pyrvinium-978 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the pyrvinium-978 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADM adrenomedullin
AKR1D1 aldo-keto reductase family 1, member D1
AMOTL2 angiomotin like 2
AMPD1 adenosine monophosphate deaminase 1
ANXA1 annexin A1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPIN actin-related protein 2/3 complex inhibitor
ATF3 activating transcription factor 3
BBC3 BCL2 binding component 3
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK12 cyclin-dependent kinase 12
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CTTN cortactin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIAPH1 diaphanous-related formin 1
DMPK dystrophia myotonica-protein kinase
E2F4 E2F transcription factor 4, p107/p130-binding
EGR1 early growth response 1
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FURIN furin (paired basic amino acid cleaving enzyme)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GPR87 G protein-coupled receptor 87
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HDAC11 histone deacetylase 11
ICAM1 intercellular adhesion molecule 1
IL17RA interleukin 17 receptor A
INHBE inhibin, beta E
JUND jun D proto-oncogene
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LIF leukemia inhibitory factor
LPIN1 lipin 1
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1S microtubule-associated protein 1S
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMRN2 multimerin 2
MTRF1L mitochondrial translational release factor 1-like
N4BP2L2 NEDD4 binding protein 2-like 2
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH1 notch 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PCDH1 protocadherin 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB32 RAB32, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RNF19B ring finger protein 19B
RPL5 ribosomal protein L5
SAMD4A sterile alpha motif domain containing 4A
SESN1 sestrin 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMAD3 SMAD family member 3
SOX13 SRY (sex determining region Y)-box 13
SPINK5 serine peptidase inhibitor, Kazal type 5
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TES testin LIM domain protein
TFE3 transcription factor binding to IGHM enhancer 3
TGFB2 transforming growth factor, beta 2
TLR2 toll-like receptor 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNK1 tyrosine kinase, non-receptor, 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
ZNF205 zinc finger protein 205
ZNF580 zinc finger protein 580
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ACKR3 atypical chemokine receptor 3
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AKAP12 A kinase (PRKA) anchor protein 12
AMD1 adenosylmethionine decarboxylase 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARMCX1 armadillo repeat containing, X-linked 1
ASF1B anti-silencing function 1B histone chaperone
ASPHD1 aspartate beta-hydroxylase domain containing 1
ASTE1 asteroid homolog 1 (Drosophila)
ATAD5 ATPase family, AAA domain containing 5
ATP7B ATPase, Cu++ transporting, beta polypeptide
B3GNT1
BMP4 bone morphogenetic protein 4
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C9ORF40 chromosome 9 open reading frame 40
CA2 carbonic anhydrase II
CCDC15 coiled-coil domain containing 15
CCNE1 cyclin E1
CCNE2 cyclin E2
CDC6 cell division cycle 6
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CNPY3 canopy FGF signaling regulator 3
COL4A5 collagen, type IV, alpha 5
CTSV cathepsin V
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DHRS11 dehydrogenase/reductase (SDR family) member 11
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EFCAB2 EF-hand calcium binding domain 2
EFHD2 EF-hand domain family, member D2
EGLN3 egl-9 family hypoxia-inducible factor 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPM2AIP1 EPM2A (laforin) interacting protein 1
ERCC6L excision repair cross-complementation group 6-like
FAM50B family with sequence similarity 50, member B
FAM63A family with sequence similarity 63, member A
FPGT fucose-1-phosphate guanylyltransferase
GJA1 gap junction protein, alpha 1, 43kDa
GPR19 G protein-coupled receptor 19
GRWD1 glutamate-rich WD repeat containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H3G histone cluster 1, H3g
HMGB3P1 high mobility group box 3 pseudogene 1
IGFLR1 IGF-like family receptor 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IPP intracisternal A particle-promoted polypeptide
KIFC1 kinesin family member C1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMNB1 lamin B1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAGEH1 melanoma antigen family H1
MCM10 minichromosome maintenance complex component 10
MDM1 Mdm1 nuclear protein homolog (mouse)
METTL2B methyltransferase like 2B
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOSPD3 motile sperm domain containing 3
MRPL17 mitochondrial ribosomal protein L17
NAP1L2 nucleosome assembly protein 1-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBEAL2 neurobeachin-like 2
NCS1 neuronal calcium sensor 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKAIN1 Na+/K+ transporting ATPase interacting 1
NME6 NME/NM23 nucleoside diphosphate kinase 6
ORC1 origin recognition complex, subunit 1
PARD6A par-6 family cell polarity regulator alpha
PCF11 PCF11 cleavage and polyadenylation factor subunit
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMP22 peripheral myelin protein 22
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR15L proline rich 15-like
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
PYCRL pyrroline-5-carboxylate reductase-like
RAB8B RAB8B, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RANBP6 RAN binding protein 6
RARS arginyl-tRNA synthetase
RPA2 replication protein A2, 32kDa
SMCO4 single-pass membrane protein with coiled-coil domains 4
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TBCC tubulin folding cofactor C
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TOE1 target of EGR1, member 1 (nuclear)
TPST2 tyrosylprotein sulfotransferase 2
TRAM2 translocation associated membrane protein 2
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VANGL1 VANGL planar cell polarity protein 1
ZNF778 zinc finger protein 778
ZNF813 zinc finger protein 813