rheumatoid arthritis disease specific synovial tissue Gene Set

Dataset TISSUES Curated Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Chronic inflammatory disease in which there is destruction of joints. Considered by some to be an autoimmune disorder in which immune complexes are formed in joints and excite an inflammatory response (complex mediated hypersensitivity). Cell-mediated (type IV) hypersensitivity also occurs and macrophages accumulate. This in turn leads to the destruction of the synovial lining. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003702)
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Genes

6 proteins highly expressed in the tissue rheumatoid arthritis disease specific synovial tissue from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.

Symbol Name
CILP2 cartilage intermediate layer protein 2
CTSC cathepsin C
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15
MMP19 matrix metallopeptidase 19
PCOLCE2 procollagen C-endopeptidase enhancer 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)