ramifenazone-7233 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ramifenazone-7233 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACTN2 actinin, alpha 2
ADAM8 ADAM metallopeptidase domain 8
AKR1C2 aldo-keto reductase family 1, member C2
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATAT1 alpha tubulin acetyltransferase 1
C17ORF59 chromosome 17 open reading frame 59
C8ORF60 chromosome 8 open reading frame 60
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD82 CD82 molecule
CDRT1 CMT1A duplicated region transcript 1
CLCA2 chloride channel accessory 2
CNOT3 CCR4-NOT transcription complex, subunit 3
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DLK2 delta-like 2 homolog (Drosophila)
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
ELL2 elongation factor, RNA polymerase II, 2
ELOVL5 ELOVL fatty acid elongase 5
ELP6 elongator acetyltransferase complex subunit 6
EML3 echinoderm microtubule associated protein like 3
ESR1 estrogen receptor 1
FAM13C family with sequence similarity 13, member C
FAM186A family with sequence similarity 186, member A
FKBP10 FK506 binding protein 10, 65 kDa
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GJA9 gap junction protein, alpha 9, 59kDa
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GSK3A glycogen synthase kinase 3 alpha
HBS1L HBS1-like translational GTPase
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HNF1A HNF1 homeobox A
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INCENP inner centromere protein antigens 135/155kDa
INTS1 integrator complex subunit 1
ITGB6 integrin, beta 6
JAM3 junctional adhesion molecule 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KIAA0368 KIAA0368
LAT2 linker for activation of T cells family, member 2
LEPR leptin receptor
LRRC6 leucine rich repeat containing 6
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAN2A2 mannosidase, alpha, class 2A, member 2
MINK1 misshapen-like kinase 1
MMP25 matrix metallopeptidase 25
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK myosin light chain kinase
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OR7A10 olfactory receptor, family 7, subfamily A, member 10
OTUD4 OTU deubiquitinase 4
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEX5 peroxisomal biogenesis factor 5
PLLP plasmolipin
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PSD4 pleckstrin and Sec7 domain containing 4
PSG4 pregnancy specific beta-1-glycoprotein 4
PXDC1 PX domain containing 1
RAB3B RAB3B, member RAS oncogene family
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RPL18 ribosomal protein L18
RUFY3 RUN and FYVE domain containing 3
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SERHL2 serine hydrolase-like 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SSX1 synovial sarcoma, X breakpoint 1
SYCP1 synaptonemal complex protein 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAOK1 TAO kinase 1
TDRKH tudor and KH domain containing
TM4SF1 transmembrane 4 L six family member 1
TMEM120B transmembrane protein 120B
TMEM19 transmembrane protein 19
TMPRSS2 transmembrane protease, serine 2
TOP3A topoisomerase (DNA) III alpha
TPK1 thiamin pyrophosphokinase 1
TPP1 tripeptidyl peptidase I
TSPAN1 tetraspanin 1
UBA6 ubiquitin-like modifier activating enzyme 6
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR55 WD repeat domain 55
ZBTB33 zinc finger and BTB domain containing 33
ZER1 zyg-11 related, cell cycle regulator
ZNF41 zinc finger protein 41

decreased expression

Symbol Name
ANXA2P3 annexin A2 pseudogene 3
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
C22ORF29 chromosome 22 open reading frame 29
CCDC25 coiled-coil domain containing 25
CD302 CD302 molecule
CDON cell adhesion associated, oncogene regulated
CGREF1 cell growth regulator with EF-hand domain 1
CIC capicua transcriptional repressor
CISH cytokine inducible SH2-containing protein
CLEC16A C-type lectin domain family 16, member A
CLSPN claspin
CPOX coproporphyrinogen oxidase
CRYBG3 beta-gamma crystallin domain containing 3
CTSK cathepsin K
DSCAM Down syndrome cell adhesion molecule
DUSP2 dual specificity phosphatase 2
DUSP8 dual specificity phosphatase 8
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EXD3 exonuclease 3'-5' domain containing 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM155B family with sequence similarity 155, member B
FAM169A family with sequence similarity 169, member A
FBXO2 F-box protein 2
FLCN folliculin
FZD4 frizzled class receptor 4
GALK1 galactokinase 1
GAREM GRB2 associated, regulator of MAPK1
GID4 GID complex subunit 4
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPATCH2L G patch domain containing 2-like
GPX2 glutathione peroxidase 2
GRB7 growth factor receptor-bound protein 7
GUSBP3 glucuronidase, beta pseudogene 3
H2AFJ H2A histone family, member J
IFNA14 interferon, alpha 14
IL15RA interleukin 15 receptor, alpha
IPO8 importin 8
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF6 interferon regulatory factor 6
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
LNPEP leucyl/cystinyl aminopeptidase
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAST3 microtubule associated serine/threonine kinase 3
MBTD1 mbt domain containing 1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTMR11 myotubularin related protein 11
NUP62CL nucleoporin 62kDa C-terminal like
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHGB5 protocadherin gamma subfamily B, 5
PGP phosphoglycolate phosphatase
PGPEP1 pyroglutamyl-peptidase I
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
QTRT1 queuine tRNA-ribosyltransferase 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
RNF2 ring finger protein 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL23AP32 ribosomal protein L23a pseudogene 32
RPUSD2 RNA pseudouridylate synthase domain containing 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH2D4A SH2 domain containing 4A
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMA4 glucuronidase, beta pseudogene
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPIDR scaffolding protein involved in DNA repair
SPRYD7 SPRY domain containing 7
STARD3 StAR-related lipid transfer (START) domain containing 3
SYCP2 synaptonemal complex protein 2
TBX19 T-box 19
TCTN1 tectonic family member 1
TDRD1 tudor domain containing 1
TESK1 testis-specific kinase 1
THBS3 thrombospondin 3
TRAF2 TNF receptor-associated factor 2
TRIM5 tripartite motif containing 5
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
WDR4 WD repeat domain 4
WDR62 WD repeat domain 62
WLS wntless Wnt ligand secretion mediator
ZBED1 zinc finger, BED-type containing 1
ZFYVE16 zinc finger, FYVE domain containing 16
ZMAT5 zinc finger, matrin-type 5
ZNF141 zinc finger protein 141
ZNF212 zinc finger protein 212
ZNF492 zinc finger protein 492
ZNF675 zinc finger protein 675