rheumatoid arthritis disease specific synovial tissue Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Chronic inflammatory disease in which there is destruction of joints. Considered by some to be an autoimmune disorder in which immune complexes are formed in joints and excite an inflammatory response (complex mediated hypersensitivity). Cell-mediated (type IV) hypersensitivity also occurs and macrophages accumulate. This in turn leads to the destruction of the synovial lining. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003702)
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Genes

303 proteins co-occuring with the tissue rheumatoid arthritis disease specific synovial tissue in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
MMP3 matrix metallopeptidase 3 1.69948
MMP1 matrix metallopeptidase 1 1.64406
IL1B interleukin 1, beta 1.60465
TNF tumor necrosis factor 1.36131
PMFBP1 polyamine modulated factor 1 binding protein 1 1.27919
MMP13 matrix metallopeptidase 13 1.15495
CCL2 chemokine (C-C motif) ligand 2 1.09253
TLR2 toll-like receptor 2 1.06956
TLR4 toll-like receptor 4 1.02732
MIR346 microRNA 346 1.02644
TLR3 toll-like receptor 3 1.0225
PSORS1C1 psoriasis susceptibility 1 candidate 1 1.00807
IL17A interleukin 17A 1.00065
MMP9 matrix metallopeptidase 9 0.975449
JUN jun proto-oncogene 0.928478
IL6 interleukin 6 0.926336
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.91308
DYNLRB1 dynein, light chain, roadblock-type 1 0.906256
IL18 interleukin 18 0.904978
IL32 interleukin 32 0.90285
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.887133
CCR6 chemokine (C-C motif) receptor 6 0.88671
SSC5D scavenger receptor cysteine rich family, 5 domains 0.884167
TADA1 transcriptional adaptor 1 0.871061
WDFY3 WD repeat and FYVE domain containing 3 0.859258
IL17RC interleukin 17 receptor C 0.829453
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.806465
MMP2 matrix metallopeptidase 2 0.805213
IL22RA1 interleukin 22 receptor, alpha 1 0.800208
AP3D1 adaptor-related protein complex 3, delta 1 subunit 0.796041
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.794792
CD4 CD4 molecule 0.793959
E2F2 E2F transcription factor 2 0.792293
TIMP1 TIMP metallopeptidase inhibitor 1 0.785635
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.780648
SUMO1 small ubiquitin-like modifier 1 0.768612
CXCL16 chemokine (C-X-C motif) ligand 16 0.75495
SENP1 SUMO1/sentrin specific peptidase 1 0.73803
CXCL10 chemokine (C-X-C motif) ligand 10 0.73803
ANXA5 annexin A5 0.727741
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.723631
CD68 CD68 molecule 0.719524
CXCR6 chemokine (C-X-C motif) receptor 6 0.704764
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.697808
PHOSPHO2 phosphatase, orphan 2 0.694946
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.688817
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.686776
TP53 tumor protein p53 0.679433
PLA2G1B phospholipase A2, group IB (pancreas) 0.674543
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.671692
KIAA1524 KIAA1524 0.670064
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.66925
PLAA phospholipase A2-activating protein 0.666809
IL1RN interleukin 1 receptor antagonist 0.662742
IRAK4 interleukin-1 receptor-associated kinase 4 0.644074
BTK Bruton agammaglobulinemia tyrosine kinase 0.639214
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.633549
VCAM1 vascular cell adhesion molecule 1 0.631931
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.627081
FBXO3 F-box protein 3 0.625869
CXCR3 chemokine (C-X-C motif) receptor 3 0.625061
BAIAP2L1 BAI1-associated protein 2-like 1 0.624658
CCL3 chemokine (C-C motif) ligand 3 0.622639
CYR61 cysteine-rich, angiogenic inducer, 61 0.614571
PDCD5 programmed cell death 5 0.613361
WISP3 WNT1 inducible signaling pathway protein 3 0.608124
MGARP mitochondria-localized glutamic acid-rich protein 0.605306
TRIM2 tripartite motif containing 2 0.602892
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.590036
IL2 interleukin 2 0.589234
MTX3 metaxin 3 0.575216
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.565631
IL2RA interleukin 2 receptor, alpha 0.563238
IFNL1 interferon, lambda 1 0.56284
CD44 CD44 molecule (Indian blood group) 0.560847
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.559254
JAK2 Janus kinase 2 0.557661
ICAM1 intercellular adhesion molecule 1 0.55607
CXCL8 chemokine (C-X-C motif) ligand 8 0.551695
MAPK8 mitogen-activated protein kinase 8 0.550503
MAPK9 mitogen-activated protein kinase 9 0.548914
CALCR calcitonin receptor 0.546929
ACPP acid phosphatase, prostate 0.542566
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.538604
CRP C-reactive protein, pentraxin-related 0.527928
BAX BCL2-associated X protein 0.516891
IL23A interleukin 23, alpha subunit p19 0.51453
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 0.512564
CD40 CD40 molecule, TNF receptor superfamily member 5 0.501182
CAPG capping protein (actin filament), gelsolin-like 0.488276
FN1 fibronectin 1 0.487886
ADGRG2 adhesion G protein-coupled receptor G2 0.486716
CCL8 chemokine (C-C motif) ligand 8 0.486716
S100A4 S100 calcium binding protein A4 0.480091
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.478923
TGFB1 transforming growth factor, beta 1 0.478534
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.478145
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.477756
IL18BP interleukin 18 binding protein 0.477367
MAB21L2 mab-21-like 2 (C. elegans) 0.471539
AICDA activation-induced cytidine deaminase 0.469987
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 0.469211
TTC34 tetratricopeptide repeat domain 34 0.464561
CAPN8 calpain 8 0.462239
CD5L CD5 molecule-like 0.461852
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.457987
ANXA1 annexin A1 0.456055
CCL7 chemokine (C-C motif) ligand 7 0.45567
FPR2 formyl peptide receptor 2 0.45374
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.452198
ADGRE5 adhesion G protein-coupled receptor E5 0.451428
CXCL12 chemokine (C-X-C motif) ligand 12 0.449501
CCL5 chemokine (C-C motif) ligand 5 0.448346
CXCL5 chemokine (C-X-C motif) ligand 5 0.447576
SH3RF1 SH3 domain containing ring finger 1 0.444884
KANK4 KN motif and ankyrin repeat domains 4 0.439123
CD69 CD69 molecule 0.436055
PARP1 poly (ADP-ribose) polymerase 1 0.434523
BSG basigin (Ok blood group) 0.431077
SAA4 serum amyloid A4, constitutive 0.421148
CCL20 chemokine (C-C motif) ligand 20 0.417337
COMP cartilage oligomeric matrix protein 0.414673
ADAM10 ADAM metallopeptidase domain 10 0.411251
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.407453
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.405935
VEGFA vascular endothelial growth factor A 0.405176
PHB2 prohibitin 2 0.40366
CCRL2 chemokine (C-C motif) receptor-like 2 0.401765
IL16 interleukin 16 0.399114
FLT3LG fms-related tyrosine kinase 3 ligand 0.398735
PRELP proline/arginine-rich end leucine-rich repeat protein 0.396465
HDAC9 histone deacetylase 9 0.393064
MAPK13 mitogen-activated protein kinase 13 0.390421
CTSK cathepsin K 0.387781
IL33 interleukin 33 0.381755
TREX1 three prime repair exonuclease 1 0.377621
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.373493
IL34 interleukin 34 0.373118
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.372743
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.369373
IRF3 interferon regulatory factor 3 0.369373
TNIP1 TNFAIP3 interacting protein 1 0.368624
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.367502
MIR146A microRNA 146a 0.366754
MAP2K7 mitogen-activated protein kinase kinase 7 0.364886
STAT1 signal transducer and activator of transcription 1, 91kDa 0.363393
ALCAM activated leukocyte cell adhesion molecule 0.361901
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.361527
MTX1 metaxin 1 0.359664
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.358546
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.356314
S100A8 S100 calcium binding protein A8 0.353712
SAA1 serum amyloid A1 0.352227
VIP vasoactive intestinal peptide 0.348889
UBE2I ubiquitin-conjugating enzyme E2I 0.344079
IL15 interleukin 15 0.340388
IL17RB interleukin 17 receptor B 0.333763
CXCL9 chemokine (C-X-C motif) ligand 9 0.332294
GDF10 growth differentiation factor 10 0.33156
LPAR1 lysophosphatidic acid receptor 1 0.331194
IL17RA interleukin 17 receptor A 0.328262
CLEC12A C-type lectin domain family 12, member A 0.325701
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.32497
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.319498
SPRED1 sprouty-related, EVH1 domain containing 1 0.318042
DLL3 delta-like 3 (Drosophila) 0.317679
PML promyelocytic leukemia 0.312232
MYD88 myeloid differentiation primary response 88 0.308251
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.306805
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.306083
SNX9 sorting nexin 9 0.306083
CCR1 chemokine (C-C motif) receptor 1 0.300679
CHAD chondroadherin 0.298883
MAPT microtubule-associated protein tau 0.298165
PTGES prostaglandin E synthase 0.29673
BID BH3 interacting domain death agonist 0.292436
CCDC34 coiled-coil domain containing 34 0.290652
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 0.290295
CCR2 chemokine (C-C motif) receptor 2 0.289939
MIR17 microRNA 17 0.288514
C1QA complement component 1, q subcomponent, A chain 0.284607
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.284253
PLA2G10 phospholipase A2, group X 0.28107
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.278955
IL22 interleukin 22 0.278603
TTK TTK protein kinase 0.278251
CALCRL calcitonin receptor-like 0.276495
MIR19A microRNA 19a 0.275444
POU3F3 POU class 3 homeobox 3 0.2723
TIMP2 TIMP metallopeptidase inhibitor 2 0.269867
IRAK3 interleukin-1 receptor-associated kinase 3 0.267791
MDM4 MDM4, p53 regulator 0.267446
FAS Fas cell surface death receptor 0.267446
TYMP thymidine phosphorylase 0.265725
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.265725
CNR2 cannabinoid receptor 2 (macrophage) 0.264353
CD80 CD80 molecule 0.261624
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.259929
CDSN corneodesmosin 0.256902
TRAF3 TNF receptor-associated factor 3 0.256234
CORO1A coronin, actin binding protein, 1A 0.251606
EFNA3 ephrin-A3 0.249977
C5AR1 complement component 5a receptor 1 0.249977
CTSG cathepsin G 0.24486
ADIPOR2 adiponectin receptor 2 0.244545
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 0.243605
SFRP1 secreted frizzled-related protein 1 0.242983
SMS spermine synthase 0.242054
CCL13 chemokine (C-C motif) ligand 13 0.242054
KAT5 K(lysine) acetyltransferase 5 0.238406
CD163 CD163 molecule 0.238406
MIR22 microRNA 22 0.237513
LGALS8 lectin, galactoside-binding, soluble, 8 0.235748
CCL4 chemokine (C-C motif) ligand 4 0.233446
S100A9 S100 calcium binding protein A9 0.232039
PADI2 peptidyl arginine deiminase, type II 0.231206
SOCS3 suppressor of cytokine signaling 3 0.229839
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.227186
IL4 interleukin 4 0.226667
FZD5 frizzled class receptor 5 0.226411
SPP1 secreted phosphoprotein 1 0.225144
TLR9 toll-like receptor 9 0.224645
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.223906
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.223419
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.221291
HOXD10 homeobox D10 0.220831
EZR ezrin 0.220378
HOXD11 homeobox D11 0.217762
ADIPOR1 adiponectin receptor 1 0.217554
SFRP5 secreted frizzled-related protein 5 0.217554
JAK3 Janus kinase 3 0.214017
CD58 CD58 molecule 0.213471
PLA2G2D phospholipase A2, group IID 0.194216
FGL2 fibrinogen-like 2 0.193508
HDAC7 histone deacetylase 7 0.193394
COPS5 COP9 signalosome subunit 5 0.192793
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.186476
CCL17 chemokine (C-C motif) ligand 17 0.186281
RNF2 ring finger protein 2 0.185066
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.183177
CCL22 chemokine (C-C motif) ligand 22 0.182466
B3GAT1 beta-1,3-glucuronyltransferase 1 0.182074
IL27RA interleukin 27 receptor, alpha 0.181567
EGLN2 egl-9 family hypoxia-inducible factor 2 0.181463
MNDA myeloid cell nuclear differentiation antigen 0.181125
HAPLN1 hyaluronan and proteoglycan link protein 1 0.180757
IL10RA interleukin 10 receptor, alpha 0.180378
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.180241
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.180034
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.180034
PSAT1 phosphoserine aminotransferase 1 0.179657
CLEC1B C-type lectin domain family 1, member B 0.179318
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.179097
TRAF2 TNF receptor-associated factor 2 0.179097
WNT1 wingless-type MMTV integration site family, member 1 0.179072
RIPK2 receptor-interacting serine-threonine kinase 2 0.178921
HIST1H1B histone cluster 1, H1b 0.178921
C5 complement component 5 0.178846
CXCL11 chemokine (C-X-C motif) ligand 11 0.178719
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.178487
SUMO3 small ubiquitin-like modifier 3 0.178487
ICOSLG inducible T-cell co-stimulator ligand 0.178251
CLU clusterin 0.178145
DDR2 discoidin domain receptor tyrosine kinase 2 0.178118
BMX BMX non-receptor tyrosine kinase 0.178012
HYAL2 hyaluronoglucosaminidase 2 0.178012
RGMB repulsive guidance molecule family member b 0.177876
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.177876
A2M alpha-2-macroglobulin 0.177822
ADM adrenomedullin 0.177795
IL5 interleukin 5 0.177182
POSTN periostin, osteoblast specific factor 0.176838
SUMO2 small ubiquitin-like modifier 2 0.176455
PARG poly (ADP-ribose) glycohydrolase 0.176213
EGLN3 egl-9 family hypoxia-inducible factor 3 0.175689
SFRP4 secreted frizzled-related protein 4 0.175595
UCN3 urocortin 3 0.17508
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.174684
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.174651
CD200R1 CD200 receptor 1 0.174651
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.174346
SIRT6 sirtuin 6 0.173965
LPAR2 lysophosphatidic acid receptor 2 0.173576
CD40LG CD40 ligand 0.172657
ACAN aggrecan 0.171606
HDAC11 histone deacetylase 11 0.171403
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.171322
MST1 macrophage stimulating 1 0.171282
IGFBP7 insulin-like growth factor binding protein 7 0.171201
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.171078
LHX2 LIM homeobox 2 0.170827
MAPK11 mitogen-activated protein kinase 11 0.170827
HOXD13 homeobox D13 0.17066
TLR7 toll-like receptor 7 0.170576
IL13 interleukin 13 0.170318
RFC2 replication factor C (activator 1) 2, 40kDa 0.170318
KLRG1 killer cell lectin-like receptor subfamily G, member 1 0.170059
GLS glutaminase 0.170016
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.168755
CD86 CD86 molecule 0.16852
NELFCD negative elongation factor complex member C/D 0.168236
AGER advanced glycosylation end product-specific receptor 0.168046
FGF5 fibroblast growth factor 5 0.167998