regulation of molecular function, epigenetic Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. (Gene Ontology, GO_0040030)
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2 genes participating in the regulation of molecular function, epigenetic biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ASIP agouti signaling protein
CTCF CCCTC-binding factor (zinc finger protein)