raloxifene-6235 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the raloxifene-6235 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY6 adenylate cyclase 6
AKR1C1 aldo-keto reductase family 1, member C1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ATM ATM serine/threonine kinase
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAX BCL2-associated X protein
BTG2 BTG family, member 2
C22ORF46 chromosome 22 open reading frame 46
CCNO cyclin O
CD8B CD8b molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CHKB choline kinase beta
CORO7 coronin 7
CRYBG3 beta-gamma crystallin domain containing 3
CTSF cathepsin F
DDIT4 DNA-damage-inducible transcript 4
DOCK5 dedicator of cytokinesis 5
ECE1 endothelin converting enzyme 1
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
FAAH fatty acid amide hydrolase
FAM188A family with sequence similarity 188, member A
FLCN folliculin
FOXN2 forkhead box N2
GRM8 glutamate receptor, metabotropic 8
GUSBP3 glucuronidase, beta pseudogene 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HOXA6 homeobox A6
IBSP integrin-binding sialoprotein
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
ITPKB inositol-trisphosphate 3-kinase B
JRK Jrk homolog (mouse)
JUND jun D proto-oncogene
KDM8 lysine (K)-specific demethylase 8
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT19P2 keratin 19 pseudogene 2
LPIN1 lipin 1
LRRC14 leucine rich repeat containing 14
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP1B microtubule-associated protein 1B
MARK4 MAP/microtubule affinity-regulating kinase 4
MID1 midline 1
MMP19 matrix metallopeptidase 19
MPPE1 metallophosphoesterase 1
MSR1 macrophage scavenger receptor 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD4 MAX dimerization protein 4
N4BP1 NEDD4 binding protein 1
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OTUD3 OTU deubiquitinase 3
OVOL1 ovo-like zinc finger 1
PCDH11Y protocadherin 11 Y-linked
PCGF2 polycomb group ring finger 2
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PILRA paired immunoglobin-like type 2 receptor alpha
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCH1 phospholipase C, eta 1
PPP5C protein phosphatase 5, catalytic subunit
PRR4 proline rich 4 (lacrimal)
PTRF polymerase I and transcript release factor
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIMS2 regulating synaptic membrane exocytosis 2
RNF24 ring finger protein 24
RNF39 ring finger protein 39
RPS3A ribosomal protein S3A
SAMD4A sterile alpha motif domain containing 4A
SAMD9 sterile alpha motif domain containing 9
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SIK2 salt-inducible kinase 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOS2 son of sevenless homolog 2 (Drosophila)
SP100 SP100 nuclear antigen
SPAG8 sperm associated antigen 8
SUGP1 SURP and G patch domain containing 1
SYNJ2 synaptojanin 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMELESS timeless circadian clock
TK2 thymidine kinase 2, mitochondrial
TMEM63A transmembrane protein 63A
TRIM62 tripartite motif containing 62
TTLL5 tubulin tyrosine ligase-like family member 5
UBE3A ubiquitin protein ligase E3A
UBTD1 ubiquitin domain containing 1
UBXN1 UBX domain protein 1
ULBP2 UL16 binding protein 2
WDR1 WD repeat domain 1
WNT10B wingless-type MMTV integration site family, member 10B
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ADAM15 ADAM metallopeptidase domain 15
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASB9 ankyrin repeat and SOCS box containing 9
AXIN1 axin 1
C10ORF2 chromosome 10 open reading frame 2
C1ORF35 chromosome 1 open reading frame 35
C2CD2 C2 calcium-dependent domain containing 2
C9ORF40 chromosome 9 open reading frame 40
CCND1 cyclin D1
CISH cytokine inducible SH2-containing protein
COCH cochlin
CRCP CGRP receptor component
CTNNBL1 catenin, beta like 1
CXCL12 chemokine (C-X-C motif) ligand 12
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DNM1 dynamin 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ECHDC3 enoyl CoA hydratase domain containing 3
EGR3 early growth response 3
EVPL envoplakin
EXOC5 exocyst complex component 5
EYA2 EYA transcriptional coactivator and phosphatase 2
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FPGS folylpolyglutamate synthase
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GDAP1 ganglioside induced differentiation associated protein 1
GJA1 gap junction protein, alpha 1, 43kDa
GMEB1 glucocorticoid modulatory element binding protein 1
GSTT1 glutathione S-transferase theta 1
GTF2I general transcription factor IIi
H2AFY2 H2A histone family, member Y2
HPS6 Hermansky-Pudlak syndrome 6
HPSE heparanase
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGFBP4 insulin-like growth factor binding protein 4
IL17RB interleukin 17 receptor B
INO80D INO80 complex subunit D
ISG15 ISG15 ubiquitin-like modifier
KIAA0020 KIAA0020
KLF10 Kruppel-like factor 10
KLHL21 kelch-like family member 21
KRT13 keratin 13, type I
LYPLA2P1 lysophospholipase II pseudogene 1
LZTR1 leucine-zipper-like transcription regulator 1
MANEA mannosidase, endo-alpha
MED9 mediator complex subunit 9
METTL1 methyltransferase like 1
MOCS2 molybdenum cofactor synthesis 2
MORC3 MORC family CW-type zinc finger 3
MPPED2 metallophosphoesterase domain containing 2
MREG melanoregulin
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MXD3 MAX dimerization protein 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
NR1D2 nuclear receptor subfamily 1, group D, member 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDZK1 PDZ domain containing 1
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRR7 proline rich 7 (synaptic)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RECQL4 RecQ protein-like 4
REEP4 receptor accessory protein 4
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RIPPLY3 ripply transcriptional repressor 3
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF31 ring finger protein 31
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAV1 salvador family WW domain containing protein 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC22A18 solute carrier family 22, member 18
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SMYD5 SMYD family member 5
STC2 stanniocalcin 2
SULF1 sulfatase 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN1 tectonic family member 1
TGDS TDP-glucose 4,6-dehydratase
TMC7 transmembrane channel-like 7
TMEM164 transmembrane protein 164
TTLL12 tubulin tyrosine ligase-like family member 12
UBXN6 UBX domain protein 6
XYLT2 xylosyltransferase II
ZNF276 zinc finger protein 276
ZNF586 zinc finger protein 586
ZNF668 zinc finger protein 668
ZNF787 zinc finger protein 787
ZNF816 zinc finger protein 816
ZNF83 zinc finger protein 83
ZNHIT2 zinc finger, HIT-type containing 2