regulation of apoptotic signaling pathway Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. (Gene Ontology, GO_2001233)
External Link http://amigo.geneontology.org/amigo/term/GO:2001233
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Genes

363 genes participating in the regulation of apoptotic signaling pathway biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACKR3 atypical chemokine receptor 3
ACVR1 activin A receptor, type I
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR2 angiotensin II receptor, type 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
APAF1 apoptotic peptidase activating factor 1
APOPT1 apoptogenic 1, mitochondrial
AR androgen receptor
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARRB2 arrestin, beta 2
ATPIF1 ATPase inhibitory factor 1
AVP arginine vasopressin
BAD BCL2-associated agonist of cell death
BAG5 BCL2-associated athanogene 5
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCAP31 B-cell receptor-associated protein 31
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L12 BCL2-like 12 (proline rich)
BCL2L2 BCL2-like 2
BCLAF1 BCL2-associated transcription factor 1
BDKRB2 bradykinin receptor B2
BID BH3 interacting domain death agonist
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC6 baculoviral IAP repeat containing 6
BMF Bcl2 modifying factor
BMP5 bone morphogenetic protein 5
BMPR1B bone morphogenetic protein receptor, type IB
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCAR2 cell cycle and apoptosis regulator 2
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CFLAR CASP8 and FADD-like apoptosis regulator
CIDEB cell death-inducing DFFA-like effector b
CLU clusterin
COL2A1 collagen, type II, alpha 1
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CREB3 cAMP responsive element binding protein 3
CREB3L1 cAMP responsive element binding protein 3-like 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTH cystathionine gamma-lyase
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSC cathepsin C
CTSH cathepsin H
CTTN cortactin
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYLD cylindromatosis (turban tumor syndrome)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAB2IP DAB2 interacting protein
DAPK1 death-associated protein kinase 1
DAPK2 death-associated protein kinase 2
DAPK3 death-associated protein kinase 3
DAXX death-domain associated protein
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDIT3 DNA-damage-inducible transcript 3
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DEDD2 death effector domain containing 2
DEPTOR DEP domain containing MTOR-interacting protein
DFNA5 deafness, autosomal dominant 5
DNM1L dynamin 1-like
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
E2F1 E2F transcription factor 1
EI24 etoposide induced 2.4
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELL3 elongation factor RNA polymerase II-like 3
EPO erythropoietin
EYA1 EYA transcriptional coactivator and phosphatase 1
FADD Fas (TNFRSF6)-associated via death domain
FAF1 Fas (TNFRSF6) associated factor 1
FAIM2 Fas apoptotic inhibitory molecule 2
FAM162A family with sequence similarity 162, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXO18 F-box protein, helicase, 18
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FEM1B fem-1 homolog b (C. elegans)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGF10 fibroblast growth factor 10
FGFR1 fibroblast growth factor receptor 1
FGG fibrinogen gamma chain
FIGNL1 fidgetin-like 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FXN frataxin
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
G2E3 G2/M-phase specific E3 ubiquitin protein ligase
GAS1 growth arrest-specific 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GCG glucagon
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDNF glial cell derived neurotrophic factor
GFRAL GDNF family receptor alpha like
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPER1 G protein-coupled estrogen receptor 1
GPX1 glutathione peroxidase 1
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HDAC2 histone deacetylase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HRK harakiri, BCL2 interacting protein
HSPB1 heat shock 27kDa protein 1
HTRA2 HtrA serine peptidase 2
HTT huntingtin
HYAL2 hyaluronoglucosaminidase 2
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFNB1 interferon, beta 1, fibroblast
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL19 interleukin 19
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL20RA interleukin 20 receptor, alpha
IL4 interleukin 4
IL7 interleukin 7
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1
ING2 inhibitor of growth family, member 2
ING5 inhibitor of growth family, member 5
INHBA inhibin, beta A
INHBB inhibin, beta B
INS insulin
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITM2C integral membrane protein 2C
IVNS1ABP influenza virus NS1A binding protein
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KDM1A lysine (K)-specific demethylase 1A
KIAA1324 KIAA1324
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS3 lectin, galactoside-binding, soluble, 3
LMNA lamin A/C
LRRK2 leucine-rich repeat kinase 2
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MADD MAP-kinase activating death domain
MAGED1 melanoma antigen family D1
MAL mal, T-cell differentiation protein
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK9 mitogen-activated protein kinase 9
MCL1 myeloid cell leukemia 1
MEIS3 Meis homeobox 3
MFF mitochondrial fission factor
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
MNT MAX network transcriptional repressor
MOAP1 modulator of apoptosis 1
MPV17L MPV17 mitochondrial membrane protein-like
MSX1 msh homeobox 1
MUC1 mucin 1, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NANOS3 nanos homolog 3 (Drosophila)
NCK1 NCK adaptor protein 1
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NF1 neurofibromin 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFE2L2 nuclear factor, erythroid 2-like 2
NGFR nerve growth factor receptor
NKX3-1 NK3 homeobox 1
NLE1 notchless homolog 1 (Drosophila)
NME5 NME/NM23 family member 5
NMT1 N-myristoyltransferase 1
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOG noggin
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NONO non-POU domain containing, octamer-binding
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX1 NADPH oxidase 1
NRP1 neuropilin 1
OPA1 optic atrophy 1 (autosomal dominant)
OSM oncostatin M
P4HB prolyl 4-hydroxylase, beta polypeptide
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARL presenilin associated, rhomboid-like
PCGF2 polycomb group ring finger 2
PDCD5 programmed cell death 5
PDCD7 programmed cell death 7
PDIA2 protein disulfide isomerase family A, member 2
PDIA3 protein disulfide isomerase family A, member 3
PDILT protein disulfide isomerase-like, testis expressed
PDX1 pancreatic and duodenal homeobox 1
PEA15 phosphoprotein enriched in astrocytes 15
PELI3 pellino E3 ubiquitin protein ligase family member 3
PF4 platelet factor 4
PGAP2 post-GPI attachment to proteins 2
PHIP pleckstrin homology domain interacting protein
PIAS4 protein inhibitor of activated STAT, 4
PIDD1 p53-induced death domain protein 1
PINK1 PTEN induced putative kinase 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAGL2 pleiomorphic adenoma gene-like 2
PLAUR plasminogen activator, urokinase receptor
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
PPIF peptidylprolyl isomerase F
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRELID1 PRELI domain containing 1
PRKCD protein kinase C, delta
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PSEN1 presenilin 1
PSEN2 presenilin 2
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTEN phosphatase and tensin homolog
PYCARD PYD and CARD domain containing
RAD9A RAD9 homolog A (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1CC1 RB1-inducible coiled-coil 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RPS3 ribosomal protein S3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SCRT2 scratch family zinc finger 2
SEPT4 septin 4
SERINC3 serine incorporator 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SGMS1 sphingomyelin synthase 1
SH3RF1 SH3 domain containing ring finger 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIRT1 sirtuin 1
SKIL SKI-like proto-oncogene
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC35F6 solute carrier family 35, member F6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD3 SMAD family member 3
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SP100 SP100 nuclear antigen
SPOP speckle-type POZ protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
ST20 suppressor of tumorigenicity 20
STEAP3 STEAP family member 3, metalloreductase
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
STRADB STE20-related kinase adaptor beta
STX4 syntaxin 4
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFDP1 transcription factor Dp-1
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
THBS1 thrombospondin 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMC8 transmembrane channel-like 8
TMEM102 transmembrane protein 102
TMEM161A transmembrane protein 161A
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TPD52L1 tumor protein D52-like 1
TPT1 tumor protein, translationally-controlled 1
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TRAP1 TNF receptor-associated protein 1
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM32 tripartite motif containing 32
TRIM39 tripartite motif containing 39
TRPS1 trichorhinophalangeal syndrome I
UBB ubiquitin B
UBQLN1 ubiquilin 1
UNC5B unc-5 homolog B (C. elegans)
URI1 URI1, prefoldin-like chaperone
USP47 ubiquitin specific peptidase 47
VDAC2 voltage-dependent anion channel 2
VIMP VCP-interacting membrane selenoprotein
VNN1 vanin 1
WFS1 Wolfram syndrome 1 (wolframin)
WNT4 wingless-type MMTV integration site family, member 4
WWOX WW domain containing oxidoreductase
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
YBX3 Y box binding protein 3
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZC3HC1 zinc finger, C3HC-type containing 1
ZMYND11 zinc finger, MYND-type containing 11
ZNF205 zinc finger protein 205
ZNF385A zinc finger protein 385A
ZSWIM2 zinc finger, SWIM-type containing 2