pyrithyldione-2740 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the pyrithyldione-2740 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ADRA1A adrenoceptor alpha 1A
AQP1 aquaporin 1 (Colton blood group)
ATXN3 ataxin 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP8A bone morphogenetic protein 8a
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF1 chromosome 14 open reading frame 1
C14ORF105 chromosome 14 open reading frame 105
C8A complement component 8, alpha polypeptide
CALD1 caldesmon 1
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC92 coiled-coil domain containing 92
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CKM creatine kinase, muscle
CLDN3 claudin 3
CSHL1 chorionic somatomammotropin hormone-like 1
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
EBF2 early B-cell factor 2
FAM13C family with sequence similarity 13, member C
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLJ11292
FOXA2 forkhead box A2
FOXL1 forkhead box L1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GRIK2 glutamate receptor, ionotropic, kainate 2
GRK4 G protein-coupled receptor kinase 4
GRM1 glutamate receptor, metabotropic 1
GSTA3 glutathione S-transferase alpha 3
HAMP hepcidin antimicrobial peptide
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BN histone cluster 1, H2bn
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXB3 homeobox B3
HPR haptoglobin-related protein
IL1R1 interleukin 1 receptor, type I
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL1RN interleukin 1 receptor antagonist
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KLHL22 kelch-like family member 22
KRT81 keratin 81, type II
KSR1 kinase suppressor of ras 1
LBX1 ladybird homeobox 1
LMF1 lipase maturation factor 1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MRAS muscle RAS oncogene homolog
MRPS18C mitochondrial ribosomal protein S18C
MYO6 myosin VI
NAG18 NAG18 mRNA
NLGN1 neuroligin 1
NRG1 neuregulin 1
PADI4 peptidyl arginine deiminase, type IV
PAX8 paired box 8
PBOV1 prostate and breast cancer overexpressed 1
PCDHB17P protocadherin beta 17 pseudogene
PDX1 pancreatic and duodenal homeobox 1
PICALM phosphatidylinositol binding clathrin assembly protein
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PIP prolactin-induced protein
PLCH1 phospholipase C, eta 1
PMP2 peripheral myelin protein 2
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRB1 proline-rich protein BstNI subfamily 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBPMS RNA binding protein with multiple splicing
RGS6 regulator of G-protein signaling 6
SCN11A sodium channel, voltage gated, type XI alpha subunit
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH3D21 SH3 domain containing 21
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMR3B submaxillary gland androgen regulated protein 3B
SPAG8 sperm associated antigen 8
SPRR1A small proline-rich protein 1A
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SSX1 synovial sarcoma, X breakpoint 1
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STATH statherin
TAL1 T-cell acute lymphocytic leukemia 1
TJP3 tight junction protein 3
TMEM212 transmembrane protein 212
TRIO trio Rho guanine nucleotide exchange factor
ZNF415 zinc finger protein 415
ZNF44 zinc finger protein 44
ZNF440 zinc finger protein 440
ZNF471 zinc finger protein 471

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARG1 arginase 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BOLA1 bolA family member 1
CCDC57 coiled-coil domain containing 57
CCDC9 coiled-coil domain containing 9
CD300C CD300c molecule
CD37 CD37 molecule
CES3 carboxylesterase 3
CLCN5 chloride channel, voltage-sensitive 5
CLDN15 claudin 15
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CRELD1 cysteine-rich with EGF-like domains 1
CXORF56 chromosome X open reading frame 56
DCAF13 DDB1 and CUL4 associated factor 13
DENND5B DENN/MADD domain containing 5B
DGKG diacylglycerol kinase, gamma 90kDa
DKK2 dickkopf WNT signaling pathway inhibitor 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EFNA3 ephrin-A3
EFNA4 ephrin-A4
EGR3 early growth response 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
F13A1 coagulation factor XIII, A1 polypeptide
FKBP9 FK506 binding protein 9, 63 kDa
GID4 GID complex subunit 4
GK3P glycerol kinase 3 pseudogene
GNL1 guanine nucleotide binding protein-like 1
GRAMD1B GRAM domain containing 1B
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HHLA3 HERV-H LTR-associating 3
HIST1H2BH histone cluster 1, H2bh
HOXC8 homeobox C8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INCENP inner centromere protein antigens 135/155kDa
INF2 inverted formin, FH2 and WH2 domain containing
KATNBL1 katanin p80 subunit B-like 1
KIAA0319L KIAA0319-like
KIAA1107 KIAA1107
LRP5 low density lipoprotein receptor-related protein 5
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP3 latent transforming growth factor beta binding protein 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEH1 melanoma antigen family H1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
NCS1 neuronal calcium sensor 1
NFE2L3 nuclear factor, erythroid 2-like 3
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLAH oleoyl-ACP hydrolase
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PADI2 peptidyl arginine deiminase, type II
PGAP1 post-GPI attachment to proteins 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLD3 phospholipase D family, member 3
PORCN porcupine homolog (Drosophila)
PRDM1 PR domain containing 1, with ZNF domain
PRICKLE3 prickle homolog 3 (Drosophila)
RAB3A RAB3A, member RAS oncogene family
RHBDD3 rhomboid domain containing 3
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNF122 ring finger protein 122
SCG5 secretogranin V
SCN10A sodium channel, voltage gated, type X alpha subunit
SERINC5 serine incorporator 5
SGMS1 sphingomyelin synthase 1
SH2D4A SH2 domain containing 4A
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPAG1 sperm associated antigen 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STBD1 starch binding domain 1
SYCP2 synaptonemal complex protein 2
TM7SF3 transmembrane 7 superfamily member 3
TMEM242 transmembrane protein 242
TMEM53 transmembrane protein 53
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM3 tropomyosin 3
TRIM25 tripartite motif containing 25
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPS1 trichorhinophalangeal syndrome I
TSC22D4 TSC22 domain family, member 4
UNC13B unc-13 homolog B (C. elegans)
UPB1 ureidopropionase, beta
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZBTB25 zinc finger and BTB domain containing 25
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF155 zinc finger protein 155
ZNF16 zinc finger protein 16
ZNF177 zinc finger protein 177
ZNF215 zinc finger protein 215
ZNF225 zinc finger protein 225
ZNF34 zinc finger protein 34
ZNF492 zinc finger protein 492
ZNF528 zinc finger protein 528