response to toxic substance Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. (Gene Ontology, GO_0009636)
External Link http://amigo.geneontology.org/amigo/term/GO:0009636
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Genes

134 genes participating in the response to toxic substance biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADRB3 adrenoceptor beta 3
AHR aryl hydrocarbon receptor
ALPL alkaline phosphatase, liver/bone/kidney
AOC1 amine oxidase, copper containing 1
AOC3 amine oxidase, copper containing 3
AQP10 aquaporin 10
ARG1 arginase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BLMH bleomycin hydrolase
BPHL biphenyl hydrolase-like (serine hydrolase)
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCNB1 cyclin B1
CCR4 chemokine (C-C motif) receptor 4
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CERS1 ceramide synthase 1
CES1 carboxylesterase 1
CHUK conserved helix-loop-helix ubiquitous kinase
CIITA class II, major histocompatibility complex, transactivator
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CPOX coproporphyrinogen oxidase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CYB5R4 cytochrome b5 reductase 4
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DRD2 dopamine receptor D2
EGR1 early growth response 1
ENDOG endonuclease G
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC6 excision repair cross-complementation group 6
FAS Fas cell surface death receptor
FECH ferrochelatase
FOS FBJ murine osteosarcoma viral oncogene homolog
GJC2 gap junction protein, gamma 2, 47kDa
GLYAT glycine-N-acyltransferase
GPX1 glutathione peroxidase 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GUCY2C guanylate cyclase 2C
HDAC6 histone deacetylase 6
HID1 HID1 domain containing
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTRA2 HtrA serine peptidase 2
HYAL1 hyaluronoglucosaminidase 1
HYAL2 hyaluronoglucosaminidase 2
HYAL3 hyaluronoglucosaminidase 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL6 interleukin 6
INMT indolethylamine N-methyltransferase
JAK1 Janus kinase 1
JAK2 Janus kinase 2
LCN2 lipocalin 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAOB monoamine oxidase B
MAPK1 mitogen-activated protein kinase 1
MAPK9 mitogen-activated protein kinase 9
MBP myelin basic protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MGMT O-6-methylguanine-DNA methyltransferase
MPST mercaptopyruvate sulfurtransferase
MYDGF myeloid-derived growth factor
NEFL neurofilament, light polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPRD1 opioid receptor, delta 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDZD3 PDZ domain containing 3
PINK1 PTEN induced putative kinase 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4F phospholipase A2, group IVF
PLK1 polo-like kinase 1
PON1 paraoxonase 1
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PTGR1 prostaglandin reductase 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RSRC1 arginine/serine-rich coiled-coil 1
SCFD1 sec1 family domain containing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SCN2B sodium channel, voltage gated, type II beta subunit
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDC1 syndecan 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC30A4 solute carrier family 30 (zinc transporter), member 4
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOD1 superoxide dismutase 1, soluble
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAR steroidogenic acute regulatory protein
TH tyrosine hydroxylase
TK1 thymidine kinase 1, soluble
TLR2 toll-like receptor 2
TP53 tumor protein p53
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TTPA tocopherol (alpha) transfer protein
TYMS thymidylate synthetase
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
UROS uroporphyrinogen III synthase
WAPAL wings apart-like homolog (Drosophila)
XBP1 X-box binding protein 1
XPA xeroderma pigmentosum, complementation group A
ZC3H8 zinc finger CCCH-type containing 8