rofecoxib-371 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the rofecoxib-371 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADAM20 ADAM metallopeptidase domain 20
AGMAT agmatine ureohydrolase (agmatinase)
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C2 aldo-keto reductase family 1, member C2
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALOX5 arachidonate 5-lipoxygenase
APOA1 apolipoprotein A-I
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATG2A autophagy related 2A
AXIN1 axin 1
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
C19ORF66 chromosome 19 open reading frame 66
C1ORF54 chromosome 1 open reading frame 54
C20ORF27 chromosome 20 open reading frame 27
CA12 carbonic anhydrase XII
CALHM2 calcium homeostasis modulator 2
CAMKV CaM kinase-like vesicle-associated
CAV3 caveolin 3
CDC42 cell division cycle 42
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CECR1 cat eye syndrome chromosome region, candidate 1
CLEC1B C-type lectin domain family 1, member B
CLIC5 chloride intracellular channel 5
CPN2 carboxypeptidase N, polypeptide 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYB561 cytochrome b561
DIO2 deiodinase, iodothyronine, type II
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
ELP6 elongator acetyltransferase complex subunit 6
FGF4 fibroblast growth factor 4
FGFR1 fibroblast growth factor receptor 1
FNDC3A fibronectin type III domain containing 3A
FOXA1 forkhead box A1
GAS8-AS1 GAS8 antisense RNA 1
GDF11 growth differentiation factor 11
GNL1 guanine nucleotide binding protein-like 1
GPR153 G protein-coupled receptor 153
GRB7 growth factor receptor-bound protein 7
GRK5 G protein-coupled receptor kinase 5
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
ICAM2 intercellular adhesion molecule 2
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL1RN interleukin 1 receptor antagonist
IRGQ immunity-related GTPase family, Q
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
LINC00574 long intergenic non-protein coding RNA 574
LOC729164 hCG1732469
LRRC37A3 leucine rich repeat containing 37, member A3
LY6G6D lymphocyte antigen 6 complex, locus G6D
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCF2L MCF.2 cell line derived transforming sequence-like
MST1 macrophage stimulating 1
MT4 metallothionein 4
MYL10 myosin, light chain 10, regulatory
MYT1 myelin transcription factor 1
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OMG oligodendrocyte myelin glycoprotein
PAX1 paired box 1
PDCD2 programmed cell death 2
PDGFB platelet-derived growth factor beta polypeptide
PKN1 protein kinase N1
PLD2 phospholipase D2
PRDX2 peroxiredoxin 2
PTGES prostaglandin E synthase
RAB11B RAB11B, member RAS oncogene family
RAB15 RAB15, member RAS oncogene family
RIMS2 regulating synaptic membrane exocytosis 2
RNF121 ring finger protein 121
RPL13 ribosomal protein L13
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SH3BP2 SH3-domain binding protein 2
SIDT2 SID1 transmembrane family, member 2
SIGLEC5 sialic acid binding Ig-like lectin 5
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPN sialophorin
SRSF1 serine/arginine-rich splicing factor 1
STXBP6 syntaxin binding protein 6 (amisyn)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TESK2 testis-specific kinase 2
TLR6 toll-like receptor 6
TNF tumor necrosis factor
TNK2 tyrosine kinase, non-receptor, 2
TRD T cell receptor delta locus
TRMT61A tRNA methyltransferase 61A
TUBA4B tubulin, alpha 4b
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
ZNF473 zinc finger protein 473
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD3 abhydrolase domain containing 3
AHDC1 AT hook, DNA binding motif, containing 1
ANKRD11 ankyrin repeat domain 11
ANKRD40 ankyrin repeat domain 40
ARHGAP11A Rho GTPase activating protein 11A
ASB13 ankyrin repeat and SOCS box containing 13
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCCIP BRCA2 and CDKN1A interacting protein
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CAMTA2 calmodulin binding transcription activator 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC109B coiled-coil domain containing 109B
CCDC53 coiled-coil domain containing 53
CELA3B chymotrypsin-like elastase family, member 3B
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLCN6 chloride channel, voltage-sensitive 6
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COG4 component of oligomeric golgi complex 4
COQ3 coenzyme Q3 methyltransferase
CRYAB crystallin, alpha B
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DPH2 DPH2 homolog (S. cerevisiae)
E2F6 E2F transcription factor 6
EHBP1 EH domain binding protein 1
EXD3 exonuclease 3'-5' domain containing 3
FZD4 frizzled class receptor 4
GJB1 gap junction protein, beta 1, 32kDa
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HAGH hydroxyacylglutathione hydrolase
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HPGDS hematopoietic prostaglandin D synthase
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL10 interleukin 10
IL4R interleukin 4 receptor
ITGB7 integrin, beta 7
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KIF21B kinesin family member 21B
KLHL12 kelch-like family member 12
KRT1 keratin 1, type II
KRT32 keratin 32, type I
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LHX6 LIM homeobox 6
LINC00216 long intergenic non-protein coding RNA 216
LMAN2L lectin, mannose-binding 2-like
LUZP4 leucine zipper protein 4
MBNL3 muscleblind-like splicing regulator 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFSD12 major facilitator superfamily domain containing 12
MMP8 matrix metallopeptidase 8
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPV17 MpV17 mitochondrial inner membrane protein
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NCS1 neuronal calcium sensor 1
NKG7 natural killer cell granule protein 7
NOP14 NOP14 nucleolar protein
OARD1 O-acyl-ADP-ribose deacylase 1
PADI2 peptidyl arginine deiminase, type II
PARG poly (ADP-ribose) glycohydrolase
PCTP phosphatidylcholine transfer protein
PEMT phosphatidylethanolamine N-methyltransferase
PFAS phosphoribosylformylglycinamidine synthase
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLVAP plasmalemma vesicle associated protein
PRKCE protein kinase C, epsilon
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RBP1 retinol binding protein 1, cellular
RIPK4 receptor-interacting serine-threonine kinase 4
RWDD3 RWD domain containing 3
SCD5 stearoyl-CoA desaturase 5
SH3BP1 SH3-domain binding protein 1
SIX6 SIX homeobox 6
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SPDL1 spindle apparatus coiled-coil protein 1
SST somatostatin
STRA13 stimulated by retinoic acid 13
TET3 tet methylcytosine dioxygenase 3
TGFB3 transforming growth factor, beta 3
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM127 transmembrane protein 127
TRAPPC12 trafficking protein particle complex 12
TRIM32 tripartite motif containing 32
TRNAU1AP tRNA selenocysteine 1 associated protein 1
WDR11 WD repeat domain 11
WRB tryptophan rich basic protein
WT1-AS WT1 antisense RNA
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZBTB48 zinc finger and BTB domain containing 48
ZNF107 zinc finger protein 107
ZNF443 zinc finger protein 443
ZNF480 zinc finger protein 480
ZNF557 zinc finger protein 557