retinal pigment epithelium Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The pigment cell layer that nourishes the retinal cells, located just outside the retina and attached to the choroid. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001177)
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Genes

728 proteins co-occuring with the tissue retinal pigment epithelium in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
RPE65 retinal pigment epithelium-specific protein 65kDa 3.10405
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.56424
RLBP1 retinaldehyde binding protein 1 2.54478
RHO rhodopsin 2.43903
BEST1 bestrophin 1 2.32794
RBP3 retinol binding protein 3, interstitial 2.03482
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 1.99747
RGR retinal G protein coupled receptor 1.97095
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 1.90966
VEGFA vascular endothelial growth factor A 1.90187
MERTK MER proto-oncogene, tyrosine kinase 1.87598
TYR tyrosinase 1.74925
MITF microphthalmia-associated transcription factor 1.71738
CHM choroideremia (Rab escort protein 1) 1.66907
CFH complement factor H 1.65857
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 1.62058
FGF2 fibroblast growth factor 2 (basic) 1.57846
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 1.56086
TJP1 tight junction protein 1 1.51569
MYO7A myosin VIIA 1.50811
MFRP membrane frizzled-related protein 1.49726
SAG S-antigen; retina and pineal gland (arrestin) 1.45844
TYRP1 tyrosinase-related protein 1 1.44821
TGFB2 transforming growth factor, beta 2 1.44543
FN1 fibronectin 1 1.40018
TIMP3 TIMP metallopeptidase inhibitor 3 1.3554
CTSD cathepsin D 1.34179
RRH retinal pigment epithelium-derived rhodopsin homolog 1.31874
OCLN occludin 1.31198
PRPH2 peripherin 2 (retinal degeneration, slow) 1.30703
TGFB1 transforming growth factor, beta 1 1.28636
VSX2 visual system homeobox 2 1.27157
NRL neural retina leucine zipper 1.27023
CRX cone-rod homeobox 1.26665
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 1.26531
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1.26263
ELOVL4 ELOVL fatty acid elongase 4 1.25771
RDH8 retinol dehydrogenase 8 (all-trans) 1.24208
HTRA1 HtrA serine peptidase 1 1.22069
C8ORF37 chromosome 8 open reading frame 37 1.21668
TULP1 tubby like protein 1 1.21535
OTX2 orthodenticle homeobox 2 1.20245
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.18468
RBP1 retinol binding protein 1, cellular 1.16914
OPTC opticin 1.16781
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 1.16205
CCL2 chemokine (C-C motif) ligand 2 1.15052
IL1B interleukin 1, beta 1.13324
PAX6 paired box 6 1.11154
RPGR retinitis pigmentosa GTPase regulator 1.10845
PRCD progressive rod-cone degeneration 1.09872
NR2E3 nuclear receptor subfamily 2, group E, member 3 1.08457
ICAM1 intercellular adhesion molecule 1 1.07132
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.06382
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 1.0625
GLB1 galactosidase, beta 1 1.05853
BEST2 bestrophin 2 1.04488
MMP2 matrix metallopeptidase 2 1.03653
GFAP glial fibrillary acidic protein 1.02688
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 1.02469
TNF tumor necrosis factor 1.02118
RAB27A RAB27A, member RAS oncogene family 1.01375
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 1.00545
ANXA5 annexin A5 1.00414
IMPG2 interphotoreceptor matrix proteoglycan 2 1.0037
SOD2 superoxide dismutase 2, mitochondrial 1.00283
HMOX1 heme oxygenase 1 1.00152
CES1 carboxylesterase 1 0.99978
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 0.994989
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.994989
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 0.992814
RDH10 retinol dehydrogenase 10 (all-trans) 0.991074
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.981084
LINC00575 long intergenic non-protein coding RNA 575 0.980217
SBSPON somatomedin B and thrombospondin, type 1 domain containing 0.980217
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 0.97935
GLB1L3 galactosidase, beta 1-like 3 0.961175
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 0.956859
KRT18 keratin 18, type I 0.952116
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.946947
CTGF connective tissue growth factor 0.943935
GLB1L2 galactosidase, beta 1-like 2 0.936629
DNAH8 dynein, axonemal, heavy chain 8 0.934911
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 0.933195
GPR143 G protein-coupled receptor 143 0.92805
FGF1 fibroblast growth factor 1 (acidic) 0.92291
GRAMD3 GRAM domain containing 3 0.917779
MLPH melanophilin 0.914788
CLDN1 claudin 1 0.913933
CLDN7 claudin 7 0.906682
ALB albumin 0.893496
RCVRN recoverin 0.892223
RAI14 retinoic acid induced 14 0.891798
FLT1 fms-related tyrosine kinase 1 0.889253
FASLG Fas ligand (TNF superfamily, member 6) 0.886286
HMCN1 hemicentin 1 0.879089
SEBOX SEBOX homeobox 0.878243
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.873172
MREG melanoregulin 0.869794
STRA6 stimulated by retinoic acid 6 0.869373
ROM1 retinal outer segment membrane protein 1 0.856312
TTR transthyretin 0.840769
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.839091
IGF1 insulin-like growth factor 1 (somatomedin C) 0.838672
BEST4 bestrophin 4 0.837833
GLB1L galactosidase, beta 1-like 0.836575
CFB complement factor B 0.836156
MMP9 matrix metallopeptidase 9 0.832385
LCA5 Leber congenital amaurosis 5 0.830709
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 0.829872
CAT catalase 0.826942
CRYAB crystallin, alpha B 0.821921
OCA2 oculocutaneous albinism II 0.820666
CXCL8 chemokine (C-X-C motif) ligand 8 0.81983
ERF Ets2 repressor factor 0.809386
GLUL glutamate-ammonia ligase 0.804796
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 0.803127
FTH1 ferritin, heavy polypeptide 1 0.802293
CLDN19 claudin 19 0.801459
IMPG1 interphotoreceptor matrix proteoglycan 1 0.801042
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.798125
FGF5 fibroblast growth factor 5 0.792293
TIMP1 TIMP metallopeptidase inhibitor 1 0.784388
TSHZ2 teashirt zinc finger homeobox 2 0.780648
FTL ferritin, light polypeptide 0.774834
ZNF644 zinc finger protein 644 0.773174
C1QTNF9B C1q and tumor necrosis factor related protein 9B 0.771514
KIZ kizuna centrosomal protein 0.771514
GAS6 growth arrest-specific 6 0.769441
SCARB1 scavenger receptor class B, member 1 0.767783
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.765711
THBS1 thrombospondin 1 0.764882
ARR3 arrestin 3, retinal (X-arrestin) 0.759914
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.758259
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.758259
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.751645
RBP4 retinol binding protein 4, plasma 0.749166
PDGFC platelet derived growth factor C 0.747927
OPN4 opsin 4 0.745451
ARSB arylsulfatase B 0.741327
GRK1 G protein-coupled receptor kinase 1 0.732677
IL6 interleukin 6 0.732265
VEGFB vascular endothelial growth factor B 0.731442
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 0.728563
POC1B POC1 centriolar protein B 0.727741
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 0.726918
BAX BCL2-associated X protein 0.723631
PCNA proliferating cell nuclear antigen 0.718703
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.716651
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 0.7146
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.70845
BSG basigin (Ok blood group) 0.707631
GUCA1A guanylate cyclase activator 1A (retina) 0.704764
CFHR1 complement factor H-related 1 0.704764
GCLC glutamate-cysteine ligase, catalytic subunit 0.696581
CD46 CD46 molecule, complement regulatory protein 0.693719
DNTT DNA nucleotidylexotransferase 0.693311
FBLN5 fibulin 5 0.692493
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.691676
FGFR1 fibroblast growth factor receptor 1 0.690042
ACPP acid phosphatase, prostate 0.685143
KRT8 keratin 8, type II 0.683919
NES nestin 0.68188
CD68 CD68 molecule 0.677803
RAP2A RAP2A, member of RAS oncogene family 0.670471
CLDN3 claudin 3 0.670064
PLAT plasminogen activator, tissue 0.66925
DDIT3 DNA-damage-inducible transcript 3 0.660304
JUN jun proto-oncogene 0.6461
AXL AXL receptor tyrosine kinase 0.6461
MYO5A myosin VA (heavy chain 12, myoxin) 0.6461
MFGE8 milk fat globule-EGF factor 8 protein 0.644479
CFHR3 complement factor H-related 3 0.644074
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 0.642858
BCL2L1 BCL2-like 1 0.640428
KEAP1 kelch-like ECH-associated protein 1 0.639214
HEPH hephaestin 0.638809
CRYBA1 crystallin, beta A1 0.63638
BDNF brain-derived neurotrophic factor 0.635167
CNTF ciliary neurotrophic factor 0.630718
TFRC transferrin receptor 0.629506
C3 complement component 3 0.628293
C10ORF11 chromosome 10 open reading frame 11 0.627485
SCARB2 scavenger receptor class B, member 2 0.626273
CLDN20 claudin 20 0.624254
NRBF2 nuclear receptor binding factor 2 0.621831
LHFPL5 lipoma HMGIC fusion partner-like 5 0.620621
TXN thioredoxin 0.6182
GLOD4 glyoxalase domain containing 4 0.617796
F13B coagulation factor XIII, B polypeptide 0.61699
NFE2L2 nuclear factor, erythroid 2-like 2 0.60893
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.604904
ZBED4 zinc finger, BED-type containing 4 0.604502
TSPO translocator protein (18kDa) 0.603697
CNGB3 cyclic nucleotide gated channel beta 3 0.600881
CPNE8 copine VIII 0.600479
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 0.600077
DES desmin 0.59646
NDP Norrie disease (pseudoglioma) 0.59646
TLR3 toll-like receptor 3 0.59405
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.592444
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 0.590437
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.589635
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 0.589234
GJA1 gap junction protein, alpha 1, 43kDa 0.589234
EZR ezrin 0.585625
MSRB2 methionine sulfoxide reductase B2 0.584823
MYRIP myosin VIIA and Rab interacting protein 0.584422
HSPA4 heat shock 70kDa protein 4 0.583621
VCL vinculin 0.583621
HFE2 hemochromatosis type 2 (juvenile) 0.58322
LRRN4 leucine rich repeat neuronal 4 0.582019
ELANE elastase, neutrophil expressed 0.579216
TFE3 transcription factor binding to IGHM enhancer 3 0.578416
MET MET proto-oncogene, receptor tyrosine kinase 0.574416
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.568424
OAT ornithine aminotransferase 0.568424
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.567626
HFE hemochromatosis 0.566828
PDGFB platelet-derived growth factor beta polypeptide 0.564434
CRYAA crystallin, alpha A 0.562042
CTSS cathepsin S 0.562042
CD36 CD36 molecule (thrombospondin receptor) 0.560847
KDR kinase insert domain receptor 0.558856
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.558059
SMAD2 SMAD family member 2 0.557661
GUSB glucuronidase, beta 0.557263
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.556865
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.556467
GPR75 G protein-coupled receptor 75 0.550503
RPE ribulose-5-phosphate-3-epimerase 0.549709
APC adenomatous polyposis coli 0.548517
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.546929
ZC3H11A zinc finger CCCH-type containing 11A 0.544549
PSIP1 PC4 and SFRS1 interacting protein 1 0.540981
DCT dopachrome tautomerase 0.540981
VEGFC vascular endothelial growth factor C 0.539793
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.537416
CEP290 centrosomal protein 290kDa 0.535438
SEC13 SEC13 homolog (S. cerevisiae) 0.534647
AQP12A aquaporin 12A 0.533856
RAB28 RAB28, member RAS oncogene family 0.531089
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.531089
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.525955
SH3BP4 SH3-domain binding protein 4 0.525166
VASH1 vasohibin 1 0.524377
ERP29 endoplasmic reticulum protein 29 0.5228
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.521617
ADAMTSL4 ADAMTS-like 4 0.520829
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.519647
MRC1 mannose receptor, C type 1 0.519647
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.519253
ENO2 enolase 2 (gamma, neuronal) 0.517678
RABL2B RAB, member of RAS oncogene family-like 2B 0.516497
RABL2A RAB, member of RAS oncogene family-like 2A 0.516497
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.51453
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.513743
PGF placental growth factor 0.506672
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 0.506279
EMP2 epithelial membrane protein 2 0.503141
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.501965
FYCO1 FYVE and coiled-coil domain containing 1 0.499223
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.49844
COL18A1 collagen, type XVIII, alpha 1 0.495701
CD59 CD59 molecule, complement regulatory protein 0.494528
CNGA3 cyclic nucleotide gated channel alpha 3 0.494528
GDNF glial cell derived neurotrophic factor 0.490229
CFI complement factor I 0.489057
CD44 CD44 molecule (Indian blood group) 0.488276
FOLR1 folate receptor 1 (adult) 0.484376
FOS FBJ murine osteosarcoma viral oncogene homolog 0.483986
NEUROD1 neuronal differentiation 1 0.483206
PLA2G12B phospholipase A2, group XIIB 0.476201
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.476201
INS insulin 0.475034
VAX1 ventral anterior homeobox 1 0.475034
CST3 cystatin C 0.473092
RP1L1 retinitis pigmentosa 1-like 1 0.470763
CLEC18A C-type lectin domain family 18, member A 0.470375
APOE apolipoprotein E 0.468436
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 0.465723
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.461465
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.461078
ORAI1 ORAI calcium release-activated calcium modulator 1 0.459532
PITPNM3 PITPNM family member 3 0.458373
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.457214
MT1A metallothionein 1A 0.456828
CP ceruloplasmin (ferroxidase) 0.454126
ALPPL2 alkaline phosphatase, placental-like 2 0.453355
SOX2 SRY (sex determining region Y)-box 2 0.452584
ALPL alkaline phosphatase, liver/bone/kidney 0.452584
SLC39A2 solute carrier family 39 (zinc transporter), member 2 0.452198
ALPP alkaline phosphatase, placental 0.451813
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.451428
RET ret proto-oncogene 0.449501
FGF9 fibroblast growth factor 9 0.444884
RBM39 RNA binding motif protein 39 0.441426
TF transferrin 0.441042
MT2A metallothionein 2A 0.436822
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.436438
IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker) 0.435672
MSRA methionine sulfoxide reductase A 0.434523
OPTN optineurin 0.429547
GPX4 glutathione peroxidase 4 0.429547
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.427636
CD81 CD81 molecule 0.424199
FAM161A family with sequence similarity 161, member A 0.423818
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 0.423818
KIF16B kinesin family member 16B 0.419623
GPX1 glutathione peroxidase 1 0.416576
ACER2 alkaline ceramidase 2 0.415814
CD4 CD4 molecule 0.415053
ANK1 ankyrin 1, erythrocytic 0.413912
CNRIP1 cannabinoid receptor interacting protein 1 0.412771
HCAR2 hydroxycarboxylic acid receptor 2 0.412771
CCR2 chemokine (C-C motif) receptor 2 0.412391
JAM3 junctional adhesion molecule 3 0.409731
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.409351
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.407073
CARD17 caspase recruitment domain family, member 17 0.404039
GPX5 glutathione peroxidase 5 0.40328
CXCL12 chemokine (C-X-C motif) ligand 12 0.402144
RHD Rh blood group, D antigen 0.400628
VIP vasoactive intestinal peptide 0.40025
PLAU plasminogen activator, urokinase 0.399114
ADM adrenomedullin 0.398735
TP53 tumor protein p53 0.3976
AQP11 aquaporin 11 0.396844
DXO decapping exoribonuclease 0.394576
MLXIPL MLX interacting protein-like 0.391176
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.390799
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.389666
NOTCH1 notch 1 0.389289
TFEC transcription factor EC 0.386273
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.385896
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 0.385143
ITGA1 integrin, alpha 1 0.384766
EYS eyes shut homolog (Drosophila) 0.38326
STAT1 signal transducer and activator of transcription 1, 91kDa 0.380627
MME membrane metallo-endopeptidase 0.379123
MMP1 matrix metallopeptidase 1 0.379123
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.378372
CLIC6 chloride intracellular channel 6 0.377621
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 0.377245
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.37687
SYP synaptophysin 0.37687
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.374993
UPK3B uroplakin 3B 0.371245
EFS embryonal Fyn-associated substrate 0.370496
BCO1 beta-carotene oxygenase 1 0.36825
SQSTM1 sequestosome 1 0.367876
SIRT1 sirtuin 1 0.366007
VWF von Willebrand factor 0.36526
TFR2 transferrin receptor 2 0.363766
ATG5 autophagy related 5 0.36302
CALB1 calbindin 1, 28kDa 0.358919
ACAD9 acyl-CoA dehydrogenase family, member 9 0.358174
HPS1 Hermansky-Pudlak syndrome 1 0.356686
ADAM9 ADAM metallopeptidase domain 9 0.35557
TYRO3 TYRO3 protein tyrosine kinase 0.355198
OTX1 orthodenticle homeobox 1 0.354455
NGF nerve growth factor (beta polypeptide) 0.352227
APOB apolipoprotein B 0.351856
BBS5 Bardet-Biedl syndrome 5 0.351485
HLA-B major histocompatibility complex, class I, B 0.34926
CDHR1 cadherin-related family member 1 0.348889
NRP1 neuropilin 1 0.348148
AQP4 aquaporin 4 0.345928
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 0.345928
EDA ectodysplasin A 0.344079
RAX retina and anterior neural fold homeobox 0.34334
TIMP2 TIMP metallopeptidase inhibitor 2 0.341863
RIMS1 regulating synaptic membrane exocytosis 1 0.341126
LHX2 LIM homeobox 2 0.340757
BEND3 BEN domain containing 3 0.3356
TERT telomerase reverse transcriptase 0.335233
BCO2 beta-carotene oxygenase 2 0.334865
ELN elastin 0.333763
CD58 CD58 molecule 0.333763
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.333028
ATF4 activating transcription factor 4 0.333028
HAMP hepcidin antimicrobial peptide 0.333028
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.331927
SPATA4 spermatogenesis associated 4 0.331194
ARL6 ADP-ribosylation factor-like 6 0.329727
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.327896
NRTN neurturin 0.326432
TFPI2 tissue factor pathway inhibitor 2 0.326067
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.325335
PARP1 poly (ADP-ribose) polymerase 1 0.324239
AQP6 aquaporin 6, kidney specific 0.323509
MSN moesin 0.323509
PADI2 peptidyl arginine deiminase, type II 0.323144
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.322779
RPL30 ribosomal protein L30 0.322414
OPN1MW2 opsin 1 (cone pigments), medium-wave-sensitive 2 0.32132
CRYGS crystallin, gamma S 0.320956
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 0.320591
BBS1 Bardet-Biedl syndrome 1 0.320227
CTSB cathepsin B 0.319863
CERK ceramide kinase 0.31877
SUCNR1 succinate receptor 1 0.318042
IQCB1 IQ motif containing B1 0.318042
NT5E 5'-nucleotidase, ecto (CD73) 0.317679
ANLN anillin, actin binding protein 0.314772
MTNR1A melatonin receptor 1A 0.314046
CRYBB2 crystallin, beta B2 0.313683
MSI1 musashi RNA-binding protein 1 0.31332
MMP3 matrix metallopeptidase 3 0.312957
OPN1MW opsin 1 (cone pigments), medium-wave-sensitive 0.312232
GCLM glutamate-cysteine ligase, modifier subunit 0.31187
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 0.311507
BMP4 bone morphogenetic protein 4 0.311145
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 0.309697
ACTG1 actin gamma 1 0.308251
CERKL ceramide kinase-like 0.307167
CLCN4 chloride channel, voltage-sensitive 4 0.305001
MAPK8 mitogen-activated protein kinase 8 0.305001
LYPLAL1 lysophospholipase-like 1 0.304279
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.304279
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.303919
PLIN2 perilipin 2 0.302478
ADCY2 adenylate cyclase 2 (brain) 0.29996
LGALS3 lectin, galactoside-binding, soluble, 3 0.29996
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 0.297806
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.297089
RGPD1 RANBP2-like and GRIP domain containing 1 0.29673
ATF6 activating transcription factor 6 0.29673
IL17RC interleukin 17 receptor C 0.296372
SHROOM2 shroom family member 2 0.295655
PI3 peptidase inhibitor 3, skin-derived 0.294939
MLANA melan-A 0.294939
OSBP2 oxysterol binding protein 2 0.294223
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 0.293866
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 0.293151
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.292793
SMAD5-AS1 SMAD5 antisense RNA 1 0.292793
GSTA4 glutathione S-transferase alpha 4 0.292793
STIM1 stromal interaction molecule 1 0.292436
PROS1 protein S (alpha) 0.292079
BACE2 beta-site APP-cleaving enzyme 2 0.292079
RANBP2 RAN binding protein 2 0.290295
CTNND1 catenin (cadherin-associated protein), delta 1 0.290295
CA2 carbonic anhydrase II 0.289939
IGFBP5 insulin-like growth factor binding protein 5 0.289939
TJP3 tight junction protein 3 0.28887
ELOVL1 ELOVL fatty acid elongase 1 0.28887
CLEC2B C-type lectin domain family 2, member B 0.288514
RNASEH2A ribonuclease H2, subunit A 0.288158
C3AR1 complement component 3a receptor 1 0.288158
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 0.284962
NGB neuroglobin 0.284607
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.283899
CAV1 caveolin 1, caveolae protein, 22kDa 0.282837
SMAD3 SMAD family member 3 0.281423
KIFC3 kinesin family member C3 0.281423
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.28107
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.279659
TLR4 toll-like receptor 4 0.279307
ELF1 E74-like factor 1 (ets domain transcription factor) 0.278955
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.278955
ASL argininosuccinate lyase 0.278251
NLRP3 NLR family, pyrin domain containing 3 0.277197
TFEB transcription factor EB 0.277197
ARSA arylsulfatase A 0.276145
ACTB actin, beta 0.275794
COL11A1 collagen, type XI, alpha 1 0.275444
IGFBP3 insulin-like growth factor binding protein 3 0.273696
HBA1 hemoglobin, alpha 1 0.271604
PDC phosducin 0.271256
C5AR1 complement component 5a receptor 1 0.271256
SPATA7 spermatogenesis associated 7 0.270909
VIT vitrin 0.270909
PCDH15 protocadherin-related 15 0.270561
TH tyrosine hydroxylase 0.269867
ATG14 autophagy related 14 0.269174
AMPD3 adenosine monophosphate deaminase 3 0.269174
PRPF8 pre-mRNA processing factor 8 0.267446
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.265381
CLRN1 clarin 1 0.265381
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 0.265038
RAB32 RAB32, member RAS oncogene family 0.263669
TSPAN10 tetraspanin 10 0.262986
RDX radixin 0.262986
SST somatostatin 0.261964
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.261284
HBA2 hemoglobin, alpha 2 0.260606
RTN2 reticulon 2 0.260267
PI15 peptidase inhibitor 15 0.259254
SIX3 SIX homeobox 3 0.258917
SIX6 SIX homeobox 6 0.2559
GYPC glycophorin C (Gerbich blood group) 0.2559
HPX hemopexin 0.254902
ABHD6 abhydrolase domain containing 6 0.254239
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 0.253578
RHOD ras homolog family member D 0.25259
IGF2-AS IGF2 antisense RNA 0.250627
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.250301
TXN2 thioredoxin 2 0.249653
TPST2 tyrosylprotein sulfotransferase 2 0.247399
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 0.245807
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.245807
NEUROG1 neurogenin 1 0.243605
CRYZ crystallin, zeta (quinone reductase) 0.243605
COL1A1 collagen, type I, alpha 1 0.242983
SLC16A4 solute carrier family 16, member 4 0.242054
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.241746
PRPF31 pre-mRNA processing factor 31 0.241438
MYO3A myosin IIIA 0.241438
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.237216
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.236332
ATXN7 ataxin 7 0.23604
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 0.235457
MIPEP mitochondrial intermediate peptidase 0.235457
NF2 neurofibromin 2 (merlin) 0.234878
IDUA iduronidase, alpha-L- 0.234016
VAV3 vav 3 guanine nucleotide exchange factor 0.233446
LRP6 low density lipoprotein receptor-related protein 6 0.233446
SOX10 SRY (sex determining region Y)-box 10 0.233446
ADRA1D adrenoceptor alpha 1D 0.232881
CTBP2 C-terminal binding protein 2 0.23176
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.23176
ARL3 ADP-ribosylation factor-like 3 0.231482
IGF1R insulin-like growth factor 1 receptor 0.231206
CHKB choline kinase beta 0.230382
BCL2 B-cell CLL/lymphoma 2 0.229032
IRF1 interferon regulatory factor 1 0.22797
TRPM3 transient receptor potential cation channel, subfamily M, member 3 0.227445
BDH2 3-hydroxybutyrate dehydrogenase, type 2 0.227445
MXD1 MAX dimerization protein 1 0.226926
FTMT ferritin mitochondrial 0.226667
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.225395
RARS arginyl-tRNA synthetase 0.224893
IGFBP6 insulin-like growth factor binding protein 6 0.22415
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.223662
HMOX2 heme oxygenase 2 0.223419
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.222938
BDKRB2 bradykinin receptor B2 0.222699
GUCA2A guanylate cyclase activator 2A (guanylin) 0.222699
PMM1 phosphomannomutase 1 0.221755
ZEB1 zinc finger E-box binding homeobox 1 0.220604
C1R complement component 1, r subcomponent 0.220378
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.219047
LAMA3 laminin, alpha 3 0.218398
TGFBI transforming growth factor, beta-induced, 68kDa 0.218186
CLU clusterin 0.217974
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.217762
HDGF hepatoma-derived growth factor 0.217346
ANG angiogenin, ribonuclease, RNase A family, 5 0.21673
PLG plasminogen 0.21673
EYA3 EYA transcriptional coactivator and phosphatase 3 0.216528
IFNB1 interferon, beta 1, fibroblast 0.216325
TPST1 tyrosylprotein sulfotransferase 1 0.216325
GSTA1 glutathione S-transferase alpha 1 0.216325
NPPA natriuretic peptide A 0.215534
ITGAV integrin, alpha V 0.215147
ATF3 activating transcription factor 3 0.214954
CNTLN centlein, centrosomal protein 0.214954
PLA2G12A phospholipase A2, group XIIA 0.214576
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.214388
LAMB2 laminin, beta 2 (laminin S) 0.214388
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.214388
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.213471
WFDC1 WAP four-disulfide core domain 1 0.213112
HYAL3 hyaluronoglucosaminidase 3 0.201241
BDKRB1 bradykinin receptor B1 0.198035
ELF5 E74-like factor 5 (ets domain transcription factor) 0.196693
EHF ets homologous factor 0.196365
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.195999
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.19532
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.194051
SEMG1 semenogelin I 0.192979
ALOX15B arachidonate 15-lipoxygenase, type B 0.191645
FBXL15 F-box and leucine-rich repeat protein 15 0.191325
HAT1 histone acetyltransferase 1 0.189442
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.189211
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.188014
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.187036
CIITA class II, major histocompatibility complex, transactivator 0.18606
CDON cell adhesion associated, oncogene regulated 0.185711
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.185472
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 0.185027
FGFR3 fibroblast growth factor receptor 3 0.184987
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.184956
ACP2 acid phosphatase 2, lysosomal 0.183721
FGFR2 fibroblast growth factor receptor 2 0.177561
ARSI arylsulfatase family, member I 0.177268
PDE5A phosphodiesterase 5A, cGMP-specific 0.176455
RARA retinoic acid receptor, alpha 0.176349
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.174833
EPHA6 EPH receptor A6 0.173067
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.172041
MIRLET7E microRNA let-7e 0.171302
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 0.170275
MIRLET7D microRNA let-7d 0.169685
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.169054
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.168962
ERVW-1 endogenous retrovirus group W, member 1 0.168962
SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.167924
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.167361
SUMF1 sulfatase modifying factor 1 0.167337
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.167337
MIR26B microRNA 26b 0.167261
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.166806
RARB retinoic acid receptor, beta 0.165924
BAMBI BMP and activin membrane-bound inhibitor 0.165574
STAT4 signal transducer and activator of transcription 4 0.164557
MIR15B microRNA 15b 0.164045
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.162386
STIM2 stromal interaction molecule 2 0.160322
NFIB nuclear factor I/B 0.157416
CARM1 coactivator-associated arginine methyltransferase 1 0.1572
NFIA nuclear factor I/A 0.156755
MIRLET7B microRNA let-7b 0.156311
LEFTY2 left-right determination factor 2 0.155818
FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.155051
CLDN4 claudin 4 0.154972
UBC ubiquitin C 0.154264
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 0.153418
RPS27A ribosomal protein S27a 0.153377
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.153337
PRKCG protein kinase C, gamma 0.153053
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.152972
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 0.152722
BTC betacellulin 0.151761
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.151631
CDC14A cell division cycle 14A 0.151631
ATG7 autophagy related 7 0.151502
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.151373
HADH hydroxyacyl-CoA dehydrogenase 0.150899
CPT1C carnitine palmitoyltransferase 1C 0.150727
PMP22 peripheral myelin protein 22 0.149978
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.149978
UBB ubiquitin B 0.149934
LYN LYN proto-oncogene, Src family tyrosine kinase 0.149712
TNNT1 troponin T type 1 (skeletal, slow) 0.149446
RSAD2 radical S-adenosyl methionine domain containing 2 0.148492
TMEM11 transmembrane protein 11 0.148264
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 0.147941
BPI bactericidal/permeability-increasing protein 0.147894
MT4 metallothionein 4 0.147003
SMAD7 SMAD family member 7 0.146956
MYCBP MYC binding protein 0.146672
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.146238
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.146238
TMSB10 thymosin beta 10 0.146141
BBC3 BCL2 binding component 3 0.145756
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.145611
VSIG4 V-set and immunoglobulin domain containing 4 0.145515
PDCD1LG2 programmed cell death 1 ligand 2 0.144526
PXN paxillin 0.144081
CRHR2 corticotropin releasing hormone receptor 2 0.144031
RPL11 ribosomal protein L11 0.14398
PARD3 par-3 family cell polarity regulator 0.143522
SRPK1 SRSF protein kinase 1 0.143216
IGFBP7 insulin-like growth factor binding protein 7 0.142962
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 0.14281
COL4A1 collagen, type IV, alpha 1 0.142708
ETNK1 ethanolamine kinase 1 0.142553
ELAVL1 ELAV like RNA binding protein 1 0.142188
WRN Werner syndrome, RecQ helicase-like 0.142135
GSK3B glycogen synthase kinase 3 beta 0.141718
ACTA1 actin, alpha 1, skeletal muscle 0.141457
IL13RA1 interleukin 13 receptor, alpha 1 0.141301
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.140875
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 0.140768
COL1A2 collagen, type I, alpha 2 0.140768
MTTP microsomal triglyceride transfer protein 0.140714
OAF OAF homolog (Drosophila) 0.140661
PPP6C protein phosphatase 6, catalytic subunit 0.139912
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 0.139805
IL1A interleukin 1, alpha 0.139642
SRRM1 serine/arginine repetitive matrix 1 0.139588
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.139203
DCX doublecortin 0.139203
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.139093
PPP5C protein phosphatase 5, catalytic subunit 0.138764
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.138545
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.138048
CXCL6 chemokine (C-X-C motif) ligand 6 0.137992
CCND1 cyclin D1 0.137879
ANXA11 annexin A11 0.137767
HBEGF heparin-binding EGF-like growth factor 0.137767
GPC4 glypican 4 0.137542
TGFB3 transforming growth factor, beta 3 0.137317
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.137261
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.13698
POU2F3 POU class 2 homeobox 3 0.136868
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.136529
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 0.136414
MYL9 myosin, light chain 9, regulatory 0.136011
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.135608
RB1 retinoblastoma 1 0.135378
IGKV3-20 immunoglobulin kappa variable 3-20 0.134916
KNG1 kininogen 1 0.134739
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.134504
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.133974
SIVA1 SIVA1, apoptosis-inducing factor 0.133915
NTN4 netrin 4 0.133445
DNA2 DNA replication helicase/nuclease 2 0.133386
UNC5A unc-5 homolog A (C. elegans) 0.133386
TNC tenascin C 0.133266
PNPLA2 patatin-like phospholipase domain containing 2 0.132844
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.132303
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.132003
FAAH fatty acid amide hydrolase 0.131763
GABPB1 GA binding protein transcription factor, beta subunit 1 0.131763
RPS3 ribosomal protein S3 0.130842
XBP1 X-box binding protein 1 0.130596
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.130351
CD48 CD48 molecule 0.130044
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.130044
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.129417
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.129103
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 0.128415
ESAM endothelial cell adhesion molecule 0.128352
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 0.12797
BSN bassoon presynaptic cytomatrix protein 0.127394
RIPK3 receptor-interacting serine-threonine kinase 3 0.1265
PPP4C protein phosphatase 4, catalytic subunit 0.125978
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.125848
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 0.125717
ZMYND10 zinc finger, MYND-type containing 10 0.125392
LTB4R leukotriene B4 receptor 0.125327
UCN urocortin 0.124937
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.124609
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.124543
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.124344