pyrimethamine-4194 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the pyrimethamine-4194 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACOT11 acyl-CoA thioesterase 11
AGER advanced glycosylation end product-specific receptor
ARTN artemin
ATP9B ATPase, class II, type 9B
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BAGE B melanoma antigen
BBS9 Bardet-Biedl syndrome 9
C17ORF53 chromosome 17 open reading frame 53
C17ORF59 chromosome 17 open reading frame 59
CCDC186 coiled-coil domain containing 186
CCNG2 cyclin G2
CEMIP cell migration inducing protein, hyaluronan binding
CEP164 centrosomal protein 164kDa
CES3 carboxylesterase 3
CLCA2 chloride channel accessory 2
CTC1 CTS telomere maintenance complex component 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DMBT1 deleted in malignant brain tumors 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EHD2 EH-domain containing 2
EML3 echinoderm microtubule associated protein like 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FMO5 flavin containing monooxygenase 5
FN1 fibronectin 1
FUBP1 far upstream element (FUSE) binding protein 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GAL galanin/GMAP prepropeptide
GALC galactosylceramidase
GJA8 gap junction protein, alpha 8, 50kDa
GK3P glycerol kinase 3 pseudogene
GPR15 G protein-coupled receptor 15
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HOMER3 homer scaffolding protein 3
HOXB8 homeobox B8
ICOSLG inducible T-cell co-stimulator ligand
IFFO1 intermediate filament family orphan 1
IFT27 intraflagellar transport 27
IL11 interleukin 11
IQCK IQ motif containing K
KIAA1107 KIAA1107
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT37 keratin 37, type I
LAG3 lymphocyte-activation gene 3
LAMB4 laminin, beta 4
LDB2 LIM domain binding 2
LOC1720 dihydrofolate reductase pseudogene
LYRM9 LYR motif containing 9
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MYRF myelin regulatory factor
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOP14-AS1 NOP14 antisense RNA 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PELI2 pellino E3 ubiquitin protein ligase family member 2
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POU3F2 POU class 3 homeobox 2
PRKCA protein kinase C, alpha
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAB36 RAB36, member RAS oncogene family
RARB retinoic acid receptor, beta
RPL7 ribosomal protein L7
SAMD4A sterile alpha motif domain containing 4A
SCAPER S-phase cyclin A-associated protein in the ER
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH2D2A SH2 domain containing 2A
SIGLEC6 sialic acid binding Ig-like lectin 6
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOS2 son of sevenless homolog 2 (Drosophila)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTB spectrin, beta, erythrocytic
STC1 stanniocalcin 1
STOML1 stomatin (EPB72)-like 1
STON1 stonin 1
TDRKH tudor and KH domain containing
TFCP2L1 transcription factor CP2-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WFDC2 WAP four-disulfide core domain 2
WSB1 WD repeat and SOCS box containing 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZMYM5 zinc finger, MYM-type 5

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ADAM2 ADAM metallopeptidase domain 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARHGAP10 Rho GTPase activating protein 10
ARRB2 arrestin, beta 2
ATP13A2 ATPase type 13A2
C22ORF46 chromosome 22 open reading frame 46
CAPN15 calpain 15
CASS4 Cas scaffolding protein family member 4
CASZ1 castor zinc finger 1
CBX8 chromobox homolog 8
CCNT1 cyclin T1
CLTCL1 clathrin, heavy chain-like 1
CNN1 calponin 1, basic, smooth muscle
CTSF cathepsin F
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DNAH7 dynein, axonemal, heavy chain 7
EFNA3 ephrin-A3
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EPHB6 EPH receptor B6
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV4 ets variant 4
FAM186A family with sequence similarity 186, member A
FLT4 fms-related tyrosine kinase 4
GPR3 G protein-coupled receptor 3
H1F0 H1 histone family, member 0
HIST1H1D histone cluster 1, H1d
HIST1H1T histone cluster 1, H1t
HIST1H2AM histone cluster 1, H2am
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA4 homeobox A4
HOXA6 homeobox A6
HOXC13 homeobox C13
HSPA1L heat shock 70kDa protein 1-like
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
ISYNA1 inositol-3-phosphate synthase 1
ITGB7 integrin, beta 7
ITPKC inositol-trisphosphate 3-kinase C
KANSL3 KAT8 regulatory NSL complex subunit 3
KIAA0319L KIAA0319-like
KIAA1456 KIAA1456
KRT15 keratin 15, type I
KRT20 keratin 20, type I
KRT8P12 keratin 8 pseudogene 12
LIME1 Lck interacting transmembrane adaptor 1
LOC157562 uncharacterized LOC157562
LRRC61 leucine rich repeat containing 61
LTC4S leukotriene C4 synthase
LY6D lymphocyte antigen 6 complex, locus D
MDFI MyoD family inhibitor
MFGE8 milk fat globule-EGF factor 8 protein
MTCP1 mature T-cell proliferation 1
MTERF4 mitochondrial transcription termination factor 4
MYO1F myosin IF
NSUN6 NOP2/Sun domain family, member 6
NT5DC3 5'-nucleotidase domain containing 3
ODF2 outer dense fiber of sperm tails 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
ORAI3 ORAI calcium release-activated calcium modulator 3
OTUD3 OTU deubiquitinase 3
PACS1 phosphofurin acidic cluster sorting protein 1
PCDH12 protocadherin 12
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G15 phospholipase A2, group XV
PLBD1 phospholipase B domain containing 1
PLD3 phospholipase D family, member 3
PROX1 prospero homeobox 1
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCAI suppressor of cancer cell invasion
SENP7 SUMO1/sentrin specific peptidase 7
SNPH syntaphilin
SSBP3 single stranded DNA binding protein 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBC1D17 TBC1 domain family, member 17
TESPA1 thymocyte expressed, positive selection associated 1
TLN1 talin 1
TM7SF2 transmembrane 7 superfamily member 2
TPRA1 transmembrane protein, adipocyte asscociated 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UGT8 UDP glycosyltransferase 8
WDR18 WD repeat domain 18
ZNF16 zinc finger protein 16
ZNF222 zinc finger protein 222
ZNF428 zinc finger protein 428
ZNF816 zinc finger protein 816
ZYX zyxin