rheumatoid arthritis Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. (Human Disease Ontology, DOID_7148)
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Genes

296 genes associated with the disease rheumatoid arthritis in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.70409
NOTCH4 notch 4 2.32599
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.14299
PRRC2A proline-rich coiled-coil 2A 2.09583
CFB complement factor B 2.074
BRD2 bromodomain containing 2 1.99244
HLA-DOB major histocompatibility complex, class II, DO beta 1.95203
TNXB tenascin XB 1.94201
LY6G6F lymphocyte antigen 6 complex, locus G6F 1.78282
ABHD16A abhydrolase domain containing 16A 1.78282
HLA-C major histocompatibility complex, class I, C 1.74367
HSPA1L heat shock 70kDa protein 1-like 1.73341
PRRT1 proline-rich transmembrane protein 1 1.723
ATF6B activating transcription factor 6 beta 1.61356
SLC44A4 solute carrier family 44, member 4 1.61356
TRIM26 tripartite motif containing 26 1.54448
PBX2 pre-B-cell leukemia homeobox 2 1.50071
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 1.39702
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 1.34736
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.27521
STK19 serine/threonine kinase 19 1.258
ARID5B AT rich interactive domain 5B (MRF1-like) 1.25426
MICA MHC class I polypeptide-related sequence A 1.24299
AIF1 allograft inflammatory factor 1 1.17894
TRIM31 tripartite motif containing 31 1.12703
ATAT1 alpha tubulin acetyltransferase 1 1.11998
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 1.09588
TRIM40 tripartite motif containing 40 1.07383
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 1.06123
C6ORF47 chromosome 6 open reading frame 47 1.05198
PSORS1C1 psoriasis susceptibility 1 candidate 1 1.05198
NEU1 sialidase 1 (lysosomal sialidase) 1.0394
ZNF99 zinc finger protein 99 1.02486
AFF3 AF4/FMR2 family, member 3 1.02486
ZFP57 ZFP57 zinc finger protein 1.02486
POU5F1 POU class 5 homeobox 1 1.00628
PLD4 phospholipase D family, member 4 1.00628
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.995303
MICB MHC class I polypeptide-related sequence B 0.995303
IP6K3 inositol hexakisphosphate kinase 3 0.965481
HLA-E major histocompatibility complex, class I, E 0.965481
MUC21 mucin 21, cell surface associated 0.965481
TRIM15 tripartite motif containing 15 0.932337
HLA-A major histocompatibility complex, class I, A 0.923046
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 0.894262
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 0.894262
ANXA3 annexin A3 0.894262
PUS10 pseudouridylate synthase 10 0.872896
LY6G5C lymphocyte antigen 6 complex, locus G5C 0.85991
DPCR1 diffuse panbronchiolitis critical region 1 0.842276
IL2RA interleukin 2 receptor, alpha 0.817078
RPP21 ribonuclease P/MRP 21kDa subunit 0.817078
ANKRD55 ankyrin repeat domain 55 0.817078
CCR6 chemokine (C-C motif) receptor 6 0.790827
TNPO3 transportin 3 0.7623
ZNRD1 zinc ribbon domain containing 1 0.7623
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.724323
HLA-DOA major histocompatibility complex, class II, DO alpha 0.724323
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 0.69843
C6ORF15 chromosome 6 open reading frame 15 0.69843
BAG6 BCL2-associated athanogene 6 0.682635
HLA-B major histocompatibility complex, class I, B 0.682635
HLA-G major histocompatibility complex, class I, G 0.682635
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.682635
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 0.670996
FAM205A family with sequence similarity 205, member A 0.670996
BCL2L15 BCL2-like 15 0.661797
SPRED2 sprouty-related, EVH1 domain containing 2 0.661797
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.65413
PDE2A phosphodiesterase 2A, cGMP-stimulated 0.65413
CCSER2 coiled-coil serine-rich protein 2 0.647573
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.63207
MLN motilin 0.63207
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.602429
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 0.602429
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.58494
CD40 CD40 molecule, TNF receptor superfamily member 5 0.58494
AIRE autoimmune regulator 0.572184
RTKN2 rhotekin 2 0.561725
GPANK1 G patch domain and ankyrin repeats 1 0.552621
IER3 immediate early response 3 0.52461
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 0.52461
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.52461
B3GNT1 0.52461
CD83 CD83 molecule 0.486425
PHF19 PHD finger protein 19 0.486425
PADI4 peptidyl arginine deiminase, type IV 0.486425
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.486425
SEC24B SEC24 family member B 0.486425
KIFC1 kinesin family member C1 0.486425
LRRC18 leucine rich repeat containing 18 0.486425
OCA2 oculocutaneous albinism II 0.486425
WDFY4 WDFY family member 4 0.486425
CCL27 chemokine (C-C motif) ligand 27 0.486425
TNF tumor necrosis factor 0.486425
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 0.486425
CCL21 chemokine (C-C motif) ligand 21 0.464771
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.464771
C5ORF30 chromosome 5 open reading frame 30 0.449873
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.449873
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.449873
NFIA nuclear factor I/A 0.438544
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 0.438544
C5 complement component 5 0.438544
CNTFR ciliary neurotrophic factor receptor 0.438544
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.438544
FAM107A family with sequence similarity 107, member A 0.438544
CDSN corneodesmosin 0.4215
DOK6 docking protein 6 0.4215
ZSCAN26 zinc finger and SCAN domain containing 26 0.414708
FAM65B family with sequence similarity 65, member B 0.414708
MCTP1 multiple C2 domains, transmembrane 1 0.414708
NKAPL NFKB activating protein-like 0.414708
KIF5A kinesin family member 5A 0.408752
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.408752
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.403461
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.403461
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 0.403461
RIT2 Ras-like without CAAX 2 0.403461
MMEL1 membrane metallo-endopeptidase-like 1 0.403461
RAB14 RAB14, member RAS oncogene family 0.403461
BATF basic leucine zipper transcription factor, ATF-like 0.403461
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.403461
NRXN1 neurexin 1 0.368757
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.368757
TRAF1 TNF receptor-associated factor 1 0.368757
TRPS1 trichorhinophalangeal syndrome I 0.368757
JMJD1C jumonji domain containing 1C 0.368757
COL11A2 collagen, type XI, alpha 2 0.368757
APOM apolipoprotein M 0.368757
GNL1 guanine nucleotide binding protein-like 1 0.368757
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.368757
CLSTN2 calsyntenin 2 0.368757
CCNG2 cyclin G2 0.368757
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.368757
OR2H1 olfactory receptor, family 2, subfamily H, member 1 0.368757
MAS1L MAS1 proto-oncogene like, G protein-coupled receptor 0.345945
ZNF175 zinc finger protein 175 0.345945
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.345945
REEP3 receptor accessory protein 3 0.345945
CPXM1 carboxypeptidase X (M14 family), member 1 0.345945
LTA lymphotoxin alpha 0.345945
CTIF CBP80/20-dependent translation initiation factor 0.345945
PGBD1 piggyBac transposable element derived 1 0.345945
LOC401324 uncharacterized LOC401324 0.345945
PRKCH protein kinase C, eta 0.327313
OLIG3 oligodendrocyte transcription factor 3 0.327313
RPS18 ribosomal protein S18 0.327313
ASB15 ankyrin repeat and SOCS box containing 15 0.327313
PDS5A PDS5 cohesin associated factor A 0.327313
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.327313
GDAP1 ganglioside induced differentiation associated protein 1 0.327313
PHACTR3 phosphatase and actin regulator 3 0.327313
STXBP6 syntaxin binding protein 6 (amisyn) 0.311576
PAPOLA poly(A) polymerase alpha 0.311576
GRHL2 grainyhead-like 2 (Drosophila) 0.311576
RNASET2 ribonuclease T2 0.311576
ZSCAN9 zinc finger and SCAN domain containing 9 0.297866
N4BP1 NEDD4 binding protein 1 0.297866
OTUD7A OTU deubiquitinase 7A 0.297866
BCOR BCL6 corepressor 0.285417
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.285417
FAM169B family with sequence similarity 169, member B 0.285417
FADS1 fatty acid desaturase 1 0.274608
FADS2 fatty acid desaturase 2 0.274608
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.274608
ISG20 interferon stimulated exonuclease gene 20kDa 0.274608
PAX5 paired box 5 0.274608
PCDH15 protocadherin-related 15 0.274608
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.264872
ZPBP2 zona pellucida binding protein 2 0.264872
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.264872
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 0.264872
NTN1 netrin 1 0.264872
PCM1 pericentriolar material 1 0.256228
IL11RA interleukin 11 receptor, alpha 0.256228
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.256228
VTCN1 V-set domain containing T cell activation inhibitor 1 0.256228
BICD1 bicaudal D homolog 1 (Drosophila) 0.256228
DDHD1 DDHD domain containing 1 0.256228
ZNF165 zinc finger protein 165 0.256228
CEP128 centrosomal protein 128kDa 0.256228
PRICKLE1 prickle homolog 1 (Drosophila) 0.256228
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.256228
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.256228
IL6R interleukin 6 receptor 0.256228
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene 0.256228
RBM38 RNA binding motif protein 38 0.256228
TRIM27 tripartite motif containing 27 0.197766
IL2RB interleukin 2 receptor, beta 0.197766
NRG3 neuregulin 3 0.197766
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.197766
GCH1 GTP cyclohydrolase 1 0.197766
PARK2 parkin RBR E3 ubiquitin protein ligase 0.197766
LOC399716 uncharacterized LOC399716 0.197766
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 0.197766
CD247 CD247 molecule 0.197766
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.197766
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.197766
HRH2 histamine receptor H2 0.197766
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.197766
LONRF2 LON peptidase N-terminal domain and ring finger 2 0.197766
STAT4 signal transducer and activator of transcription 4 0.197766
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.197766
FGFR1OP FGFR1 oncogene partner 0.197766
TBX5 T-box 5 0.197766
RPLP1 ribosomal protein, large, P1 0.197766
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.197766
DAXX death-domain associated protein 0.15771
TAPBP TAP binding protein (tapasin) 0.15771
MAP2K6 mitogen-activated protein kinase kinase 6 0.15771
DCLRE1C DNA cross-link repair 1C 0.15771
OR2B6 olfactory receptor, family 2, subfamily B, member 6 0.15771
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.15771
LEMD2 LEM domain containing 2 0.15771
TMPO thymopoietin 0.15771
CNTNAP4 contactin associated protein-like 4 0.15771
TMEM121 transmembrane protein 121 0.15771
EGR2 early growth response 2 0.15771
KLF7 Kruppel-like factor 7 (ubiquitous) 0.15771
UNC5C unc-5 homolog C (C. elegans) 0.126165
OR5V1 olfactory receptor, family 5, subfamily V, member 1 0.126165
DNAI1 dynein, axonemal, intermediate chain 1 0.126165
UBASH3A ubiquitin associated and SH3 domain containing A 0.126165
OLFML3 olfactomedin-like 3 0.126165
CDK6 cyclin-dependent kinase 6 0.126165
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 0.126165
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.126165
PRKCB protein kinase C, beta 0.126165
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.126165
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 0.126165
SIGLEC6 sialic acid binding Ig-like lectin 6 0.100789
KIAA1109 KIAA1109 0.100789
BLK BLK proto-oncogene, Src family tyrosine kinase 0.100789
ZBTB38 zinc finger and BTB domain containing 38 0.100789
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.100789
BTN3A3 butyrophilin, subfamily 3, member A3 0.100789
ENHO energy homeostasis associated 0.100789
MRPS31 mitochondrial ribosomal protein S31 0.100789
TAGAP T-cell activation RhoGTPase activating protein 0.100789
ALPL alkaline phosphatase, liver/bone/kidney 0.080593
GSN gelsolin 0.080593
GPX3 glutathione peroxidase 3 0.080593
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.080593
ADGRA1 adhesion G protein-coupled receptor A1 0.080593
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 0.080593
HIATL1 hippocampus abundant transcript-like 1 0.080593
GALC galactosylceramidase 0.080593
TRHDE thyrotropin-releasing hormone degrading enzyme 0.080593
FOXO1 forkhead box O1 0.080593
NCALD neurocalcin delta 0.080593
DSCAM Down syndrome cell adhesion molecule 0.080593
PAPOLG poly(A) polymerase gamma 0.080593
ZCCHC6 zinc finger, CCHC domain containing 6 0.080593
ZMYM4 zinc finger, MYM-type 4 0.080593
SALL3 spalt-like transcription factor 3 0.080593
HMG20A high mobility group 20A 0.080593
SH2B3 SH2B adaptor protein 3 0.080593
EMILIN2 elastin microfibril interfacer 2 0.064973
SFTA2 surfactant associated 2 0.064973
HSPA14 heat shock 70kDa protein 14 0.064973
ATE1 arginyltransferase 1 0.064973
TNR tenascin R 0.064973
ZDBF2 zinc finger, DBF-type containing 2 0.064973
PTPRJ protein tyrosine phosphatase, receptor type, J 0.064973
NRM nurim (nuclear envelope membrane protein) 0.064973
PARD3B par-3 family cell polarity regulator beta 0.064973
BTN2A1 butyrophilin, subfamily 2, member A1 0.052255
HLA-DMA major histocompatibility complex, class II, DM alpha 0.052255
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.052255
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 0.052255
HSP90AA6P heat shock protein 90kDa alpha (cytosolic), class A member 6, pseudogene 0.052255
EIF4E3 eukaryotic translation initiation factor 4E family member 3 0.052255
CDNF cerebral dopamine neurotrophic factor 0.052255
ERBB4 erb-b2 receptor tyrosine kinase 4 0.052255
AHR aryl hydrocarbon receptor 0.052255
CELF2 CUGBP, Elav-like family member 2 0.043246
SHKBP1 SH3KBP1 binding protein 1 0.043246
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.043246
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.043246
PTMAP5 prothymosin, alpha pseudogene 5 0.043246
ABT1 activator of basal transcription 1 0.043246
C9ORF152 chromosome 9 open reading frame 152 0.043246
PRSS16 protease, serine, 16 (thymus) 0.035343
YTHDC2 YTH domain containing 2 0.035343
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.035343
PADI2 peptidyl arginine deiminase, type II 0.035343
TMEM135 transmembrane protein 135 0.035343
PHTF1 putative homeodomain transcription factor 1 0.035343
NPAT nuclear protein, ataxia-telangiectasia locus 0.035343
FAM135B family with sequence similarity 135, member B 0.035343
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.035343
CALCOCO1 calcium binding and coiled-coil domain 1 0.035343
CD2 CD2 molecule 0.035343
RSBN1 round spermatid basic protein 1 0.035343
DEPDC5 DEP domain containing 5 0.035343