renal interstitial fibrosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Fibrosis that involves the tubules and interstitial tissue of the kidney. (Human Phenotype Ontology, HP_0005576)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003215
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Genes

39 gene mutations causing the renal interstitial fibrosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGA aspartylglucosaminidase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR2 angiotensin II receptor, type 2
APRT adenine phosphoribosyltransferase
AQP2 aquaporin 2 (collecting duct)
CD151 CD151 molecule (Raph blood group)
CD1D CD1d molecule
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DACT3 dishevelled-binding antagonist of beta-catenin 3
DCN decorin
GDNF glial cell derived neurotrophic factor
GLIS2 GLIS family zinc finger 2
GRHPR glyoxylate reductase/hydroxypyruvate reductase
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCP kielin/chordin-like protein
LAMA5 laminin, alpha 5
LEP leptin
LGMN legumain
LIN7C lin-7 homolog C (C. elegans)
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MPV17 MpV17 mitochondrial inner membrane protein
MYO1E myosin IE
NOS3 nitric oxide synthase 3 (endothelial cell)
NPHP3 nephronophthisis 3 (adolescent)
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REN renin
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SMAD3 SMAD family member 3
TRPV5 transient receptor potential cation channel, subfamily V, member 5
UMOD uromodulin
WT1 Wilms tumor 1
WWTR1 WW domain containing transcription regulator 1
XDH xanthine dehydrogenase