response to metal ion Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. (Gene Ontology, GO_0010038)
External Link http://amigo.geneontology.org/amigo/term/GO:0010038
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Genes

254 genes participating in the response to metal ion biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
ABAT 4-aminobutyrate aminotransferase
ACER1 alkaline ceramidase 1
ACO1 aconitase 1, soluble
ACTA1 actin, alpha 1, skeletal muscle
ADAM9 ADAM metallopeptidase domain 9
ADCY1 adenylate cyclase 1 (brain)
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase
ALOX15 arachidonate 15-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA11 annexin A11
ANXA7 annexin A7
AOC1 amine oxidase, copper containing 1
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
AQP1 aquaporin 1 (Colton blood group)
AQP2 aquaporin 2 (collecting duct)
AQP3 aquaporin 3 (Gill blood group)
AQP9 aquaporin 9
ARG1 arginase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
ATF1 activating transcription factor 1
ATP13A2 ATPase type 13A2
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATP7B ATPase, Cu++ transporting, beta polypeptide
B2M beta-2-microglobulin
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP6 bone morphogenetic protein 6
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BSG basigin (Ok blood group)
CA2 carbonic anhydrase II
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACYBP calcyclin binding protein
CALR calreticulin
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAPN3 calpain 3, (p94)
CARF calcium responsive transcription factor
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASQ2 calsequestrin 2 (cardiac muscle)
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1 cyclin B1
CCND1 cyclin D1
CD14 CD14 molecule
CD86 CD86 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHP2 calcineurin-like EF-hand protein 2
CLIC4 chloride intracellular channel 4
CNGA3 cyclic nucleotide gated channel alpha 3
CPOX coproporphyrinogen oxidase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CREB1 cAMP responsive element binding protein 1
CRHBP corticotropin releasing hormone binding protein
CRIP1 cysteine-rich protein 1 (intestinal)
CRP C-reactive protein, pentraxin-related
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUTA cutA divalent cation tolerance homolog (E. coli)
CYB5A cytochrome b5 type A (microsomal)
CYBRD1 cytochrome b reductase 1
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
D2HGDH D-2-hydroxyglutarate dehydrogenase
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
DMTN dematin actin binding protein
DPEP1 dipeptidase 1 (renal)
DRD2 dopamine receptor D2
DTYMK deoxythymidylate kinase (thymidylate kinase)
DUSP1 dual specificity phosphatase 1
ECT2 epithelial cell transforming 2
EDN1 endothelin 1
EGFR epidermal growth factor receptor
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FBP1 fructose-1,6-bisphosphatase 1
FECH ferrochelatase
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FKBP1A FK506 binding protein 1A, 12kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FSTL3 follistatin-like 3 (secreted glycoprotein)
FXN frataxin
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDI1 GDP dissociation inhibitor 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GIPR gastric inhibitory polypeptide receptor
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
GSS glutathione synthetase
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HTT huntingtin
HVCN1 hydrogen voltage gated channel 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1A interleukin 1, alpha
IL4 interleukin 4
IL6 interleukin 6
IQGAP1 IQ motif containing GTPase activating protein 1
IREB2 iron-responsive element binding protein 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNIP2 Kv channel interacting protein 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KRT10 keratin 10, type I
KRT14 keratin 14, type I
LCE1D late cornified envelope 1D
LCK LCK proto-oncogene, Src family tyrosine kinase
LIG4 ligase IV, DNA, ATP-dependent
LONP1 lon peptidase 1, mitochondrial
LOXL2 lysyl oxidase-like 2
LRRK2 leucine-rich repeat kinase 2
MAOB monoamine oxidase B
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MBP myelin basic protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
MNAT1 MNAT CDK-activating kinase assembly factor 1
MT1A metallothionein 1A
MT1B metallothionein 1B
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MT3 metallothionein 3
MTF1 metal-regulatory transcription factor 1
MTL5 metallothionein-like 5, testis-specific (tesmin)
MYOG myogenin (myogenic factor 4)
NDRG1 N-myc downstream regulated 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEUROD2 neuronal differentiation 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPC1 Niemann-Pick disease, type C1
NPTX1 neuronal pentraxin I
OGG1 8-oxoguanine DNA glycosylase
OTC ornithine carbamoyltransferase
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARK2 parkin RBR E3 ubiquitin protein ligase
PCNA proliferating cell nuclear antigen
PDCD6 programmed cell death 6
PDX1 pancreatic and duodenal homeobox 1
PEF1 penta-EF-hand domain containing 1
PGAM2 phosphoglycerate mutase 2 (muscle)
PKLR pyruvate kinase, liver and RBC
PLN phospholamban
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRNP prion protein
PTEN phosphatase and tensin homolog
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTK2B protein tyrosine kinase 2 beta
QDPR quinoid dihydropteridine reductase
RASA4 RAS p21 protein activator 4
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
S100A13 S100 calcium binding protein A13
S100A16 S100 calcium binding protein A16
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCN5A sodium channel, voltage gated, type V alpha subunit
SDC1 syndecan 1
SEC31A SEC31 homolog A (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHH sonic hedgehog
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPHK1 sphingosine kinase 1
STAR steroidogenic acute regulatory protein
STIM1 stromal interaction molecule 1
SYT1 synaptotagmin I
SYT3 synaptotagmin III
TAT tyrosine aminotransferase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TH tyrosine hydroxylase
THBS1 thrombospondin 1
TK1 thymidine kinase 1, soluble
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNNC1 troponin C type 1 (slow)
TNNT2 troponin T type 2 (cardiac)
TPH2 tryptophan hydroxylase 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TSHB thyroid stimulating hormone, beta
TSPO translocator protein (18kDa)
TTN titin
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZACN zinc activated ligand-gated ion channel