protriptyline-6338 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the protriptyline-6338 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
AKAP17A A kinase (PRKA) anchor protein 17A
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANG angiogenin, ribonuclease, RNase A family, 5
ANKLE2 ankyrin repeat and LEM domain containing 2
ARHGAP44 Rho GTPase activating protein 44
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARID1A AT rich interactive domain 1A (SWI-like)
ATF6B activating transcription factor 6 beta
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCDC71 coiled-coil domain containing 71
CCNG2 cyclin G2
CDC14B cell division cycle 14B
CDC25C cell division cycle 25C
CDK13 cyclin-dependent kinase 13
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHD7 chromodomain helicase DNA binding protein 7
COL1A1 collagen, type I, alpha 1
CRTC1 CREB regulated transcription coactivator 1
CSF1R colony stimulating factor 1 receptor
CTH cystathionine gamma-lyase
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DCAF11 DDB1 and CUL4 associated factor 11
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DST dystonin
DZIP1 DAZ interacting zinc finger protein 1
EFNA3 ephrin-A3
EGFR epidermal growth factor receptor
ELAC2 elaC ribonuclease Z 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELSPBP1 epididymal sperm binding protein 1
EMP1 epithelial membrane protein 1
FGL1 fibrinogen-like 1
FOXG1 forkhead box G1
FUT2 fucosyltransferase 2 (secretor status included)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAS8 growth arrest-specific 8
GLP1R glucagon-like peptide 1 receptor
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOOK1 hook microtubule-tethering protein 1
HOXC10 homeobox C10
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ICOSLG inducible T-cell co-stimulator ligand
IFT122 intraflagellar transport 122
IL16 interleukin 16
IL1A interleukin 1, alpha
INPP5J inositol polyphosphate-5-phosphatase J
INSIG1 insulin induced gene 1
KLK2 kallikrein-related peptidase 2
KYNU kynureninase
LIG4 ligase IV, DNA, ATP-dependent
LOC81691 exonuclease NEF-sp
LPAR4 lysophosphatidic acid receptor 4
MEGF9 multiple EGF-like-domains 9
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MYOF myoferlin
NCAPH2 non-SMC condensin II complex, subunit H2
NF1 neurofibromin 1
NNAT neuronatin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRXN3 neurexin 3
OLFML3 olfactomedin-like 3
OR3A3 olfactory receptor, family 3, subfamily A, member 3
OSBPL10 oxysterol binding protein-like 10
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDB1 pleckstrin homology-like domain, family B, member 1
POFUT1 protein O-fucosyltransferase 1
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PURA purine-rich element binding protein A
RNASE4 ribonuclease, RNase A family, 4
RPS3A ribosomal protein S3A
S100A1 S100 calcium binding protein A1
SAP30 Sin3A-associated protein, 30kDa
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A6 solute carrier family 16, member 6
SLC22A17 solute carrier family 22, member 17
SMAD7 SMAD family member 7
SPRR1B small proline-rich protein 1B
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TAPBP TAP binding protein (tapasin)
TBXA2R thromboxane A2 receptor
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TSGA10 testis specific, 10
WDR1 WD repeat domain 1

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L2 BCL2-like 2
BCL9 B-cell CLL/lymphoma 9
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C11ORF73 chromosome 11 open reading frame 73
C11ORF80 chromosome 11 open reading frame 80
CABIN1 calcineurin binding protein 1
CCDC106 coiled-coil domain containing 106
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTSD cathepsin D
CTSF cathepsin F
ECM1 extracellular matrix protein 1
EDC3 enhancer of mRNA decapping 3
EXOSC9 exosome component 9
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FPGS folylpolyglutamate synthase
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FUZ fuzzy planar cell polarity protein
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNL1 guanine nucleotide binding protein-like 1
HIRA histone cell cycle regulator
HIST1H3G histone cluster 1, H3g
HOXA4 homeobox A4
HPS6 Hermansky-Pudlak syndrome 6
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPA2 heat shock 70kDa protein 2
HYAL3 hyaluronoglucosaminidase 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL17RA interleukin 17 receptor A
INF2 inverted formin, FH2 and WH2 domain containing
ITGA10 integrin, alpha 10
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KDM5C lysine (K)-specific demethylase 5C
KIF13B kinesin family member 13B
KRI1 KRI1 homolog (S. cerevisiae)
KRT75 keratin 75, type II
LMBR1L limb development membrane protein 1-like
LMNB2 lamin B2
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MCRS1 microspherule protein 1
MISP mitotic spindle positioning
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MT1M metallothionein 1M
MTG1 mitochondrial ribosome-associated GTPase 1
MUTYH mutY homolog
MYBBP1A MYB binding protein (P160) 1a
NAT10 N-acetyltransferase 10 (GCN5-related)
NECAB3 N-terminal EF-hand calcium binding protein 3
NT5E 5'-nucleotidase, ecto (CD73)
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PCBP4 poly(rC) binding protein 4
PILRB paired immunoglobin-like type 2 receptor beta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
POMT2 protein-O-mannosyltransferase 2
PPCDC phosphopantothenoylcysteine decarboxylase
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PRPH peripherin
PYCRL pyrroline-5-carboxylate reductase-like
RAB3A RAB3A, member RAS oncogene family
RIN1 Ras and Rab interactor 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETMAR SET domain and mariner transposase fusion gene
SLC10A3 solute carrier family 10, member 3
SLC12A9 solute carrier family 12, member 9
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SMAD5 SMAD family member 5
SUGCT succinyl-CoA:glutarate-CoA transferase
SUGP1 SURP and G patch domain containing 1
SYNPO synaptopodin
TAOK1 TAO kinase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TH tyrosine hydroxylase
TMEM120B transmembrane protein 120B
TMEM134 transmembrane protein 134
TMEM183A transmembrane protein 183A
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM66 tripartite motif containing 66
TSPAN1 tetraspanin 1
TSPYL2 TSPY-like 2
TUBA3D tubulin, alpha 3d
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR91 WD repeat domain 91
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XYLT2 xylosyltransferase II
ZBED1 zinc finger, BED-type containing 1
ZNF671 zinc finger protein 671
ZNF696 zinc finger protein 696