proxyphylline-6494 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the proxyphylline-6494 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ARC activity-regulated cytoskeleton-associated protein
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C8A complement component 8, alpha polypeptide
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCL23 chemokine (C-C motif) ligand 23
CD6 CD6 molecule
CDRT1 CMT1A duplicated region transcript 1
CFHR4 complement factor H-related 4
CLTA clathrin, light chain A
COL1A1 collagen, type I, alpha 1
CPA2 carboxypeptidase A2 (pancreatic)
CSN2 casein beta
EDN3 endothelin 3
ELOVL5 ELOVL fatty acid elongase 5
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETNK2 ethanolamine kinase 2
FFAR2 free fatty acid receptor 2
FGB fibrinogen beta chain
FGFR1 fibroblast growth factor receptor 1
FLJ11292
FRMPD1 FERM and PDZ domain containing 1
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLRX3 glutaredoxin 3
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPER1 G protein-coupled estrogen receptor 1
GRM4 glutamate receptor, metabotropic 4
GSTA3 glutathione S-transferase alpha 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGL immunoglobulin lambda locus
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1RN interleukin 1 receptor antagonist
INO80B INO80 complex subunit B
IQCE IQ motif containing E
IRF4 interferon regulatory factor 4
ISG20 interferon stimulated exonuclease gene 20kDa
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JPH3 junctophilin 3
KIF25-AS1 KIF25 antisense RNA 1
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRIT1 KRIT1, ankyrin repeat containing
KRTAP1-3 keratin associated protein 1-3
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAMB4 laminin, beta 4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LINC00652 long intergenic non-protein coding RNA 652
LPAL2 lipoprotein, Lp(a)-like 2, pseudogene
MAGEB2 melanoma antigen family B2
MALL mal, T-cell differentiation protein-like
MBD3 methyl-CpG binding domain protein 3
MDFI MyoD family inhibitor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MON2 MON2 homolog (S. cerevisiae)
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MPPE1 metallophosphoesterase 1
MVD mevalonate (diphospho) decarboxylase
MX1 MX dynamin-like GTPase 1
N4BP2L1 NEDD4 binding protein 2-like 1
NCKIPSD NCK interacting protein with SH3 domain
NID1 nidogen 1
NRN1 neuritin 1
OMG oligodendrocyte myelin glycoprotein
PDIA2 protein disulfide isomerase family A, member 2
PER1 period circadian clock 1
PLAC4 placenta-specific 4
PRB1 proline-rich protein BstNI subfamily 1
PTGFR prostaglandin F receptor (FP)
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RGS12 regulator of G-protein signaling 12
RTEL1 regulator of telomere elongation helicase 1
RUNX1 runt-related transcription factor 1
RUSC2 RUN and SH3 domain containing 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SND1-IT1 SND1 intronic transcript 1
TAPBPL TAP binding protein-like
TAS2R1 taste receptor, type 2, member 1
TBX6 T-box 6
THAP3 THAP domain containing, apoptosis associated protein 3
TLDC1 TBC/LysM-associated domain containing 1
TP63 tumor protein p63
TPP1 tripeptidyl peptidase I
TRIM49 tripartite motif containing 49
TUBA3C tubulin, alpha 3c
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AKTIP AKT interacting protein
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANO10 anoctamin 10
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARSB arylsulfatase B
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAX BCL2-associated X protein
BCL2L2 BCL2-like 2
BEX4 brain expressed, X-linked 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C12ORF4 chromosome 12 open reading frame 4
C1ORF56 chromosome 1 open reading frame 56
CAPN1 calpain 1, (mu/I) large subunit
CD82 CD82 molecule
CDC37 cell division cycle 37
CEP70 centrosomal protein 70kDa
CEP85 centrosomal protein 85kDa
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CLDN4 claudin 4
CLDND1 claudin domain containing 1
CLK1 CDC-like kinase 1
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CSTA cystatin A (stefin A)
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DAPK3 death-associated protein kinase 3
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DCAF13 DDB1 and CUL4 associated factor 13
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
EAF2 ELL associated factor 2
ECHDC2 enoyl CoA hydratase domain containing 2
EDAR ectodysplasin A receptor
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM169A family with sequence similarity 169, member A
FAM206A family with sequence similarity 206, member A
FANCE Fanconi anemia, complementation group E
FOXA1 forkhead box A1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GSTA4 glutathione S-transferase alpha 4
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2I general transcription factor IIi
HOXB2 homeobox B2
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IDI2-AS1 IDI2 antisense RNA 1
IGFBP6 insulin-like growth factor binding protein 6
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIF23 kinesin family member 23
LIME1 Lck interacting transmembrane adaptor 1
LIN7B lin-7 homolog B (C. elegans)
LOC257152 uncharacterized LOC257152
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYRM9 LYR motif containing 9
MAGEH1 melanoma antigen family H1
MANBA mannosidase, beta A, lysosomal
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEIS1 Meis homeobox 1
MOCS3 molybdenum cofactor synthesis 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NFE2L3 nuclear factor, erythroid 2-like 3
NNT nicotinamide nucleotide transhydrogenase
OSGEP O-sialoglycoprotein endopeptidase
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDHB3 protocadherin beta 3
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PECR peroxisomal trans-2-enoyl-CoA reductase
PHC1 polyhomeotic homolog 1 (Drosophila)
PITX2 paired-like homeodomain 2
PTPRG protein tyrosine phosphatase, receptor type, G
QTRT1 queuine tRNA-ribosyltransferase 1
RBL1 retinoblastoma-like 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF146 ring finger protein 146
RNF170 ring finger protein 170
RNF31 ring finger protein 31
RPGR retinitis pigmentosa GTPase regulator
RWDD3 RWD domain containing 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SDC3 syndecan 3
SLC12A8 solute carrier family 12, member 8
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNC syncoilin, intermediate filament protein
TCTN1 tectonic family member 1
TEAD3 TEA domain family member 3
TMEM104 transmembrane protein 104
TMEM51 transmembrane protein 51
UBOX5 U-box domain containing 5
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF141 zinc finger protein 141
ZNF331 zinc finger protein 331
ZNF557 zinc finger protein 557
ZNF804A zinc finger protein 804A