proxymetacaine-6332 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the proxymetacaine-6332 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AFF2 AF4/FMR2 family, member 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARHGAP35 Rho GTPase activating protein 35
ASPN asporin
ASTN2 astrotactin 2
B9D1 B9 protein domain 1
BAAT bile acid CoA:amino acid N-acyltransferase
BAGE B melanoma antigen
C17ORF53 chromosome 17 open reading frame 53
C1ORF105 chromosome 1 open reading frame 105
C8A complement component 8, alpha polypeptide
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CALD1 caldesmon 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CDK6 cyclin-dependent kinase 6
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDRT1 CMT1A duplicated region transcript 1
CEP68 centrosomal protein 68kDa
CFAP45 cilia and flagella associated protein 45
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CRTC1 CREB regulated transcription coactivator 1
CSNK1E casein kinase 1, epsilon
CTNND2 catenin (cadherin-associated protein), delta 2
CUZD1 CUB and zona pellucida-like domains 1
CYTH1 cytohesin 1
CYTH3 cytohesin 3
DEFA4 defensin, alpha 4, corticostatin
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DMBT1 deleted in malignant brain tumors 1
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DPF3 D4, zinc and double PHD fingers, family 3
EMP1 epithelial membrane protein 1
ERF Ets2 repressor factor
FAM13A family with sequence similarity 13, member A
FAM65B family with sequence similarity 65, member B
FDPS farnesyl diphosphate synthase
FLRT2 fibronectin leucine rich transmembrane protein 2
FRZB frizzled-related protein
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GTDC1 glycosyltransferase-like domain containing 1
HOXC10 homeobox C10
HSF2BP heat shock transcription factor 2 binding protein
HYAL4 hyaluronoglucosaminidase 4
IGHA1 immunoglobulin heavy constant alpha 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNIP1 Kv channel interacting protein 1
KLF12 Kruppel-like factor 12
KRT86 keratin 86, type II
LHX2 LIM homeobox 2
LIMD1 LIM domains containing 1
LMOD1 leiomodin 1 (smooth muscle)
LOC100131532 uncharacterized LOC100131532
LSP1 lymphocyte-specific protein 1
LTBP4 latent transforming growth factor beta binding protein 4
MAPT microtubule-associated protein tau
MBD3 methyl-CpG binding domain protein 3
MDFI MyoD family inhibitor
MON1B MON1 secretory trafficking family member B
NCOR2 nuclear receptor corepressor 2
NDOR1 NADPH dependent diflavin oxidoreductase 1
NOX1 NADPH oxidase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NSD1 nuclear receptor binding SET domain protein 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PEX11A peroxisomal biogenesis factor 11 alpha
PRAMEF12 PRAME family member 12
PRDX2 peroxiredoxin 2
PTBP3 polypyrimidine tract binding protein 3
PVT1 Pvt1 oncogene (non-protein coding)
PYHIN1 pyrin and HIN domain family, member 1
RAB36 RAB36, member RAS oncogene family
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF39 ring finger protein 39
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SETD8 SET domain containing (lysine methyltransferase) 8
SFTPB surfactant protein B
SLA Src-like-adaptor
SNX13 sorting nexin 13
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPTA1 spectrin, alpha, erythrocytic 1
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SSX3 synovial sarcoma, X breakpoint 3
STK24 serine/threonine kinase 24
TBC1D17 TBC1 domain family, member 17
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM49 tripartite motif containing 49
UBXN1 UBX domain protein 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WDR1 WD repeat domain 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase

decreased expression

Symbol Name
ADCY7 adenylate cyclase 7
ADGRG2 adhesion G protein-coupled receptor G2
AFAP1 actin filament associated protein 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP1AR adaptor-related protein complex 1 associated regulatory protein
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARL15 ADP-ribosylation factor-like 15
ATAD2B ATPase family, AAA domain containing 2B
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BLMH bleomycin hydrolase
C11ORF63 chromosome 11 open reading frame 63
C1ORF159 chromosome 1 open reading frame 159
C5 complement component 5
CCDC47 coiled-coil domain containing 47
CCNJ cyclin J
CENPQ centromere protein Q
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHD8 chromodomain helicase DNA binding protein 8
CHEK2 checkpoint kinase 2
CHST10 carbohydrate sulfotransferase 10
CLCF1 cardiotrophin-like cytokine factor 1
CLCN2 chloride channel, voltage-sensitive 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CUL9 cullin 9
DENND4B DENN/MADD domain containing 4B
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYSF dysferlin
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ERCC2 excision repair cross-complementation group 2
EXOSC9 exosome component 9
FAM131A family with sequence similarity 131, member A
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR176 G protein-coupled receptor 176
GSR glutathione reductase
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL11RA interleukin 11 receptor, alpha
INF2 inverted formin, FH2 and WH2 domain containing
IRF9 interferon regulatory factor 9
ITPKB inositol-trisphosphate 3-kinase B
JMJD4 jumonji domain containing 4
KIAA0232 KIAA0232
KIAA0753 KIAA0753
KRT75 keratin 75, type II
LMNB1 lamin B1
LYPD1 LY6/PLAUR domain containing 1
MTG1 mitochondrial ribosome-associated GTPase 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NRSN2 neurensin 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDGFD platelet derived growth factor D
PDIA3 protein disulfide isomerase family A, member 3
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
POMT2 protein-O-mannosyltransferase 2
POR P450 (cytochrome) oxidoreductase
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
QTRT1 queuine tRNA-ribosyltransferase 1
RBM38 RNA binding motif protein 38
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SALL2 spalt-like transcription factor 2
SCG5 secretogranin V
SCPEP1 serine carboxypeptidase 1
SHROOM2 shroom family member 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SND1-IT1 SND1 intronic transcript 1
SNPH syntaphilin
SPATA2L spermatogenesis associated 2-like
SPEG SPEG complex locus
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNPO synaptopodin
SYTL2 synaptotagmin-like 2
TAOK1 TAO kinase 1
TBK1 TANK-binding kinase 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMC7 transmembrane channel-like 7
TMEM134 transmembrane protein 134
TMEM8A transmembrane protein 8A
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTC4 tetratricopeptide repeat domain 4
UNC45A unc-45 homolog A (C. elegans)
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WDR91 WD repeat domain 91
ZBTB48 zinc finger and BTB domain containing 48
ZC3H12A zinc finger CCCH-type containing 12A
ZNF350 zinc finger protein 350
ZNF629 zinc finger protein 629
ZNF668 zinc finger protein 668