pyrimethamine-4779 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the pyrimethamine-4779 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ADAM10 ADAM metallopeptidase domain 10
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARL4C ADP-ribosylation factor-like 4C
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C19ORF66 chromosome 19 open reading frame 66
CDC14A cell division cycle 14A
CDK12 cyclin-dependent kinase 12
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHML choroideremia-like (Rab escort protein 2)
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLDND1 claudin domain containing 1
COCH cochlin
COL9A3 collagen, type IX, alpha 3
CTNS cystinosin, lysosomal cystine transporter
CXCL8 chemokine (C-X-C motif) ligand 8
DCAF4 DDB1 and CUL4 associated factor 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DENND4A DENN/MADD domain containing 4A
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP13 dual specificity phosphatase 13
EED embryonic ectoderm development
EFNA3 ephrin-A3
EGR3 early growth response 3
ERAP1 endoplasmic reticulum aminopeptidase 1
ETAA1 Ewing tumor-associated antigen 1
EXOC5 exocyst complex component 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FRMD4B FERM domain containing 4B
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLIPR1 GLI pathogenesis-related 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HABP4 hyaluronan binding protein 4
HLA-DOA major histocompatibility complex, class II, DO alpha
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
ING4 inhibitor of growth family, member 4
IQCG IQ motif containing G
ITGA10 integrin, alpha 10
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
LIG4 ligase IV, DNA, ATP-dependent
LINC00341 long intergenic non-protein coding RNA 341
LOC157562 uncharacterized LOC157562
MAN1A2 mannosidase, alpha, class 1A, member 2
MBD2 methyl-CpG binding domain protein 2
MCL1 myeloid cell leukemia 1
MCOLN3 mucolipin 3
MED25 mediator complex subunit 25
MSH6 mutS homolog 6
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NOL12 nucleolar protein 12
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFML2A olfactomedin-like 2A
OSMR oncostatin M receptor
PEX11A peroxisomal biogenesis factor 11 alpha
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PICALM phosphatidylinositol binding clathrin assembly protein
POPDC3 popeye domain containing 3
POU4F1 POU class 4 homeobox 1
PRB1 proline-rich protein BstNI subfamily 1
PRKCH protein kinase C, eta
RAB5A RAB5A, member RAS oncogene family
RAD51B RAD51 paralog B
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RND2 Rho family GTPase 2
RUNX1 runt-related transcription factor 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SEC23A Sec23 homolog A (S. cerevisiae)
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SMAD5 SMAD family member 5
SNN stannin
SOS2 son of sevenless homolog 2 (Drosophila)
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SQLE squalene epoxidase
SRSF1 serine/arginine-rich splicing factor 1
STARD3 StAR-related lipid transfer (START) domain containing 3
STS steroid sulfatase (microsomal), isozyme S
STX2 syntaxin 2
SUGP1 SURP and G patch domain containing 1
SYNGR1 synaptogyrin 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TOR1AIP1 torsin A interacting protein 1
TRIM2 tripartite motif containing 2
VLDLR very low density lipoprotein receptor
ZC3H7B zinc finger CCCH-type containing 7B
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM15 ADAM metallopeptidase domain 15
ADRA2C adrenoceptor alpha 2C
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARC activity-regulated cytoskeleton-associated protein
B9D2 B9 protein domain 2
BTBD2 BTB (POZ) domain containing 2
CAMKMT calmodulin-lysine N-methyltransferase
CAPN15 calpain 15
CCDC130 coiled-coil domain containing 130
CCDC88C coiled-coil domain containing 88C
CCDC94 coiled-coil domain containing 94
CD79B CD79b molecule, immunoglobulin-associated beta
CDC20 cell division cycle 20
CENPE centromere protein E, 312kDa
CGA glycoprotein hormones, alpha polypeptide
CIC capicua transcriptional repressor
CLEC16A C-type lectin domain family 16, member A
CNN2 calponin 2
CORT cortistatin
CPSF3L cleavage and polyadenylation specific factor 3-like
CTNNBL1 catenin, beta like 1
CUL9 cullin 9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAL4 dynein, axonemal, light chain 4
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYSF dysferlin
ERI3 ERI1 exoribonuclease family member 3
FAM64A family with sequence similarity 64, member A
FKBPL FK506 binding protein like
GADD45G growth arrest and DNA-damage-inducible, gamma
GALE UDP-galactose-4-epimerase
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPATCH3 G patch domain containing 3
H1F0 H1 histone family, member 0
HIST1H1C histone cluster 1, H1c
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HJURP Holliday junction recognition protein
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI2-AS1 IDI2 antisense RNA 1
KCTD17 potassium channel tetramerization domain containing 17
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF13A kinesin family member 13A
KRT31 keratin 31, type I
LY6E lymphocyte antigen 6 complex, locus E
MAN2C1 mannosidase, alpha, class 2C, member 1
MED9 mediator complex subunit 9
MFSD12 major facilitator superfamily domain containing 12
MITF microphthalmia-associated transcription factor
MMP9 matrix metallopeptidase 9
MXD3 MAX dimerization protein 3
NEUROD4 neuronal differentiation 4
NFE2L3 nuclear factor, erythroid 2-like 3
NLRX1 NLR family member X1
NSD1 nuclear receptor binding SET domain protein 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OTUD3 OTU deubiquitinase 3
PADI1 peptidyl arginine deiminase, type I
PCDHB3 protocadherin beta 3
PLA2G3 phospholipase A2, group III
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PRR14L proline rich 14-like
PSRC1 proline/serine-rich coiled-coil 1
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RGS2 regulator of G-protein signaling 2
RHBDD3 rhomboid domain containing 3
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SMTN smoothelin
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPINK5 serine peptidase inhibitor, Kazal type 5
STEAP4 STEAP family member 4
SUSD6 sushi domain containing 6
TMEM121 transmembrane protein 121
TMEM39B transmembrane protein 39B
TNRC6B trinucleotide repeat containing 6B
TPCN1 two pore segment channel 1
TPST1 tyrosylprotein sulfotransferase 1
TSGA10 testis specific, 10
TUBA3D tubulin, alpha 3d
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP27X ubiquitin specific peptidase 27, X-linked
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB22 zinc finger and BTB domain containing 22
ZNF276 zinc finger protein 276
ZNF652 zinc finger protein 652
ZNF747 zinc finger protein 747
ZNF767P zinc finger family member 767, pseudogene
ZNF804A zinc finger protein 804A