recurrent infections Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Increased susceptibility to microbial infections, as manifested by recurrent episodes of infection. (Human Phenotype Ontology, HP_0002719)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0002719
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Genes

179 genes associated with the recurrent infections phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.38254
TLR1 toll-like receptor 1 0.709085
PRNP prion protein 0.693122
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.596067
CRHR1 corticotropin releasing hormone receptor 1 0.556558
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.553861
FAM114A1 family with sequence similarity 114, member A1 0.527751
TLR10 toll-like receptor 10 0.510576
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.48681
TLR6 toll-like receptor 6 0.432606
C2CD2 C2 calcium-dependent domain containing 2 0.406076
CSMD1 CUB and Sushi multiple domains 1 0.395205
ZFPM2 zinc finger protein, FOG family member 2 0.393481
CLU clusterin 0.38913
NPAS3 neuronal PAS domain protein 3 0.383461
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.38345
CD2AP CD2-associated protein 0.377528
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.372031
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.370053
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.364431
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.364421
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.361532
CHN2 chimerin 2 0.358719
IL2RB interleukin 2 receptor, beta 0.356732
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.345887
CCDC62 coiled-coil domain containing 62 0.345153
STXBP5 syntaxin binding protein 5 (tomosyn) 0.34437
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 0.338502
CDH13 cadherin 13 0.338502
DSCAM Down syndrome cell adhesion molecule 0.338502
ZBTB38 zinc finger and BTB domain containing 38 0.338502
PARD3B par-3 family cell polarity regulator beta 0.338502
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 0.33503
DUSP14 dual specificity phosphatase 14 0.33503
CSMD2 CUB and Sushi multiple domains 2 0.334889
ZNF229 zinc finger protein 229 0.332291
VWA8 von Willebrand factor A domain containing 8 0.330164
MYO1D myosin ID 0.329293
CHN1 chimerin 1 0.327418
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.326976
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.326976
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.324748
SPON1 spondin 1, extracellular matrix protein 0.324368
AHCYL2 adenosylhomocysteinase-like 2 0.324368
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.324122
FHIT fragile histidine triad 0.323588
PCSK6 proprotein convertase subtilisin/kexin type 6 0.322435
CD226 CD226 molecule 0.32144
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.319851
GFOD1 glucose-fructose oxidoreductase domain containing 1 0.319851
AKNAD1 AKNA domain containing 1 0.31906
ACBD6 acyl-CoA binding domain containing 6 0.318984
DNAH11 dynein, axonemal, heavy chain 11 0.318909
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.318612
MORC1 MORC family CW-type zinc finger 1 0.317567
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.3175
MYO5A myosin VA (heavy chain 12, myoxin) 0.317304
SLC12A9 solute carrier family 12, member 9 0.31724
SHISA6 shisa family member 6 0.317112
LRRC4C leucine rich repeat containing 4C 0.317048
OCA2 oculocutaneous albinism II 0.31686
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.316736
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 0.315909
MBTPS2 membrane-bound transcription factor peptidase, site 2 0.315683
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.315219
PTPRD protein tyrosine phosphatase, receptor type, D 0.313815
ANKMY2 ankyrin repeat and MYND domain containing 2 0.313575
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.313575
XYLT1 xylosyltransferase I 0.313457
NCKAP5 NCK-associated protein 5 0.313165
UBXN11 UBX domain protein 11 0.31305
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.312767
ANO2 anoctamin 2, calcium activated chloride channel 0.312767
HTT huntingtin 0.312381
SAMD4A sterile alpha motif domain containing 4A 0.312165
UBASH3B ubiquitin associated and SH3 domain containing B 0.311953
GRIK2 glutamate receptor, ionotropic, kainate 2 0.311336
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.310746
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.310227
PLS1 plastin 1 0.310089
DAGLA diacylglycerol lipase, alpha 0.309908
DZANK1 double zinc ribbon and ankyrin repeat domains 1 0.309818
RBL2 retinoblastoma-like 2 0.309248
ANO4 anoctamin 4 0.309162
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.308784
COL23A1 collagen, type XXIII, alpha 1 0.308743
COL12A1 collagen, type XII, alpha 1 0.308578
SDK1 sidekick cell adhesion molecule 1 0.308538
CPQ carboxypeptidase Q 0.308497
AKR1C3 aldo-keto reductase family 1, member C3 0.308497
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.308137
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 0.308058
UBA6 ubiquitin-like modifier activating enzyme 6 0.307408
ERBB4 erb-b2 receptor tyrosine kinase 4 0.307334
KLF12 Kruppel-like factor 12 0.307186
ARHGAP26 Rho GTPase activating protein 26 0.307149
NCK2 NCK adaptor protein 2 0.306824
GAS7 growth arrest-specific 7 0.306542
NXPH2 neurexophilin 2 0.306163
LEKR1 leucine, glutamate and lysine rich 1 0.306129
C17ORF99 chromosome 17 open reading frame 99 0.305631
MCHR2 melanin-concentrating hormone receptor 2 0.305026
REPS2 RALBP1 associated Eps domain containing 2 0.304182
VSTM2A V-set and transmembrane domain containing 2A 0.30398
SGMS1 sphingomyelin synthase 1 0.303894
SRPK1 SRSF protein kinase 1 0.303808
SOX6 SRY (sex determining region Y)-box 6 0.303696
TMEM51 transmembrane protein 51 0.303528
ZNF318 zinc finger protein 318 0.302721
C17ORF78 chromosome 17 open reading frame 78 0.302669
LARP6 La ribonucleoprotein domain family, member 6 0.302113
GRK5 G protein-coupled receptor kinase 5 0.301592
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.301176
LY86-AS1 LY86 antisense RNA 1 0.300914
LHFPL5 lipoma HMGIC fusion partner-like 5 0.300885
RBMS3 RNA binding motif, single stranded interacting protein 3 0.300656
IGSF21 immunoglobin superfamily, member 21 0.300458
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 0.300346
IL18R1 interleukin 18 receptor 1 0.299504
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 0.29932
WIPF3 WAS/WASL interacting protein family, member 3 0.299138
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.298805
ZNF415 zinc finger protein 415 0.298755
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.298554
ULK4 unc-51 like kinase 4 0.298381
ITPKB inositol-trisphosphate 3-kinase B 0.29816
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 0.298136
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.298087
LRP1B low density lipoprotein receptor-related protein 1B 0.297681
SEC13 SEC13 homolog (S. cerevisiae) 0.297517
SCHIP1 schwannomin interacting protein 1 0.29717
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 0.29717
GEMIN7 gem (nuclear organelle) associated protein 7 0.296787
SCD5 stearoyl-CoA desaturase 5 0.2965
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 0.296434
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.29639
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 0.295772
MRRF mitochondrial ribosome recycling factor 0.29542
PALM2 paralemmin 2 0.295339
RBM11 RNA binding motif protein 11 0.29441
SLIT3 slit homolog 3 (Drosophila) 0.294295
HIP1 huntingtin interacting protein 1 0.294257
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.293919
PROM1 prominin 1 0.293789
SQRDL sulfide quinone reductase-like (yeast) 0.293661
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.293388
DNAH8 dynein, axonemal, heavy chain 8 0.293299
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.292823
CECR1 cat eye syndrome chromosome region, candidate 1 0.292634
TESPA1 thymocyte expressed, positive selection associated 1 0.292328
SCAI suppressor of cancer cell invasion 0.292111
NRXN3 neurexin 3 0.290716
CCDC148 coiled-coil domain containing 148 0.290716
LHFP lipoma HMGIC fusion partner 0.289975
MAPK4 mitogen-activated protein kinase 4 0.289268
ANO3 anoctamin 3 0.288994
IPCEF1 interaction protein for cytohesin exchange factors 1 0.288859
IL1RAP interleukin 1 receptor accessory protein 0.288071
SLIT1 slit homolog 1 (Drosophila) 0.287322
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 0.286817
KIF20B kinesin family member 20B 0.282321
SCGB1D2 secretoglobin, family 1D, member 2 0.281668
CORIN corin, serine peptidase 0.281561
KLHL7 kelch-like family member 7 0.281246
MVK mevalonate kinase 0.281038
KIAA0226 KIAA0226 0.280429
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.280329
ITFG1 integrin alpha FG-GAP repeat containing 1 0.280329
PANK1 pantothenate kinase 1 0.279269
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.279083
SETBP1 SET binding protein 1 0.279083
ADAM22 ADAM metallopeptidase domain 22 0.278356
GP6 glycoprotein VI (platelet) 0.278091
ROPN1 rhophilin associated tail protein 1 0.277743
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.277658
LRP2 low density lipoprotein receptor-related protein 2 0.272228
RANBP3L RAN binding protein 3-like 0.267145
ERP44 endoplasmic reticulum protein 44 0.263453
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 0.250712