reading disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A learning disability involing difficulty reading resulting primarily from neurological factors which affect any part of the reading process. (Human Disease Ontology, DOID_13365)
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Genes

147 genes co-occuring with the disease reading disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
DYX1C1 dyslexia susceptibility 1 candidate 1 3.28299
KIAA0319 KIAA0319 3.24142
DCDC2 doublecortin domain containing 2 3.10979
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 2.15354
MRPL19 mitochondrial ribosomal protein L19 2.07396
GCFC2 GC-rich sequence DNA-binding factor 2 2.06261
KIAA0319L KIAA0319-like 1.9769
TDP2 tyrosyl-DNA phosphodiesterase 2 1.67729
ZNF280D zinc finger protein 280D 1.64621
DOCK4 dedicator of cytokinesis 4 1.51984
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 1.47418
ARL17A ADP-ribosylation factor-like 17A 1.45836
ARL17B ADP-ribosylation factor-like 17B 1.45836
TMEM257 transmembrane protein 257 1.45836
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 1.3952
FMR1NB fragile X mental retardation 1 neighbor 1.30882
KAAG1 kidney associated antigen 1 1.30576
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 1.2909
ACOT13 acyl-CoA thioesterase 13 1.27344
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 1.23256
DCDC5 doublecortin domain containing 5 1.22865
CNTNAP2 contactin associated protein-like 2 1.22822
FOXP2 forkhead box P2 1.22475
PLA2G4B phospholipase A2, group IVB (cytosolic) 1.16863
FMR1-AS1 FMR1 antisense RNA 1 1.1524
CMIP c-Maf inducing protein 1.12994
NTAN1 N-terminal asparagine amidase 1.08999
LRRC37A3 leucine rich repeat containing 37, member A3 1.08747
LRRC37A leucine rich repeat containing 37A 1.08747
CNTNAP5 contactin associated protein-like 5 1.0837
SLITRK2 SLIT and NTRK-like family, member 2 1.08076
NEGR1 neuronal growth regulator 1 1.06018
DCX doublecortin 1.05009
PAPOLG poly(A) polymerase gamma 1.04462
NODAL nodal growth differentiation factor 1.03325
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 0.984321
NEUROD6 neuronal differentiation 6 0.981794
TMOD2 tropomodulin 2 (neuronal) 0.97338
DGKI diacylglycerol kinase, iota 0.956196
CXXC5 CXXC finger protein 5 0.949936
KANSL1 KAT8 regulatory NSL complex subunit 1 0.942443
GTF2I general transcription factor IIi 0.876966
DRD4 dopamine receptor D4 0.873281
LRRTM1 leucine rich repeat transmembrane neuronal 1 0.861818
TCF12 transcription factor 12 0.858543
TMOD3 tropomodulin 3 (ubiquitous) 0.842982
MYO18B myosin XVIIIB 0.833558
PCSK6 proprotein convertase subtilisin/kexin type 6 0.817565
PLCB2 phospholipase C, beta 2 0.796642
DRD5 dopamine receptor D5 0.789672
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 0.767167
TMOD4 tropomodulin 4 (muscle) 0.762678
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.757786
MYO5B myosin VB 0.756564
ADGRL3 adhesion G protein-coupled receptor L3 0.753306
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.746391
A1CF APOBEC1 complementation factor 0.727333
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.719654
PDE7B phosphodiesterase 7B 0.713601
TK2 thymidine kinase 2, mitochondrial 0.695905
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 0.693098
MC5R melanocortin 5 receptor 0.687491
MED12 mediator complex subunit 12 0.670333
DLX1 distal-less homeobox 1 0.666755
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.66596
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 0.665563
DYM dymeclin 0.660404
NCOA2 nuclear receptor coactivator 2 0.648533
PXDN peroxidasin 0.647743
MSI2 musashi RNA-binding protein 2 0.646165
RAP2A RAP2A, member of RAS oncogene family 0.635135
OTX1 orthodenticle homeobox 1 0.633169
AUTS2 autism susceptibility candidate 2 0.624143
PRMT2 protein arginine methyltransferase 2 0.606543
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.60108
IMPACT impact RWD domain protein 0.590948
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.588222
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.585887
NDE1 nudE neurodevelopment protein 1 0.575383
ASIC2 acid sensing (proton gated) ion channel 2 0.566831
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 0.559062
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.544705
BHLHE41 basic helix-loop-helix family, member e41 0.528449
TIMELESS timeless circadian clock 0.52729
DRD3 dopamine receptor D3 0.514571
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.510728
BHLHE40 basic helix-loop-helix family, member e40 0.50689
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.505356
FTCD formimidoyltransferase cyclodeaminase 0.501909
APOPT1 apoptogenic 1, mitochondrial 0.501144
KIF3A kinesin family member 3A 0.495793
ZNF804A zinc finger protein 804A 0.49274
PCDH11X protocadherin 11 X-linked 0.485505
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.484744
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.476014
SPTBN1 spectrin, beta, non-erythrocytic 1 0.475634
METTL13 methyltransferase like 13 0.474119
ICT1 immature colon carcinoma transcript 1 0.449194
LSR lipolysis stimulated lipoprotein receptor 0.446182
ADD2 adducin 2 (beta) 0.445429
DCLK1 doublecortin-like kinase 1 0.44129
PCNT pericentrin 0.427015
NRP2 neuropilin 2 0.424014
MYRF myelin regulatory factor 0.418768
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.39598
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 0.386308
NRGN neurogranin (protein kinase C substrate, RC3) 0.379256
UBIAD1 UbiA prenyltransferase domain containing 1 0.373328
ADRA2A adrenoceptor alpha 2A 0.371477
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.368888
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.368518
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.364454
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.362239
EEA1 early endosome antigen 1 0.360026
GABARAP GABA(A) receptor-associated protein 0.358551
MCPH1 microcephalin 1 0.354499
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.33651
PHB2 prohibitin 2 0.333583
LPP LIM domain containing preferred translocation partner in lipoma 0.311377
S100B S100 calcium binding protein B 0.308118
DSC3 desmocollin 3 0.300533
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.289744
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.287235
FLNA filamin A, alpha 0.286519
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.284728
TCF4 transcription factor 4 0.279011
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 0.263014
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.256652
SNRPN small nuclear ribonucleoprotein polypeptide N 0.252774
GK glycerol kinase 0.250663
PROX1 prospero homeobox 1 0.24996
CALB2 calbindin 2 0.247501
RTN4R reticulon 4 receptor 0.245396
DRD2 dopamine receptor D2 0.221793
RRM2 ribonucleotide reductase M2 0.218374
FMR1 fragile X mental retardation 1 0.208579
CTTN cortactin 0.208245
RHCE Rh blood group, CcEe antigens 0.205916
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.204923
MOG myelin oligodendrocyte glycoprotein 0.189551
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.189244
TCN2 transcobalamin II 0.179239
SPTB spectrin, beta, erythrocytic 0.178682
INA internexin neuronal intermediate filament protein, alpha 0.177029
NF1 neurofibromin 1 0.175679
KAT5 K(lysine) acetyltransferase 5 0.170299
AFF2 AF4/FMR2 family, member 2 0.169571