respiratory failure Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A lung disease characterized by inadequate gas exchange by the respiratory system. (Human Disease Ontology, DOID_11162)
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Genes

718 genes co-occuring with the disease respiratory failure in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SFTPB surfactant protein B 2.35924
ALB albumin 2.12965
SFTPC surfactant protein C 1.84727
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.83727
ELANE elastase, neutrophil expressed 1.82595
TNF tumor necrosis factor 1.82233
MPO myeloperoxidase 1.72593
CXCL8 chemokine (C-X-C motif) ligand 8 1.6936
IL1B interleukin 1, beta 1.59921
C5AR1 complement component 5a receptor 1 1.55291
IL6 interleukin 6 1.54318
TTN titin 1.52336
F3 coagulation factor III (thromboplastin, tissue factor) 1.45924
SOD2 superoxide dismutase 2, mitochondrial 1.45792
PROS2P protein S (beta) pseudogene 1.45441
SFTPD surfactant protein D 1.45397
ACE angiotensin I converting enzyme 1.3904
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.38996
CRP C-reactive protein, pentraxin-related 1.35986
AQP5 aquaporin 5 1.35202
IGHMBP2 immunoglobulin mu binding protein 2 1.2944
GAA glucosidase, alpha; acid 1.28916
PLA2G1B phospholipase A2, group IB (pancreas) 1.28261
ICAM1 intercellular adhesion molecule 1 1.28217
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.27257
SFTPA1 surfactant protein A1 1.27257
NPPA natriuretic peptide A 1.26168
F2 coagulation factor II (thrombin) 1.25384
FGF7 fibroblast growth factor 7 1.23516
TF transferrin 1.1841
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.18195
CAT catalase 1.17378
CSAD cysteine sulfinic acid decarboxylase 1.16264
THBD thrombomodulin 1.1456
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.11856
AQP1 aquaporin 1 (Colton blood group) 1.11772
BCHE butyrylcholinesterase 1.10594
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 1.10594
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.1051
PLG plasminogen 1.10048
DNAH8 dynein, axonemal, heavy chain 8 1.08076
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 1.0627
A1BG alpha-1-B glycoprotein 1.06186
PLAT plasminogen activator, tissue 1.05723
FN1 fibronectin 1 1.05471
CD4 CD4 molecule 1.04966
INS insulin 1.03746
IL10 interleukin 10 1.02861
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.02482
PPCS phosphopantothenoylcysteine synthetase 1.0109
AGER advanced glycosylation end product-specific receptor 1.00203
NKX2-1 NK2 homeobox 1 0.999924
SELL selectin L 0.992752
KNG1 kininogen 1 0.99233
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.988535
PLA2G10 phospholipase A2, group X 0.985164
AVP arginine vasopressin 0.984321
IL2 interleukin 2 0.98011
HMOX1 heme oxygenase 1 0.968341
MMP9 matrix metallopeptidase 9 0.963728
ACE2 angiotensin I converting enzyme 2 0.960378
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.935799
TLR4 toll-like receptor 4 0.929587
MUC1 mucin 1, cell surface associated 0.916375
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.915963
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.911022
IL1A interleukin 1, alpha 0.90732
CDH5 cadherin 5, type 2 (vascular endothelium) 0.900746
EDN1 endothelin 1 0.900335
NOS3 nitric oxide synthase 3 (endothelial cell) 0.891718
ACHE acetylcholinesterase (Yt blood group) 0.888029
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.885979
MED27 mediator complex subunit 27 0.881062
ANGPT2 angiopoietin 2 0.876557
MLX MLX, MAX dimerization protein 0.876557
HMGB1 high mobility group box 1 0.873691
KIAA0101 KIAA0101 0.868777
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.866731
TRH thyrotropin-releasing hormone 0.861818
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.856497
KLK15 kallikrein-related peptidase 15 0.846669
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.842163
CDKN2A cyclin-dependent kinase inhibitor 2A 0.831099
MYLK myosin light chain kinase 0.829459
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.816334
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.815514
REN renin 0.808129
VWF von Willebrand factor 0.801154
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.798282
TAC1 tachykinin, precursor 1 0.792541
CCL3 chemokine (C-C motif) ligand 3 0.785574
PCYT1B phosphate cytidylyltransferase 1, choline, beta 0.781888
LBR lamin B receptor 0.781888
CCL2 chemokine (C-C motif) ligand 2 0.780251
HBA2 hemoglobin, alpha 2 0.774114
TGFB1 transforming growth factor, beta 1 0.773705
MYLK3 myosin light chain kinase 3 0.770027
GPX5 glutathione peroxidase 5 0.76921
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.767576
GPX4 glutathione peroxidase 4 0.765943
GPX1 glutathione peroxidase 1 0.763902
CHPT1 choline phosphotransferase 1 0.760231
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.758193
VEGFA vascular endothelial growth factor A 0.757378
C9ORF3 chromosome 9 open reading frame 3 0.745985
SELE selectin E 0.745172
SMOX spermine oxidase 0.741517
MB myoglobin 0.738271
TEF thyrotrophic embryonic factor 0.736649
NOS2 nitric oxide synthase 2, inducible 0.736649
PHF14 PHD finger protein 14 0.726929
ANGPT1 angiopoietin 1 0.726929
MMP12 matrix metallopeptidase 12 0.725716
POMC proopiomelanocortin 0.725311
RAB3C RAB3C, member RAS oncogene family 0.724907
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.72329
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.722077
ANK1 ankyrin 1, erythrocytic 0.720865
XKR3 XK, Kell blood group complex subunit-related family, member 3 0.712392
ACO2 aconitase 2, mitochondrial 0.709975
MMP2 matrix metallopeptidase 2 0.708767
MYRF myelin regulatory factor 0.70233
GPR162 G protein-coupled receptor 162 0.696306
SFTPA2 surfactant protein A2 0.687091
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.684692
CLDN18 claudin 18 0.683892
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.681894
COX5A cytochrome c oxidase subunit Va 0.681894
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.678701
ALPL alkaline phosphatase, liver/bone/kidney 0.678302
AMY2A amylase, alpha 2A (pancreatic) 0.677903
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.673518
NPR1 natriuretic peptide receptor 1 0.672722
GUCY2C guanylate cyclase 2C 0.671527
SEPN1 selenoprotein N, 1 0.670732
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.666755
TIMP1 TIMP metallopeptidase inhibitor 1 0.660008
ALPPL2 alkaline phosphatase, placental-like 2 0.658026
ALPP alkaline phosphatase, placental 0.65763
PAOX polyamine oxidase (exo-N4-amino) 0.65565
CTSG cathepsin G 0.640645
CLDN5 claudin 5 0.636708
CXCL10 chemokine (C-X-C motif) ligand 10 0.630027
ARHGAP35 Rho GTPase activating protein 35 0.629635
FTL ferritin, light polypeptide 0.627672
GSN gelsolin 0.626888
FTH1 ferritin, heavy polypeptide 1 0.625319
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.617486
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) 0.615921
MGME1 mitochondrial genome maintenance exonuclease 1 0.613183
ARMCX5 armadillo repeat containing, X-linked 5 0.612792
TNNT2 troponin T type 2 (cardiac) 0.61162
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.61162
PPP6R2 protein phosphatase 6, regulatory subunit 2 0.610448
HLA-C major histocompatibility complex, class I, C 0.608104
MAPK14 mitogen-activated protein kinase 14 0.605372
CD79A CD79a molecule, immunoglobulin-associated alpha 0.604591
HSPA4 heat shock 70kDa protein 4 0.60342
TNNI3 troponin I type 3 (cardiac) 0.59991
HABP2 hyaluronan binding protein 2 0.597571
MMP8 matrix metallopeptidase 8 0.597571
FGF10 fibroblast growth factor 10 0.597181
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.596012
STK40 serine/threonine kinase 40 0.595623
MTM1 myotubularin 1 0.594843
PRTN3 proteinase 3 0.594454
DNM1 dynamin 1 0.593674
VCAM1 vascular cell adhesion molecule 1 0.589779
GLS2 glutaminase 2 (liver, mitochondrial) 0.58939
F8 coagulation factor VIII, procoagulant component 0.587833
IL1RN interleukin 1 receptor antagonist 0.583552
ACTA1 actin, alpha 1, skeletal muscle 0.582384
EDNRA endothelin receptor type A 0.580439
CXCR2 chemokine (C-X-C motif) receptor 2 0.569552
GUSB glucuronidase, beta 0.560616
CP ceruloplasmin (ferroxidase) 0.556732
TTR transthyretin 0.55518
CSF3 colony stimulating factor 3 (granulocyte) 0.548195
DMD dystrophin 0.545093
IL2RA interleukin 2 receptor, alpha 0.544705
OR1A1 olfactory receptor, family 1, subfamily A, member 1 0.540442
BHLHB9 basic helix-loop-helix domain containing, class B, 9 0.540442
FMO5 flavin containing monooxygenase 5 0.540442
MYOT myotilin 0.540055
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.53657
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.534248
IL36B interleukin 36, beta 0.525746
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.524974
OR7E87P olfactory receptor, family 7, subfamily E, member 87 pseudogene 0.523045
POLB polymerase (DNA directed), beta 0.522273
FLNC filamin C, gamma 0.519961
OCLN occludin 0.518805
MGAM maltase-glucoamylase 0.51842
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.516494
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.514571
ARHGAP24 Rho GTPase activating protein 24 0.509576
CD59 CD59 molecule, complement regulatory protein 0.508808
CXCL2 chemokine (C-X-C motif) ligand 2 0.507273
F5 coagulation factor V (proaccelerin, labile factor) 0.50689
CD68 CD68 molecule 0.501527
LSR lipolysis stimulated lipoprotein receptor 0.499997
CALCA calcitonin-related polypeptide alpha 0.493503
FASLG Fas ligand (TNF superfamily, member 6) 0.493503
POPDC3 popeye domain containing 3 0.490072
PRRC2A proline-rich coiled-coil 2A 0.489691
AZU1 azurocidin 1 0.489691
HSPA1A heat shock 70kDa protein 1A 0.48893
SOX18 SRY (sex determining region Y)-box 18 0.488549
LTF lactotransferrin 0.483224
GRP gastrin-releasing peptide 0.482844
KRT75 keratin 75, type II 0.482084
C4A complement component 4A (Rodgers blood group) 0.481325
TSPO translocator protein (18kDa) 0.480945
RAB9A RAB9A, member RAS oncogene family 0.476014
LDHC lactate dehydrogenase C 0.476014
FLT1 fms-related tyrosine kinase 1 0.475634
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.472225
PGF placental growth factor 0.470332
BPI bactericidal/permeability-increasing protein 0.467306
FMO1 flavin containing monooxygenase 1 0.465038
F12 coagulation factor XII (Hageman factor) 0.46466
ESAM endothelial cell adhesion molecule 0.462394
LYZ lysozyme 0.460129
TARDBP TAR DNA binding protein 0.459373
TJP1 tight junction protein 1 0.457109
PPL periplakin 0.45447
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.453339
SMN2 survival of motor neuron 2, centromeric 0.451078
RSPO2 R-spondin 2 0.446182
ADRB2 adrenoceptor beta 2, surface 0.445429
CXCL5 chemokine (C-X-C motif) ligand 5 0.444676
FGFRL1 fibroblast growth factor receptor-like 1 0.438282
MED26 mediator complex subunit 26 0.436026
NABP2 nucleic acid binding protein 2 0.433772
MAN2A2 mannosidase, alpha, class 2A, member 2 0.433021
TBXAS1 thromboxane A synthase 1 (platelet) 0.430768
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.429642
SFTA3 surfactant associated 3 0.42739
GPRASP2 G protein-coupled receptor associated sorting protein 2 0.42739
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.419892
FMO4 flavin containing monooxygenase 4 0.418768
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 0.418768
CTSC cathepsin C 0.418394
IGF1 insulin-like growth factor 1 (somatomedin C) 0.41465
G6PD glucose-6-phosphate dehydrogenase 0.408292
REXO2 RNA exonuclease 2 0.406051
FMO2 flavin containing monooxygenase 2 (non-functional) 0.400826
SMN1 survival of motor neuron 1, telomeric 0.399707
CLDN4 claudin 4 0.398589
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.397843
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 0.396353
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.395235
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.395235
CXCR1 chemokine (C-X-C motif) receptor 1 0.394863
PER1 period circadian clock 1 0.394118
KIN Kin17 DNA and RNA binding protein 0.391885
DNASE1 deoxyribonuclease I 0.391141
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.388166
IFT81 intraflagellar transport 81 0.387794
SURF1 surfeit 1 0.387794
THEM4 thioesterase superfamily member 4 0.386679
GSR glutathione reductase 0.385936
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.383708
TSC2 tuberous sclerosis 2 0.380739
NAMPT nicotinamide phosphoribosyltransferase 0.380368
FOXA2 forkhead box A2 0.379997
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.379997
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.379626
CORO1A coronin, actin binding protein, 1A 0.379626
LTA lymphotoxin alpha 0.378143
ERAS ES cell expressed Ras 0.377031
KLHL17 kelch-like family member 17 0.377031
DSP desmoplakin 0.375179
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.374438
MME membrane metallo-endopeptidase 0.374438
S100A12 S100 calcium binding protein A12 0.373698
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.373698
JUN jun proto-oncogene 0.373328
STAT1 signal transducer and activator of transcription 1, 91kDa 0.371847
HAT1 histone acetyltransferase 1 0.371847
PKDCC protein kinase domain containing, cytoplasmic 0.368518
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.368149
UBQLN3 ubiquilin 3 0.368149
CBX1 chromobox homolog 1 0.366671
C6ORF25 chromosome 6 open reading frame 25 0.366301
FXYD1 FXYD domain containing ion transport regulator 1 0.366301
SOD3 superoxide dismutase 3, extracellular 0.365932
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.365562
PPAN peter pan homolog (Drosophila) 0.364085
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.360026
PI3 peptidase inhibitor 3, skin-derived 0.359657
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.35892
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.358183
EGFR epidermal growth factor receptor 0.356709
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.356341
NXF3 nuclear RNA export factor 3 0.351923
PLAU plasminogen activator, urokinase 0.35082
RERE arginine-glutamic acid dipeptide (RE) repeats 0.349717
GCLC glutamate-cysteine ligase, catalytic subunit 0.345308
ADM adrenomedullin 0.344941
HRH2 histamine receptor H2 0.344574
SP3 Sp3 transcription factor 0.344574
ECEL1 endothelin converting enzyme-like 1 0.342372
TLX3 T-cell leukemia homeobox 3 0.340906
CHKA choline kinase alpha 0.33944
PHF5A PHD finger protein 5A 0.337608
ARSD arylsulfatase D 0.33651
PLA2G4D phospholipase A2, group IVD (cytosolic) 0.335046
DLL1 delta-like 1 (Drosophila) 0.334315
PFDN4 prefoldin subunit 4 0.331756
MUSK muscle, skeletal, receptor tyrosine kinase 0.331391
OR13H1 olfactory receptor, family 13, subfamily H, member 1 0.331025
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.32774
GPRASP1 G protein-coupled receptor associated sorting protein 1 0.326281
RAB3D RAB3D, member RAS oncogene family 0.325552
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.325187
CLEC7A C-type lectin domain family 7, member A 0.32373
TMEM38A transmembrane protein 38A 0.323365
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.322273
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.320454
TREM1 triggering receptor expressed on myeloid cells 1 0.318635
LIG3 ligase III, DNA, ATP-dependent 0.318272
HBA1 hemoglobin, alpha 1 0.317909
CARD17 caspase recruitment domain family, member 17 0.317909
LARS leucyl-tRNA synthetase 0.315729
CTNND1 catenin (cadherin-associated protein), delta 1 0.312464
PBX3 pre-B-cell leukemia homeobox 3 0.311014
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.31029
CD34 CD34 molecule 0.309204
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.307033
HP haptoglobin 0.307033
ADI1 acireductone dioxygenase 1 0.30631
B2M beta-2-microglobulin 0.305948
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.305948
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.305587
DNTT DNA nucleotidylexotransferase 0.305587
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.304142
HPR haptoglobin-related protein 0.300894
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.300894
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.300173
VTA1 vesicle (multivesicular body) trafficking 1 0.299092
SNX5 sorting nexin 5 0.298371
PIH2 pregnancy-induced hypertension syndrome-related protein 0.296211
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.295851
WBP2 WW domain binding protein 2 0.295492
TFCP2 transcription factor CP2 0.295492
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 0.293694
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.292975
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.292616
NOX1 NADPH oxidase 1 0.291539
USP33 ubiquitin specific peptidase 33 0.290821
GC group-specific component (vitamin D binding protein) 0.290462
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.290103
KDR kinase insert domain receptor 0.289744
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.287593
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.287235
TACR1 tachykinin receptor 1 0.286877
TJP2 tight junction protein 2 0.28616
OSCAR osteoclast associated, immunoglobulin-like receptor 0.285802
PDE5A phosphodiesterase 5A, cGMP-specific 0.285802
CASR calcium-sensing receptor 0.284013
NEUROD1 neuronal differentiation 1 0.284013
FBXL20 F-box and leucine-rich repeat protein 20 0.283655
HAND2 heart and neural crest derivatives expressed 2 0.282582
PROCR protein C receptor, endothelial 0.280796
COPA coatomer protein complex, subunit alpha 0.278654
F9 coagulation factor IX 0.27794
OXTR oxytocin receptor 0.277227
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 0.276514
ATP11A ATPase, class VI, type 11A 0.276514
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.276158
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.275801
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.275801
ACVR2B activin A receptor, type IIB 0.27153
PDGFB platelet-derived growth factor beta polypeptide 0.270464
GSX2 GS homeobox 2 0.269043
NFYC nuclear transcription factor Y, gamma 0.266558
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.264785
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.264431
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.261952
MOB3B MOB kinase activator 3B 0.261245
KLHL20 kelch-like family member 20 0.260891
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 0.260891
C1S complement component 1, s subcomponent 0.260538
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.260184
CLEC4M C-type lectin domain family 4, member M 0.259477
WAPAL wings apart-like homolog (Drosophila) 0.259477
STK10 serine/threonine kinase 10 0.259124
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.255594
RAB3B RAB3B, member RAS oncogene family 0.254536
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.253831
ADA adenosine deaminase 0.252774
CDCA3 cell division cycle associated 3 0.25207
TARM1 T cell-interacting, activating receptor on myeloid cells 1 0.251015
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.251015
PDZK1IP1 PDZK1 interacting protein 1 0.250311
PTH parathyroid hormone 0.248554
TOB1 transducer of ERBB2, 1 0.247501
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.247501
ASIC2 acid sensing (proton gated) ion channel 2 0.246799
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.246448
ADORA2B adenosine A2b receptor 0.245046
NCAM2 neural cell adhesion molecule 2 0.244696
APEH acylaminoacyl-peptide hydrolase 0.244345
FOXM1 forkhead box M1 0.243995
TPM3 tropomyosin 3 0.242595
PF4 platelet factor 4 0.241895
C5 complement component 5 0.241546
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.241196
AREG amphiregulin 0.240497
MTMR14 myotubularin related protein 14 0.23945
CAV1 caveolin 1, caveolae protein, 22kDa 0.23945
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 0.239101
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.237706
CCL4 chemokine (C-C motif) ligand 4 0.237706
NOTCH1 notch 1 0.235616
SMAD2 SMAD family member 2 0.233878
BIN2 bridging integrator 2 0.232142
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.230755
FGFR4 fibroblast growth factor receptor 4 0.230063
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.227988
SAP18 Sin3A-associated protein, 18kDa 0.227297
CYGB cytoglobin 0.225573
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.222479
CCDC40 coiled-coil domain containing 40 0.222136
IL4 interleukin 4 0.22145
MRPL49 mitochondrial ribosomal protein L49 0.22145
CD19 CD19 molecule 0.22145
EPHX2 epoxide hydrolase 2, cytoplasmic 0.220424
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.220424
SLPI secretory leukocyte peptidase inhibitor 0.220081
ECI1 enoyl-CoA delta isomerase 1 0.220081
PPARG peroxisome proliferator-activated receptor gamma 0.219057
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.218374
CTGF connective tissue growth factor 0.218034
NOX4 NADPH oxidase 4 0.217352
IPP intracisternal A particle-promoted polypeptide 0.217352
C3 complement component 3 0.215653
ENO2 enolase 2 (gamma, neuronal) 0.214975
IGLV5-48 immunoglobulin lambda variable 5-48 (non-functional) 0.214975
WNT7B wingless-type MMTV integration site family, member 7B 0.214636
NEB nebulin 0.214297
SGK1 serum/glucocorticoid regulated kinase 1 0.212945
SCARB2 scavenger receptor class B, member 2 0.212608
KLHL2 kelch-like family member 2 0.212608
RNASE3 ribonuclease, RNase A family, 3 0.212608
C9ORF72 chromosome 9 open reading frame 72 0.212271
LDHD lactate dehydrogenase D 0.210925
LBP lipopolysaccharide binding protein 0.210589
DUOX2 dual oxidase 2 0.208914
VIP vasoactive intestinal peptide 0.208914
GYPA glycophorin A (MNS blood group) 0.207912
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.207578
KRT84 keratin 84, type II 0.205916
PER2 period circadian clock 2 0.205585
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 0.204923
CEPT1 choline/ethanolamine phosphotransferase 1 0.203604
EBF1 early B-cell factor 1 0.203275
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.202946
AHR aryl hydrocarbon receptor 0.201635
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.201308
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.200331
DCTN1 dynactin 1 0.200331
CD7 CD7 molecule 0.200006
ADORA2A adenosine A2a receptor 0.199356
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.198709
DSPP dentin sialophosphoprotein 0.198709
CDAN1 codanin 1 0.198064
PARP1 poly (ADP-ribose) polymerase 1 0.198064
SAMD4B sterile alpha motif domain containing 4B 0.19742
SST somatostatin 0.196139
AQP4 aquaporin 4 0.195183
VCL vinculin 0.194548
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.192971
RRBP1 ribosome binding protein 1 0.192657
GGT1 gamma-glutamyltransferase 1 0.192344
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.190168
FOXP3 forkhead box P3 0.189244
IL18 interleukin 18 0.188938
CPVL carboxypeptidase, vitellogenic-like 0.188022
RGS8 regulator of G-protein signaling 8 0.188022
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.187415
TG thyroglobulin 0.187113
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.18651
NPS neuropeptide S 0.18651
TIMP2 TIMP metallopeptidase inhibitor 2 0.18621
IFNA1 interferon, alpha 1 0.18621
GPANK1 G patch domain and ankyrin repeats 1 0.185313
NPPB natriuretic peptide B 0.184424
GATA6 GATA binding protein 6 0.184128
MAPK6 mitogen-activated protein kinase 6 0.183835
WRAP73 WD repeat containing, antisense to TP73 0.183541
SLBP stem-loop binding protein 0.183248
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.182666
MYOD1 myogenic differentiation 1 0.182666
MYD88 myeloid differentiation primary response 88 0.182375
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.180652
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.180367
LAMA2 laminin, alpha 2 0.179802
LCN2 lipocalin 2 0.179802
PRF1 perforin 1 (pore forming protein) 0.17896
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.178682
RPH3A rabphilin 3A 0.177576
ITGB6 integrin, beta 6 0.177576
NCAM1 neural cell adhesion molecule 1 0.177029
ESM1 endothelial cell-specific molecule 1 0.174881
PLBD2 phospholipase B domain containing 2 0.174617
DSG3 desmoglein 3 0.174354
LY96 lymphocyte antigen 96 0.172799
TIAM1 T-cell lymphoma invasion and metastasis 1 0.172038
NAAA N-acylethanolamine acid amidase 0.170789
FOXF1 forkhead box F1 0.169812
ALK anaplastic lymphoma receptor tyrosine kinase 0.169812
COL25A1 collagen, type XXV, alpha 1 0.169571
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.169091
POMP proteasome maturation protein 0.167224
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.167224
TMEM53 transmembrane protein 53 0.166544
TRIM37 tripartite motif containing 37 0.166095
VCAN versican 0.165435
HES5 hes family bHLH transcription factor 5 0.165217
ACAN aggrecan 0.164571
ZC3H12D zinc finger CCCH-type containing 12D 0.162908
PDE4A phosphodiesterase 4A, cAMP-specific 0.162707
UST uronyl-2-sulfotransferase 0.161716
CFB complement factor B 0.160948
PRL prolactin 0.160761
PROS1 protein S (alpha) 0.160574
OIT3 oncoprotein induced transcript 3 0.160021
BCL3 B-cell CLL/lymphoma 3 0.159658
APOH apolipoprotein H (beta-2-glycoprotein I) 0.15948
PNMA1 paraneoplastic Ma antigen 1 0.159124
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.159124
ARHGAP21 Rho GTPase activating protein 21 0.158951
AMPH amphiphysin 0.158434
DCT dopachrome tautomerase 0.158097
COL1A2 collagen, type I, alpha 2 0.157929
ABR active BCR-related 0.157765
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 0.143514
TRPS1 trichorhinophalangeal syndrome I 0.143192
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 0.143066
SMAD5 SMAD family member 5 0.143029
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.142821
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.142697
MED19 mediator complex subunit 19 0.14233
SBDS Shwachman-Bodian-Diamond syndrome 0.141943
WIF1 WNT inhibitory factor 1 0.141311
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.138884
IPO13 importin 13 0.138478
ISX intestine-specific homeobox 0.138448
INPP5J inositol polyphosphate-5-phosphatase J 0.138332
CDH8 cadherin 8, type 2 0.137922
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.137676
NPSR1 neuropeptide S receptor 1 0.137528
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.136501
BMP4 bone morphogenetic protein 4 0.13589
TADA3 transcriptional adaptor 3 0.135791
EMX1 empty spiracles homeobox 1 0.135668
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.13559
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.135464
SLC38A4 solute carrier family 38, member 4 0.135253
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.134977
TPM1 tropomyosin 1 (alpha) 0.134779
CLDN3 claudin 3 0.134551
LDHAL6B lactate dehydrogenase A-like 6B 0.134538
LIMA1 LIM domain and actin binding 1 0.134447
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.134264
INSM1 insulinoma-associated 1 0.134237
PRAMEF6 PRAME family member 6 0.134076
S1PR1 sphingosine-1-phosphate receptor 1 0.134022
ITM2B integral membrane protein 2B 0.134008
MLN motilin 0.133966
ZSCAN1 zinc finger and SCAN domain containing 1 0.133939
H1FX H1 histone family, member X 0.133911
HOXB8 homeobox B8 0.133588
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 0.13356
DLX1 distal-less homeobox 1 0.133371
GPX2 glutathione peroxidase 2 0.133313
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.133223
FMO3 flavin containing monooxygenase 3 0.132997
LECT1 leukocyte cell derived chemotaxin 1 0.132967
NOVA1 neuro-oncological ventral antigen 1 0.132671
FAT2 FAT atypical cadherin 2 0.13264
CCDC34 coiled-coil domain containing 34 0.132529
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.132335
LDHAL6A lactate dehydrogenase A-like 6A 0.132318
TPX2 TPX2, microtubule-associated 0.132237
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.132221
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.132187
MAP2K7 mitogen-activated protein kinase kinase 7 0.132137
ANGPT4 angiopoietin 4 0.13212
EPGN epithelial mitogen 0.132087
NPY neuropeptide Y 0.131936
BAG2 BCL2-associated athanogene 2 0.131643
CYB5A cytochrome b5 type A (microsomal) 0.13143
CSH2 chorionic somatomammotropin hormone 2 0.131413
S1PR3 sphingosine-1-phosphate receptor 3 0.131359
RAB10 RAB10, member RAS oncogene family 0.131269
UBN1 ubinuclein 1 0.131251
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 0.131251
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.131031
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.131013
SULT4A1 sulfotransferase family 4A, member 1 0.130995
FDPS farnesyl diphosphate synthase 0.130863
LRRC38 leucine rich repeat containing 38 0.130863
HOXA4 homeobox A4 0.130768
FBXO8 F-box protein 8 0.130693
ARF5 ADP-ribosylation factor 5 0.130674
WTIP Wilms tumor 1 interacting protein 0.130304
MZF1 myeloid zinc finger 1 0.130284
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.130244
TERT telomerase reverse transcriptase 0.130204
NFIL3 nuclear factor, interleukin 3 regulated 0.130124
KCNRG potassium channel regulator 0.129921
PARP9 poly (ADP-ribose) polymerase family, member 9 0.129818
RBM8A RNA binding motif protein 8A 0.129797
LCMT2 leucine carboxyl methyltransferase 2 0.129756
IL22RA2 interleukin 22 receptor, alpha 2 0.129715
TPRG1L tumor protein p63 regulated 1-like 0.129526
EMILIN1 elastin microfibril interfacer 1 0.129419
NOP2 NOP2 nucleolar protein 0.129291
PRAMEF12 PRAME family member 12 0.129291
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.128874
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.128851
CAPN5 calpain 5 0.128851
TGFBR1 transforming growth factor, beta receptor 1 0.128761
GJA1 gap junction protein, alpha 1, 43kDa 0.12867
INSIG1 insulin induced gene 1 0.128324
KAT5 K(lysine) acetyltransferase 5 0.128254
SSH1 slingshot protein phosphatase 1 0.128113
MYL12B myosin, light chain 12B, regulatory 0.127993
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.127969
RICTOR RPTOR independent companion of MTOR, complex 2 0.127945
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 0.127921
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.127896
ARSI arylsulfatase family, member I 0.127896
OLIG1 oligodendrocyte transcription factor 1 0.127775
FPR2 formyl peptide receptor 2 0.127554
PHF12 PHD finger protein 12 0.127454
ARR3 arrestin 3, retinal (X-arrestin) 0.126816
NPAT nuclear protein, ataxia-telangiectasia locus 0.126684
HRH1 histamine receptor H1 0.126658
ADCY9 adenylate cyclase 9 0.126444
IL18RAP interleukin 18 receptor accessory protein 0.12631
INSIG2 insulin induced gene 2 0.12631
LVRN laeverin 0.126228
ZFP36 ZFP36 ring finger protein 0.126035
PEX10 peroxisomal biogenesis factor 10 0.126007
RALB v-ral simian leukemia viral oncogene homolog B 0.12598
CD226 CD226 molecule 0.125952
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.125842
CSHL1 chorionic somatomammotropin hormone-like 1 0.125814
MTO1 mitochondrial tRNA translation optimization 1 0.125643
TLR5 toll-like receptor 5 0.125329
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.1253
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.125211
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.125034
LDHA lactate dehydrogenase A 0.124798
CHAD chondroadherin 0.124554
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.124524
EGLN1 egl-9 family hypoxia-inducible factor 1 0.124463
LPIN2 lipin 2 0.124463
RIPK3 receptor-interacting serine-threonine kinase 3 0.124371
AQP2 aquaporin 2 (collecting duct) 0.124154
CD209 CD209 molecule 0.124059
LDHB lactate dehydrogenase B 0.123744
MTCH2 mitochondrial carrier 2 0.123712
TRAPPC9 trafficking protein particle complex 9 0.123647
IL18R1 interleukin 18 receptor 1 0.123647
BBS2 Bardet-Biedl syndrome 2 0.123484
PKN1 protein kinase N1 0.123452
NTS neurotensin 0.123452
TRPV6 transient receptor potential cation channel, subfamily V, member 6 0.123386
MIR146A microRNA 146a 0.123354
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.123289
APITD1 apoptosis-inducing, TAF9-like domain 1 0.123256
IGLV5-52 immunoglobulin lambda variable 5-52 0.123223
TRPC7 transient receptor potential cation channel, subfamily C, member 7 0.123191
CKLF chemokine-like factor 0.123125
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.122754
PLCH2 phospholipase C, eta 2 0.12272
SCO2 SCO2 cytochrome c oxidase assembly protein 0.12272
MAP2K2 mitogen-activated protein kinase kinase 2 0.12272
ICT1 immature colon carcinoma transcript 1 0.122619
CKAP2 cytoskeleton associated protein 2 0.122482
CD47 CD47 molecule 0.122342
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.122238
CTTN cortactin 0.121994
MFRP membrane frizzled-related protein 0.121923
CUTA cutA divalent cation tolerance homolog (E. coli) 0.121779
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.121635
PRSS1 protease, serine, 1 (trypsin 1) 0.121599
WRNIP1 Werner helicase interacting protein 1 0.121599
CLDN6 claudin 6 0.121599
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.121527
SSB Sjogren syndrome antigen B (autoantigen La) 0.121236
KLRG1 killer cell lectin-like receptor subfamily G, member 1 0.121236
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.12037
CYBRD1 cytochrome b reductase 1 0.120332
CPB1 carboxypeptidase B1 (tissue) 0.12014
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.119627
LNPEP leucyl/cystinyl aminopeptidase 0.119548
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 0.119508
MMP1 matrix metallopeptidase 1 0.119389
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.119349
CCL22 chemokine (C-C motif) ligand 22 0.119145
CCDC27 coiled-coil domain containing 27 0.118816
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 0.118775
POLL polymerase (DNA directed), lambda 0.118734
MSMB microseminoprotein, beta- 0.118693
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.118693
EGLN2 egl-9 family hypoxia-inducible factor 2 0.118611
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.118357
PXN paxillin 0.118187
HOXA5 homeobox A5 0.118103
KERA keratocan 0.117848
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.117804
CRH corticotropin releasing hormone 0.11776