 domain containing 1
SFTPB surfactant protein B
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
SYNGR1 synaptogyrin 1
SYT13 synaptotagmin XIII
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D16 TBC1 domain family, member 16
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TRIM14 tripartite motif containing 14
TSPYL2 TSPY-like 2
VWA5A von Willebrand factor A domain containing 5A
ZNF276 zinc finger protein 276
ZNF576 zinc finger protein 576

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALG9 ALG9, alpha-1,2-mannosyltransferase
ANKRD40 ankyrin repeat domain 40
ATXN2 ataxin 2
BLMH bleomycin hydrolase
BPHL biphenyl hydrolase-like (serine hydrolase)
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BTBD2 BTB (POZ) domain containing 2
C1ORF109 chromosome 1 open reading frame 109
C7ORF43 chromosome 7 open reading frame 43
CDK9 cyclin-dependent kinase 9
CLDN17 claudin 17
COL19A1 collagen, type XIX, alpha 1
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CRIP1 cysteine-rich protein 1 (intestinal)
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DLK2 delta-like 2 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYD dihydropyrimidine dehydrogenase
EDC4 enhancer of mRNA decapping 4
EFNA1 ephrin-A1
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ESM1 endothelial cell-specific molecule 1
ETV4 ets variant 4
FAF1 Fas (TNFRSF6) associated factor 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGD6 FYVE, RhoGEF and PH domain containing 6
FGF6 fibroblast growth factor 6
GBAP1 glucosidase, beta, acid pseudogene 1
GLRA2 glycine receptor, alpha 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HOXA4 homeobox A4
HP1BP3 heterochromatin protein 1, binding protein 3
IL25 interleukin 25
JRKL JRK-like
JUNB jun B proto-oncogene
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KDR kinase insert domain receptor
KIFC1 kinesin family member C1
KRI1 KRI1 homolog (S. cerevisiae)
LAMP3 lysosomal-associated membrane protein 3
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LYPD3 LY6/PLAUR domain containing 3
MAGT1 magnesium transporter 1
MED9 mediator complex subunit 9
MEIS3P1 Meis homeobox 3 pseudogene 1
MON1B MON1 secretory trafficking family member B
MTERF4 mitochondrial transcription termination factor 4
MTG1 mitochondrial ribosome-associated GTPase 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYL12B myosin, light chain 12B, regulatory
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
NTSR1 neurotensin receptor 1 (high affinity)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PISD phosphatidylserine decarboxylase
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLM polymerase (DNA directed), mu
POTEKP POTE ankyrin domain family, member K, pseudogene
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRSS50 protease, serine, 50
PTBP2 polypyrimidine tract binding protein 2
RAD54L RAD54-like (S. cerevisiae)
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RPE ribulose-5-phosphate-3-epimerase
SARS2 seryl-tRNA synthetase 2, mitochondrial
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3D21 SH3 domain containing 21
SH3GL1 SH3-domain GRB2-like 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5
SMYD5 SMYD family member 5
SNX10 sorting nexin 10
SSNA1 Sjogren syndrome nuclear autoantigen 1
STXBP3 syntaxin binding protein 3
TET3 tet methylcytosine dioxygenase 3
THOC6 THO complex 6
TLN1 talin 1
TMEM127 transmembrane protein 127
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAPPC11 trafficking protein particle complex 11
TRAPPC12 trafficking protein particle complex 12
TRIM58 tripartite motif containing 58
TSKU tsukushi, small leucine rich proteoglycan
TSSC4 tumor suppressing subtransferable candidate 4
UBA3 ubiquitin-like modifier activating enzyme 3
UBXN6 UBX domain protein 6
XPA xeroderma pigmentosum, complementation group A
YPEL1 yippee-like 1 (Drosophila)
ZNF189 zinc finger protein 189
ZNF324 zinc finger protein 324