riluzole-4689 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the riluzole-4689 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALPPL2 alkaline phosphatase, placental-like 2
AMACR alpha-methylacyl-CoA racemase
ANGEL2 angel homolog 2 (Drosophila)
ANP32A-IT1 ANP32A intronic transcript 1
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
BMP1 bone morphogenetic protein 1
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C2ORF72 chromosome 2 open reading frame 72
CAMK4 calcium/calmodulin-dependent protein kinase IV
CFAP45 cilia and flagella associated protein 45
CFHR4 complement factor H-related 4
CTBP2 C-terminal binding protein 2
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DMTN dematin actin binding protein
DNM3 dynamin 3
EPHB2 EPH receptor B2
ERO1LB ERO1-like beta (S. cerevisiae)
FAM149A family with sequence similarity 149, member A
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FRMD4A FERM domain containing 4A
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GRB10 growth factor receptor-bound protein 10
GRIP2 glutamate receptor interacting protein 2
GRK5 G protein-coupled receptor kinase 5
HIST1H3E histone cluster 1, H3e
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICOSLG inducible T-cell co-stimulator ligand
IL5RA interleukin 5 receptor, alpha
KLF2 Kruppel-like factor 2
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMC2 laminin, gamma 2
LAMP1 lysosomal-associated membrane protein 1
LARP7 La ribonucleoprotein domain family, member 7
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC644450 uncharacterized LOC644450
LRRN3 leucine rich repeat neuronal 3
MAK male germ cell-associated kinase
MCAM melanoma cell adhesion molecule
MEGF8 multiple EGF-like-domains 8
MUC6 mucin 6, oligomeric mucus/gel-forming
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPR2 natriuretic peptide receptor 2
NPY4R neuropeptide Y receptor Y4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PALM paralemmin
PAOX polyamine oxidase (exo-N4-amino)
PARD6B par-6 family cell polarity regulator beta
PCDHB13 protocadherin beta 13
PCSK7 proprotein convertase subtilisin/kexin type 7
PHF20 PHD finger protein 20
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLD2 phospholipase D2
PLEKHS1 pleckstrin homology domain containing, family S member 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRDM2 PR domain containing 2, with ZNF domain
PVR poliovirus receptor
RAB3B RAB3B, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RHAG Rh-associated glycoprotein
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RND1 Rho family GTPase 1
RNF122 ring finger protein 122
SAP30 Sin3A-associated protein, 30kDa
SCAND2P SCAN domain containing 2 pseudogene
SCD5 stearoyl-CoA desaturase 5
SCN10A sodium channel, voltage gated, type X alpha subunit
SCRN3 secernin 3
SERHL2 serine hydrolase-like 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIDT2 SID1 transmembrane family, member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPRY4 sprouty homolog 4 (Drosophila)
SRSF6 serine/arginine-rich splicing factor 6
ST5 suppression of tumorigenicity 5
TAOK1 TAO kinase 1
TEP1 telomerase-associated protein 1
TESC tescalcin
TFEB transcription factor EB
TOP3B topoisomerase (DNA) III beta
TRIM15 tripartite motif containing 15
TROVE2 TROVE domain family, member 2
TUBA3C tubulin, alpha 3c
TYRP1 tyrosinase-related protein 1
UHRF1BP1L UHRF1 binding protein 1-like
WIPI2 WD repeat domain, phosphoinositide interacting 2
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YTHDC2 YTH domain containing 2
ZFP37 ZFP37 zinc finger protein
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACSL4 acyl-CoA synthetase long-chain family member 4
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASAP1-IT1 ASAP1 intronic transcript 1
ATAD5 ATPase family, AAA domain containing 5
BGLAP bone gamma-carboxyglutamate (gla) protein
C7ORF69 chromosome 7 open reading frame 69
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCDC69 coiled-coil domain containing 69
CD2AP CD2-associated protein
CD3D CD3d molecule, delta (CD3-TCR complex)
CD79A CD79a molecule, immunoglobulin-associated alpha
CLIC2 chloride intracellular channel 2
CORT cortistatin
CRABP1 cellular retinoic acid binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRYGC crystallin, gamma C
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNALI1 dynein, axonemal, light intermediate chain 1
DOC2A double C2-like domains, alpha
DRD1 dopamine receptor D1
DTX4 deltex 4, E3 ubiquitin ligase
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FBRS fibrosin
FLJ21369 uncharacterized protein FLJ21369
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GLRA1 glycine receptor, alpha 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AL histone cluster 1, H2al
HLA-J major histocompatibility complex, class I, J (pseudogene)
INF2 inverted formin, FH2 and WH2 domain containing
JADE3 jade family PHD finger 3
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIAA0894 KIAA0894 protein
LHX6 LIM homeobox 6
LIME1 Lck interacting transmembrane adaptor 1
LIN7A lin-7 homolog A (C. elegans)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC257152 uncharacterized LOC257152
LRRC20 leucine rich repeat containing 20
LRRC37A2 leucine rich repeat containing 37, member A2
MAPK12 mitogen-activated protein kinase 12
MAST3 microtubule associated serine/threonine kinase 3
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MRPL41 mitochondrial ribosomal protein L41
MTA2 metastasis associated 1 family, member 2
MUC3B mucin 3B, cell surface associated
MVP major vault protein
MYLK myosin light chain kinase
NECAB3 N-terminal EF-hand calcium binding protein 3
NEUROD1 neuronal differentiation 1
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLA2G15 phospholipase A2, group XV
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRB3 proline-rich protein BstNI subfamily 3
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRSS53 protease, serine, 53
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB33B RAB33B, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF126P1 ring finger protein 126 pseudogene 1
SAMD9 sterile alpha motif domain containing 9
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SNTA1 syntrophin, alpha 1
SPRR2B small proline-rich protein 2B
SPRY2 sprouty homolog 2 (Drosophila)
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAG3 stromal antigen 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TMC5 transmembrane channel-like 5
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM212 transmembrane protein 212
TUBA3D tubulin, alpha 3d
TUBB2B tubulin, beta 2B class IIb
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
VASH1 vasohibin 1
VASH2 vasohibin 2
VAX2 ventral anterior homeobox 2
VIM vimentin
ZNF350 zinc finger protein 350
ZNF37BP zinc finger protein 37B, pseudogene
ZNF446 zinc finger protein 446
ZNF665 zinc finger protein 665