rheumatoid arthritis Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. (Human Disease Ontology, DOID_7148)
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Genes

144 genes associated with the disease rheumatoid arthritis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AR androgen receptor
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
BLK BLK proto-oncogene, Src family tyrosine kinase
C5 complement component 5
C6ORF10 chromosome 6 open reading frame 10
C6ORF15 chromosome 6 open reading frame 15
CARD8 caspase recruitment domain family, member 8
CCBE1 collagen and calcium binding EGF domains 1
CCL21 chemokine (C-C motif) ligand 21
CCL26 chemokine (C-C motif) ligand 26
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD244 CD244 molecule, natural killer cell receptor 2B4
CD40 CD40 molecule, TNF receptor superfamily member 5
CDK6 cyclin-dependent kinase 6
CLEC16A C-type lectin domain family 16, member A
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DEK DEK proto-oncogene
DLG5 discs, large homolog 5 (Drosophila)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EXOC4 exocyst complex component 4
EXOC5 exocyst complex component 5
FAM167A family with sequence similarity 167, member A
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
GC group-specific component (vitamin D binding protein)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GSTM1 glutathione S-transferase mu 1
HAVCR1 hepatitis A virus cellular receptor 1
HAVCR2 hepatitis A virus cellular receptor 2
HBA1 hemoglobin, alpha 1
HFE hemochromatosis
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB2 major histocompatibility complex, class II, DR beta 2 (pseudogene)
HLA-E major histocompatibility complex, class I, E
IFNG interferon, gamma
IL10 interleukin 10
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL26 interleukin 26
IL3 interleukin 3
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
LECT1 leukocyte cell derived chemotaxin 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LY6G6C lymphocyte antigen 6 complex, locus G6C
MBL2 mannose-binding lectin (protein C) 2, soluble
MEFV Mediterranean fever
MICA MHC class I polypeptide-related sequence A
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSH5 mutS homolog 5
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1A melatonin receptor 1A
MTNR1B melatonin receptor 1B
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH4 notch 4
NRM nurim (nuclear envelope membrane protein)
OLIG3 oligodendrocyte transcription factor 3
PADI4 peptidyl arginine deiminase, type IV
PARP1 poly (ADP-ribose) polymerase 1
PDCD1 programmed cell death 1
PGR progesterone receptor
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PPT2 palmitoyl-protein thioesterase 2
PRKCQ protein kinase C, theta
PRRC2A proline-rich coiled-coil 2A
PRRT1 proline-rich transmembrane protein 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RFC1 replication factor C (activator 1) 1, 145kDa
SAA1 serum amyloid A1
SALL3 spalt-like transcription factor 3
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2D2A SH2 domain containing 2A
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SPP1 secreted phosphoprotein 1
STAT4 signal transducer and activator of transcription 4
SUMO4 small ubiquitin-like modifier 4
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TFR2 transferrin receptor 2
TGFB1 transforming growth factor, beta 1
TIMELESS timeless circadian clock
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRAF1 TNF receptor-associated factor 1
TRAF5 TNF receptor-associated factor 5
TRB T cell receptor beta locus
TYMS thymidylate synthetase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A