response to hypoxia Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. (Gene Ontology, GO_0001666)
External Link http://amigo.geneontology.org/amigo/term/GO:0001666
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Genes

239 genes participating in the response to hypoxia biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAA2 acetyl-CoA acyltransferase 2
ACSL6 acyl-CoA synthetase long-chain family member 6
ACTN4 actinin, alpha 4
ADA adenosine deaminase
ADAM17 ADAM metallopeptidase domain 17
ADAM8 ADAM metallopeptidase domain 8
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA1 adenosine A1 receptor
AGTRAP angiotensin II receptor-associated protein
AHCY adenosylhomocysteinase
AJUBA ajuba LIM protein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAS2 5'-aminolevulinate synthase 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ALKBH5 AlkB family member 5, RNA demethylase
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPT2 angiopoietin 2
ANGPT4 angiopoietin 4
ANGPTL4 angiopoietin-like 4
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
ARNT aryl hydrocarbon receptor nuclear translocator
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASCL2 achaete-scute family bHLH transcription factor 2
ATM ATM serine/threonine kinase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BIRC2 baculoviral IAP repeat containing 2
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA9 carbonic anhydrase IX
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAPN2 calpain 2, (m/II) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCNB1 cyclin B1
CD24 CD24 molecule
CD38 CD38 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA1 chloride channel accessory 1
CLDN3 claudin 3
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPEB2 cytoplasmic polyadenylation element binding protein 2
CREBBP CREB binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CRYAB crystallin, alpha B
CUL2 cullin 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DPP4 dipeptidyl-peptidase 4
DRD2 dopamine receptor D2
E2F1 E2F transcription factor 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP1 fatty acid binding protein 1, liver
FAM162A family with sequence similarity 162, member A
FMN2 formin 2
FNDC1 fibronectin type III domain containing 1
FUNDC1 FUN14 domain containing 1
GATA6 GATA binding protein 6
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIF3A hypoxia inducible factor 3, alpha subunit
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIPK2 homeodomain interacting protein kinase 2
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HP1BP3 heterochromatin protein 1, binding protein 3
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IRAK1 interleukin-1 receptor-associated kinase 1
IREB2 iron-responsive element binding protein 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LEP leptin
LIMD1 LIM domains containing 1
LMNA lamin A/C
LONP1 lon peptidase 1, mitochondrial
LOXL2 lysyl oxidase-like 2
LTA lymphotoxin alpha
MB myoglobin
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MECP2 methyl CpG binding protein 2
MGARP mitochondria-localized glutamic acid-rich protein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MT3 metallothionein 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYOCD myocardin
NARFL nuclear prelamin A recognition factor-like
NDRG1 N-myc downstream regulated 1
NF1 neurofibromin 1
NKX3-1 NK3 homeobox 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOX4 NADPH oxidase 4
NPEPPS aminopeptidase puromycin sensitive
NPPA natriuretic peptide A
NPPC natriuretic peptide C
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRF1 nuclear respiratory factor 1
OPRD1 opioid receptor, delta 1
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3
P4HB prolyl 4-hydroxylase, beta polypeptide
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDLIM1 PDZ and LIM domain 1
PGF placental growth factor
PINK1 PTEN induced putative kinase 1
PKLR pyruvate kinase, liver and RBC
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCE protein kinase C, epsilon
PSEN2 presenilin 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RBX1 ring-box 1, E3 ubiquitin protein ligase
RGCC regulator of cell cycle
RORA RAR-related orphan receptor A
RPS27A ribosomal protein S27a
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
S100B S100 calcium binding protein B
SCAP SREBF chaperone
SCFD1 sec1 family domain containing 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD9 SMAD family member 9
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAT5B signal transducer and activator of transcription 5B
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TBL2 transducin (beta)-like 2
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TEK TEK tyrosine kinase, endothelial
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR3 transforming growth factor, beta receptor III
TH tyrosine hydroxylase
THBS1 thrombospondin 1
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TRH thyrotropin-releasing hormone
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TSC2 tuberous sclerosis 2
TWIST1 twist family bHLH transcription factor 1
TXN2 thioredoxin 2
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2B ubiquitin-conjugating enzyme E2B
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBQLN1 ubiquilin 1
UCN2 urocortin 2
UCN3 urocortin 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
USF1 upstream transcription factor 1
UTS2 urotensin 2
VASN vasorin
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WTIP Wilms tumor 1 interacting protein