reduced long term potentiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells (Mammalian Phenotype Ontology, MP_0001473)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001473
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Genes

103 gene mutations causing the reduced long term potentiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADD2 adducin 2 (beta)
AKAP5 A kinase (PRKA) anchor protein 5
APP amyloid beta (A4) precursor protein
ARC activity-regulated cytoskeleton-associated protein
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ATRX alpha thalassemia/mental retardation syndrome X-linked
ATXN1 ataxin 1
B3GAT1 beta-1,3-glucuronyltransferase 1
BDNF brain-derived neurotrophic factor
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNG8 calcium channel, voltage-dependent, gamma subunit 8
CALB2 calbindin 2
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHST10 carbohydrate sulfotransferase 10
CNGA2 cyclic nucleotide gated channel alpha 2
CPLX2 complexin 2
CREB1 cAMP responsive element binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYBB cytochrome b-245, beta polypeptide
DGKB diacylglycerol kinase, beta 90kDa
DGKE diacylglycerol kinase, epsilon 64kDa
DISC1 disrupted in schizophrenia 1
DOC2A double C2-like domains, alpha
DPYSL4 dihydropyrimidinase-like 4
EFNA3 ephrin-A3
EFNB3 ephrin-B3
EPHA4 EPH receptor A4
ESR2 estrogen receptor 2 (ER beta)
FMR1 fragile X mental retardation 1
FYN FYN proto-oncogene, Src family tyrosine kinase
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIK3 glutamate receptor, ionotropic, kainate 3
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRM1 glutamate receptor, metabotropic 1
GRM5 glutamate receptor, metabotropic 5
GRN granulin
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ITM2B integral membrane protein 2B
KALRN kalirin, RhoGEF kinase
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIF17 kinesin family member 17
KSR1 kinase suppressor of ras 1
LEPR leptin receptor
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAPK3 mitogen-activated protein kinase 3
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
MECP2 methyl CpG binding protein 2
MMP9 matrix metallopeptidase 9
NCF1 neutrophil cytosolic factor 1
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1
NRXN3 neurexin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPRM1 opioid receptor, mu 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PINK1 PTEN induced putative kinase 1
PLAT plasminogen activator, tissue
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKCG protein kinase C, gamma
PRNP prion protein
PSAP prosaposin
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RARB retinoic acid receptor, beta
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RAVER1 ribonucleoprotein, PTB-binding 1
RIMS1 regulating synaptic membrane exocytosis 1
SCT secretin
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHANK3 SH3 and multiple ankyrin repeat domains 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SP4 Sp4 transcription factor
SPRED1 sprouty-related, EVH1 domain containing 1
SRR serine racemase
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STX1A syntaxin 1A (brain)
SYNGAP1 synaptic Ras GTPase activating protein 1
SYNPO synaptopodin
THY1 Thy-1 cell surface antigen
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UBE3A ubiquitin protein ligase E3A
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VDAC1 voltage-dependent anion channel 1
VLDLR very low density lipoprotein receptor
WWC1 WW and C2 domain containing 1