riluzole-2295 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the riluzole-2295 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADAM12 ADAM metallopeptidase domain 12
ADAM22 ADAM metallopeptidase domain 22
ADORA1 adenosine A1 receptor
AKT3 v-akt murine thymoma viral oncogene homolog 3
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APC adenomatous polyposis coli
ARC activity-regulated cytoskeleton-associated protein
ARHGAP33 Rho GTPase activating protein 33
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
C1QB complement component 1, q subcomponent, B chain
CA9 carbonic anhydrase IX
CALB2 calbindin 2
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CD3D CD3d molecule, delta (CD3-TCR complex)
CD8A CD8a molecule
CDHR2 cadherin-related family member 2
CHN2 chimerin 2
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
COL3A1 collagen, type III, alpha 1
COL7A1 collagen, type VII, alpha 1
CPQ carboxypeptidase Q
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DFNB31 deafness, autosomal recessive 31
DGAT1 diacylglycerol O-acyltransferase 1
ELL elongation factor RNA polymerase II
EPN1 epsin 1
F5 coagulation factor V (proaccelerin, labile factor)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GLS glutaminase
GPR153 G protein-coupled receptor 153
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HEXA-AS1 HEXA antisense RNA 1
HHAT hedgehog acyltransferase
HHLA1 HERV-H LTR-associating 1
HIST1H3I histone cluster 1, H3i
HNMT histamine N-methyltransferase
IGKC immunoglobulin kappa constant
INSL4 insulin-like 4 (placenta)
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCTD17 potassium channel tetramerization domain containing 17
KLHL20 kelch-like family member 20
KREMEN2 kringle containing transmembrane protein 2
KRT38 keratin 38, type I
KRT83 keratin 83, type II
LAMA4 laminin, alpha 4
LGALS8 lectin, galactoside-binding, soluble, 8
LOXL3 lysyl oxidase-like 3
LTBP2 latent transforming growth factor beta binding protein 2
LUZP4 leucine zipper protein 4
MEG3 maternally expressed 3 (non-protein coding)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXD1 MAX dimerization protein 1
NDRG2 NDRG family member 2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEK1 NIMA-related kinase 1
NOX1 NADPH oxidase 1
NPR3 natriuretic peptide receptor 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
OMD osteomodulin
OPRL1 opiate receptor-like 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4C phosphodiesterase 4C, cAMP-specific
PDE9A phosphodiesterase 9A
PEG10 paternally expressed 10
PILRA paired immunoglobin-like type 2 receptor alpha
PLXNA2 plexin A2
PRDM1 PR domain containing 1, with ZNF domain
PRKCQ protein kinase C, theta
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PVT1 Pvt1 oncogene (non-protein coding)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPS3A ribosomal protein S3A
RUNX1 runt-related transcription factor 1
S100A9 S100 calcium binding protein A9
SBNO2 strawberry notch homolog 2 (Drosophila)
SECTM1 secreted and transmembrane 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPN sialophorin
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTB spectrin, beta, erythrocytic
SPTBN5 spectrin, beta, non-erythrocytic 5
SSX3 synovial sarcoma, X breakpoint 3
STMN3 stathmin-like 3
STXBP6 syntaxin binding protein 6 (amisyn)
SYT11 synaptotagmin XI
SYT13 synaptotagmin XIII
TGFA transforming growth factor, alpha
TIMP3 TIMP metallopeptidase inhibitor 3
TLN1 talin 1
TMEM212 transmembrane protein 212
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZC3H7B zinc finger CCCH-type containing 7B

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACSL4 acyl-CoA synthetase long-chain family member 4
ADCY6 adenylate cyclase 6
ADGRG2 adhesion G protein-coupled receptor G2
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AFAP1 actin filament associated protein 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASAP1-IT1 ASAP1 intronic transcript 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAG4 BCL2-associated athanogene 4
BAHD1 bromo adjacent homology domain containing 1
BEX4 brain expressed, X-linked 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C11ORF30 chromosome 11 open reading frame 30
C19ORF73 chromosome 19 open reading frame 73
CA5BP1 carbonic anhydrase VB pseudogene 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD83 CD83 molecule
CENPO centromere protein O
CLCF1 cardiotrophin-like cytokine factor 1
CLCN5 chloride channel, voltage-sensitive 5
CLDND1 claudin domain containing 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
EGFL7 EGF-like-domain, multiple 7
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERO1L ERO1-like (S. cerevisiae)
F8 coagulation factor VIII, procoagulant component
FAM169A family with sequence similarity 169, member A
FERMT1 fermitin family member 1
FGF23 fibroblast growth factor 23
FLT4 fms-related tyrosine kinase 4
FOXI1 forkhead box I1
FRS2 fibroblast growth factor receptor substrate 2
GID4 GID complex subunit 4
GMEB1 glucocorticoid modulatory element binding protein 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPX2 glutathione peroxidase 2
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HP1BP3 heterochromatin protein 1, binding protein 3
IFT140 intraflagellar transport 140
IRAK4 interleukin-1 receptor-associated kinase 4
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
LIN7B lin-7 homolog B (C. elegans)
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAGEB2 melanoma antigen family B2
MCC mutated in colorectal cancers
MCOLN3 mucolipin 3
MVD mevalonate (diphospho) decarboxylase
MVP major vault protein
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
OLFML2A olfactomedin-like 2A
OSMR oncostatin M receptor
PCDHA6 protocadherin alpha 6
PCDHB13 protocadherin beta 13
PCDHB3 protocadherin beta 3
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
POLL polymerase (DNA directed), lambda
RLN1 relaxin 1
SCAI suppressor of cancer cell invasion
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGPP1 sphingosine-1-phosphate phosphatase 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOAT1 sterol O-acyltransferase 1
SP1 Sp1 transcription factor
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TFF2 trefoil factor 2
THBS3 thrombospondin 3
TICAM1 toll-like receptor adaptor molecule 1
TMEM2 transmembrane protein 2
TMEM57 transmembrane protein 57
TMUB2 transmembrane and ubiquitin-like domain containing 2
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAPPC6A trafficking protein particle complex 6A
TSPAN1 tetraspanin 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
USP20 ubiquitin specific peptidase 20
WDR4 WD repeat domain 4
ZBTB6 zinc finger and BTB domain containing 6
ZNF227 zinc finger protein 227
ZNF365 zinc finger protein 365
ZNF571 zinc finger protein 571
ZNF573 zinc finger protein 573
ZNF668 zinc finger protein 668
ZNF862 zinc finger protein 862