retinal neovascularization Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina (Mammalian Phenotype Ontology, MP_0008852)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008852
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Genes

32 gene mutations causing the retinal neovascularization phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ANGPT2 angiopoietin 2
ANGPTL4 angiopoietin-like 4
ANPEP alanyl (membrane) aminopeptidase
APOE apolipoprotein E
BCL2 B-cell CLL/lymphoma 2
BMPER BMP binding endothelial regulator
CBS cystathionine-beta-synthase
CDH13 cadherin 13
CISD2 CDGSH iron sulfur domain 2
DLL4 delta-like 4 (Drosophila)
F3 coagulation factor III (thromboplastin, tissue factor)
H2AFX H2A histone family, member X
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KLHL20 kelch-like family member 20
LIF leukemia inhibitory factor
LIMK2 LIM domain kinase 2
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOSTRIN nitric oxide synthase trafficking
NRARP NOTCH-regulated ankyrin repeat protein
NRP1 neuropilin 1
OPTC opticin
PRPH2 peripherin 2 (retinal degeneration, slow)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPL24 ribosomal protein L24
TGFA transforming growth factor, alpha
VLDLR very low density lipoprotein receptor