rofecoxib-205 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the rofecoxib-205 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAM22 ADAM metallopeptidase domain 22
ADARB1 adenosine deaminase, RNA-specific, B1
ADCY1 adenylate cyclase 1 (brain)
AGFG2 ArfGAP with FG repeats 2
AHCYL1 adenosylhomocysteinase-like 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
AQP6 aquaporin 6, kidney specific
ARHGAP24 Rho GTPase activating protein 24
ARMC4 armadillo repeat containing 4
B3GAT3 beta-1,3-glucuronyltransferase 3
BCL2 B-cell CLL/lymphoma 2
BLK BLK proto-oncogene, Src family tyrosine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAMKV CaM kinase-like vesicle-associated
CCDC176 coiled-coil domain containing 176
CCNT2 cyclin T2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COX5B cytochrome c oxidase subunit Vb
CPB1 carboxypeptidase B1 (tissue)
CRMP1 collapsin response mediator protein 1
CTSO cathepsin O
CUL4B cullin 4B
CYB561 cytochrome b561
DGCR8 DGCR8 microprocessor complex subunit
DNAAF2 dynein, axonemal, assembly factor 2
DUSP9 dual specificity phosphatase 9
ELMO2 engulfment and cell motility 2
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EPS8L3 EPS8-like 3
GEMIN7 gem (nuclear organelle) associated protein 7
GHRHR growth hormone releasing hormone receptor
GLB1L galactosidase, beta 1-like
GON4L gon-4-like (C. elegans)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR176 G protein-coupled receptor 176
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSK3A glycogen synthase kinase 3 alpha
GYPC glycophorin C (Gerbich blood group)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHIPL2 HHIP-like 2
HOMER3 homer scaffolding protein 3
HOXD1 homeobox D1
IL1RN interleukin 1 receptor antagonist
ING4 inhibitor of growth family, member 4
KIAA0141 KIAA0141
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KMT2A lysine (K)-specific methyltransferase 2A
LY6G6D lymphocyte antigen 6 complex, locus G6D
LZTS1 leucine zipper, putative tumor suppressor 1
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MARC2 mitochondrial amidoxime reducing component 2
MBNL2 muscleblind-like splicing regulator 2
MIPEP mitochondrial intermediate peptidase
MST1 macrophage stimulating 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NHEJ1 nonhomologous end-joining factor 1
NMT1 N-myristoyltransferase 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUP98 nucleoporin 98kDa
ORC1 origin recognition complex, subunit 1
PARG poly (ADP-ribose) glycohydrolase
PAX8 paired box 8
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTCRA pre T-cell antigen receptor alpha
RALB v-ral simian leukemia viral oncogene homolog B
RIC3 RIC3 acetylcholine receptor chaperone
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A1 S100 calcium binding protein A1
SASH1 SAM and SH3 domain containing 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SFTPC surfactant protein C
SGSM3 small G protein signaling modulator 3
SHPK sedoheptulokinase
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMYD5 SMYD family member 5
SPG20 spastic paraplegia 20 (Troyer syndrome)
SYT12 synaptotagmin XII
TBC1D4 TBC1 domain family, member 4
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TNPO2 transportin 2
TRAM2 translocation associated membrane protein 2
TSC22D2 TSC22 domain family, member 2
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR5B WD repeat domain 5B
WIPF1 WAS/WASL interacting protein family, member 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZMYM2 zinc finger, MYM-type 2
ZNF576 zinc finger protein 576
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ADAM9 ADAM metallopeptidase domain 9
ATF7IP2 activating transcription factor 7 interacting protein 2
AXIN1 axin 1
BBC3 BCL2 binding component 3
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BRS3 bombesin-like receptor 3
C11ORF80 chromosome 11 open reading frame 80
C14ORF79 chromosome 14 open reading frame 79
C19ORF73 chromosome 19 open reading frame 73
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC25 coiled-coil domain containing 25
CCDC28A coiled-coil domain containing 28A
CCDC94 coiled-coil domain containing 94
CCNJL cyclin J-like
CD82 CD82 molecule
CDT1 chromatin licensing and DNA replication factor 1
CES3 carboxylesterase 3
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CNTD2 cyclin N-terminal domain containing 2
CNTN1 contactin 1
COBL cordon-bleu WH2 repeat protein
CORO7 coronin 7
CTNNBIP1 catenin, beta interacting protein 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EPX eosinophil peroxidase
ERCC2 excision repair cross-complementation group 2
FBXL15 F-box and leucine-rich repeat protein 15
FGF16 fibroblast growth factor 16
FGGY FGGY carbohydrate kinase domain containing
FKBP6 FK506 binding protein 6, 36kDa
FRMD1 FERM domain containing 1
FUZ fuzzy planar cell polarity protein
GCKR glucokinase (hexokinase 4) regulator
GLS2 glutaminase 2 (liver, mitochondrial)
GP6 glycoprotein VI (platelet)
GRIP2 glutamate receptor interacting protein 2
GRK1 G protein-coupled receptor kinase 1
HBD hemoglobin, delta
HDAC7 histone deacetylase 7
HHLA1 HERV-H LTR-associating 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL15RA interleukin 15 receptor, alpha
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLHL26 kelch-like family member 26
LHB luteinizing hormone beta polypeptide
LOC100286895 cell division cycle 27 homolog pseudogene
MARC1 mitochondrial amidoxime reducing component 1
MON1B MON1 secretory trafficking family member B
MTERF4 mitochondrial transcription termination factor 4
NKAIN1 Na+/K+ transporting ATPase interacting 1
NKX2-5 NK2 homeobox 5
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NUPL2 nucleoporin like 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCSK7 proprotein convertase subtilisin/kexin type 7
PDZD7 PDZ domain containing 7
PIPOX pipecolic acid oxidase
PLCD1 phospholipase C, delta 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLXNB3 plexin B3
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
RAB3A RAB3A, member RAS oncogene family
REM1 RAS (RAD and GEM)-like GTP-binding 1
RND1 Rho family GTPase 1
RNF141 ring finger protein 141
RNF39 ring finger protein 39
S1PR4 sphingosine-1-phosphate receptor 4
SLC17A4 solute carrier family 17, member 4
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX21 SRY (sex determining region Y)-box 21
STAB2 stabilin 2
SULT4A1 sulfotransferase family 4A, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNPO synaptopodin
TET3 tet methylcytosine dioxygenase 3
TGM5 transglutaminase 5
TMEM242 transmembrane protein 242
TMPRSS5 transmembrane protease, serine 5
TRAC T cell receptor alpha constant
USB1 U6 snRNA biogenesis 1
WDR13 WD repeat domain 13
WNT10B wingless-type MMTV integration site family, member 10B
ZNF248 zinc finger protein 248
ZNF652 zinc finger protein 652
ZNHIT2 zinc finger, HIT-type containing 2
ZXDC ZXD family zinc finger C