rifabutin-4349 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the rifabutin-4349 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADAM19 ADAM metallopeptidase domain 19
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
ANG angiogenin, ribonuclease, RNase A family, 5
ARMCX2 armadillo repeat containing, X-linked 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATXN7L1 ataxin 7-like 1
BTN2A2 butyrophilin, subfamily 2, member A2
CCDC88A coiled-coil domain containing 88A
CEP112 centrosomal protein 112kDa
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLGN calmegin
CSRP2 cysteine and glycine-rich protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL4 dihydropyrimidinase-like 4
EFNB3 ephrin-B3
ELOVL4 ELOVL fatty acid elongase 4
EMP1 epithelial membrane protein 1
EPHB2 EPH receptor B2
FAM105A family with sequence similarity 105, member A
FAM184A family with sequence similarity 184, member A
FAM49A family with sequence similarity 49, member A
FBXL7 F-box and leucine-rich repeat protein 7
FRMD1 FERM domain containing 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GABARAPL1 GABA(A) receptor-associated protein like 1
GK glycerol kinase
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRK5 G protein-coupled receptor kinase 5
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA1 homeobox A1
HPCAL4 hippocalcin like 4
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
JAG1 jagged 1
KIF21B kinesin family member 21B
KIF5C kinesin family member 5C
LINC00341 long intergenic non-protein coding RNA 341
LRRC49 leucine rich repeat containing 49
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
METTL7A methyltransferase like 7A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MTSS1 metastasis suppressor 1
MUC3B mucin 3B, cell surface associated
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
NAP1L3 nucleosome assembly protein 1-like 3
NME5 NME/NM23 family member 5
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDGFC platelet derived growth factor C
PGAM2 phosphoglycerate mutase 2 (muscle)
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRPH peripherin
RAB29 RAB29, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RAI2 retinoic acid induced 2
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
REEP1 receptor accessory protein 1
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RNASE4 ribonuclease, RNase A family, 4
RUNDC3B RUN domain containing 3B
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFXN3 sideroflexin 3
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STON1 stonin 1
STYK1 serine/threonine/tyrosine kinase 1
TBXA2R thromboxane A2 receptor
TFEB transcription factor EB
TNIK TRAF2 and NCK interacting kinase
TNS1 tensin 1
TRIM2 tripartite motif containing 2
TRIM36 tripartite motif containing 36
VWA5A von Willebrand factor A domain containing 5A
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ACTL8 actin-like 8
ADRA2C adrenoceptor alpha 2C
AES amino-terminal enhancer of split
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
AXIN1 axin 1
B9D2 B9 protein domain 2
C14ORF79 chromosome 14 open reading frame 79
C17ORF70 chromosome 17 open reading frame 70
CAPN15 calpain 15
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC94 coiled-coil domain containing 94
CCND1 cyclin D1
CDT1 chromatin licensing and DNA replication factor 1
CISH cytokine inducible SH2-containing protein
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CTSD cathepsin D
CXCL12 chemokine (C-X-C motif) ligand 12
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DUSP3 dual specificity phosphatase 3
EFNA1 ephrin-A1
ELMO3 engulfment and cell motility 3
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EVPL envoplakin
FAAH fatty acid amide hydrolase
GALK1 galactokinase 1
GATA4 GATA binding protein 4
GMEB1 glucocorticoid modulatory element binding protein 1
GRWD1 glutamate-rich WD repeat containing 1
GTF2I general transcription factor IIi
IGFBP4 insulin-like growth factor binding protein 4
KCTD15 potassium channel tetramerization domain containing 15
KEAP1 kelch-like ECH-associated protein 1
KIAA0319L KIAA0319-like
LMNB2 lamin B2
LPAR2 lysophosphatidic acid receptor 2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC41 leucine rich repeat containing 41
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LY6D lymphocyte antigen 6 complex, locus D
LY6G5C lymphocyte antigen 6 complex, locus G5C
MARC1 mitochondrial amidoxime reducing component 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCRS1 microspherule protein 1
MEPCE methylphosphate capping enzyme
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MPDU1 mannose-P-dolichol utilization defect 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTG1 mitochondrial ribosome-associated GTPase 1
NABP2 nucleic acid binding protein 2
NIPAL2 NIPA-like domain containing 2
NME6 NME/NM23 nucleoside diphosphate kinase 6
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PIEZO1 piezo-type mechanosensitive ion channel component 1
PISD phosphatidylserine decarboxylase
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLL polymerase (DNA directed), lambda
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PP14571 uncharacterized LOC100130449
PPAN peter pan homolog (Drosophila)
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRR4 proline rich 4 (lacrimal)
PSD4 pleckstrin and Sec7 domain containing 4
PTGES2 prostaglandin E synthase 2
RAB3D RAB3D, member RAS oncogene family
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF208 ring finger protein 208
RPAP1 RNA polymerase II associated protein 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SKI SKI proto-oncogene
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLMO1 slowmo homolog 1 (Drosophila)
SMG5 SMG5 nonsense mediated mRNA decay factor
SMG9 SMG9 nonsense mediated mRNA decay factor
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNHG3 small nucleolar RNA host gene 3
STRN4 striatin, calmodulin binding protein 4
TARBP2 TAR (HIV-1) RNA binding protein 2
THBS3 thrombospondin 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM25 tripartite motif containing 25
UBTF upstream binding transcription factor, RNA polymerase I
UBXN8 UBX domain protein 8
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBTB3 zinc finger and BTB domain containing 3
ZNF286A zinc finger protein 286A
ZNF692 zinc finger protein 692
ZNF747 zinc finger protein 747
ZNF787 zinc finger protein 787