recurrent bacterial infections Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description Increased susceptibility to bacterial infections, as manifested by recurrent episodes of bacterial infection. (Human Phenotype Ontology, HP_0002718)
External Link http://compbio.charite.de/hpoweb/showterm?id=HP:0002718
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Genes

71 genes associated with the recurrent bacterial infections phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
ADA adenosine deaminase
AICDA activation-induced cytidine deaminase
AP3B1 adaptor-related protein complex 3, beta 1 subunit
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C6 complement component 6
C7 complement component 7
C8B complement component 8, beta polypeptide
CD19 CD19 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CD8A CD8a molecule
CFD complement factor D (adipsin)
CFH complement factor H
CFI complement factor I
CIITA class II, major histocompatibility complex, transactivator
CTSC cathepsin C
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
DCLRE1C DNA cross-link repair 1C
DOCK8 dedicator of cytokinesis 8
ELANE elastase, neutrophil expressed
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
FERMT3 fermitin family member 3
G6PC3 glucose 6 phosphatase, catalytic, 3
GATA2 GATA binding protein 2
GJB2 gap junction protein, beta 2, 26kDa
HAX1 HCLS1 associated protein X-1
ICOS inducible T-cell co-stimulator
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10RA interleukin 10 receptor, alpha
IL2RA interleukin 2 receptor, alpha
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAGN1 jagunal homolog 1 (Drosophila)
LYST lysosomal trafficking regulator
MALT1 MALT1 paracaspase
MAN2B1 mannosidase, alpha, class 2B, member 1
MNX1 motor neuron and pancreas homeobox 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNP purine nucleoside phosphorylase
PSEN1 presenilin 1
PSENEN presenilin enhancer gamma secretase subunit
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
RAB27A RAB27A, member RAS oncogene family
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RFXANK regulatory factor X-associated ankyrin-containing protein
RFXAP regulatory factor X-associated protein
RPGR retinitis pigmentosa GTPase regulator
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIM1 stromal interaction molecule 1
STK4 serine/threonine kinase 4
TBCE tubulin folding cofactor E
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TYK2 tyrosine kinase 2
UNG uracil-DNA glycosylase
WAS Wiskott-Aldrich syndrome