A heart valve disease that is characterized by repeated inflammation with fibrinous repair. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.It is caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. (Human Disease Ontology, DOID_0050827)
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15 genes associated with the disease rheumatic heart disease in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.