protriptyline-3119 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the protriptyline-3119 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
AFF4 AF4/FMR2 family, member 4
AKAP8L A kinase (PRKA) anchor protein 8-like
AKT2 v-akt murine thymoma viral oncogene homolog 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF6B activating transcription factor 6 beta
ATP9A ATPase, class II, type 9A
ATXN8OS ATXN8 opposite strand (non-protein coding)
AURKA aurora kinase A
BCAS1 breast carcinoma amplified sequence 1
BTN2A2 butyrophilin, subfamily 2, member A2
C4ORF19 chromosome 4 open reading frame 19
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDON cell adhesion associated, oncogene regulated
CLTA clathrin, light chain A
COL9A3 collagen, type IX, alpha 3
CTSE cathepsin E
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DOCK6 dedicator of cytokinesis 6
DPYSL3 dihydropyrimidinase-like 3
DRD2 dopamine receptor D2
EFNB2 ephrin-B2
EFR3B EFR3 homolog B (S. cerevisiae)
EIF1 eukaryotic translation initiation factor 1
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ESR1 estrogen receptor 1
F2R coagulation factor II (thrombin) receptor
FAM120C family with sequence similarity 120C
FAM127B family with sequence similarity 127, member B
FRAS1 Fraser extracellular matrix complex subunit 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GLYAT glycine-N-acyltransferase
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAP1 huntingtin-associated protein 1
HBB hemoglobin, beta
HLA-DOA major histocompatibility complex, class II, DO alpha
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMOX1 heme oxygenase 1
HYAL1 hyaluronoglucosaminidase 1
IFT27 intraflagellar transport 27
IGFBP5 insulin-like growth factor binding protein 5
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INF2 inverted formin, FH2 and WH2 domain containing
KLHL25 kelch-like family member 25
LDLR low density lipoprotein receptor
LOC257152 uncharacterized LOC257152
LPAL2 lipoprotein, Lp(a)-like 2, pseudogene
MAOA monoamine oxidase A
MAPK11 mitogen-activated protein kinase 11
MAST2 microtubule associated serine/threonine kinase 2
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MOBP myelin-associated oligodendrocyte basic protein
MORN1 MORN repeat containing 1
MTCL1 microtubule crosslinking factor 1
MTRF1L mitochondrial translational release factor 1-like
NBL1 neuroblastoma 1, DAN family BMP antagonist
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAX2 paired box 2
PCDHA9 protocadherin alpha 9
PDGFB platelet-derived growth factor beta polypeptide
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEG10 paternally expressed 10
PEX6 peroxisomal biogenesis factor 6
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POU6F1 POU class 6 homeobox 1
PRPH peripherin
PTCRA pre T-cell antigen receptor alpha
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RETN resistin
RGS14 regulator of G-protein signaling 14
RRBP1 ribosome binding protein 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RYR2 ryanodine receptor 2 (cardiac)
SCIN scinderin
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SNAI1 snail family zinc finger 1
SOX13 SRY (sex determining region Y)-box 13
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SRR serine racemase
STMN4 stathmin-like 4
SYT13 synaptotagmin XIII
TAS2R9 taste receptor, type 2, member 9
TBX2 T-box 2
TEAD3 TEA domain family member 3
TEX40 testis expressed 40
TICAM1 toll-like receptor adaptor molecule 1
TM4SF4 transmembrane 4 L six family member 4
WASF3 WAS protein family, member 3
WDR4 WD repeat domain 4
YPEL1 yippee-like 1 (Drosophila)
ZC3H7B zinc finger CCCH-type containing 7B
ZNF696 zinc finger protein 696

decreased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALPK1 alpha-kinase 1
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARL15 ADP-ribosylation factor-like 15
ARL2 ADP-ribosylation factor-like 2
ARRB1 arrestin, beta 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD3A ATPase family, AAA domain containing 3A
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BATF basic leucine zipper transcription factor, ATF-like
BTBD18 BTB (POZ) domain containing 18
C14ORF93 chromosome 14 open reading frame 93
C7ORF43 chromosome 7 open reading frame 43
C8ORF60 chromosome 8 open reading frame 60
CCNJ cyclin J
CD69 CD69 molecule
COL15A1 collagen, type XV, alpha 1
CORT cortistatin
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CXORF56 chromosome X open reading frame 56
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYSLTR1 cysteinyl leukotriene receptor 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEPDC1 DEP domain containing 1
ERCC2 excision repair cross-complementation group 2
FAM204A family with sequence similarity 204, member A
FOXN2 forkhead box N2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GLTSCR1 glioma tumor suppressor candidate region gene 1
GSTA4 glutathione S-transferase alpha 4
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H1E histone cluster 1, H1e
HIST1H2BC histone cluster 1, H2bc
IGLV1-44 immunoglobulin lambda variable 1-44
IL12B interleukin 12B
IPO4 importin 4
IRF7 interferon regulatory factor 7
JADE3 jade family PHD finger 3
JUNB jun B proto-oncogene
KPTN kaptin (actin binding protein)
LIMD2 LIM domain containing 2
LPAR6 lysophosphatidic acid receptor 6
LRRK1 leucine-rich repeat kinase 1
LY6E lymphocyte antigen 6 complex, locus E
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MED22 mediator complex subunit 22
METTL2B methyltransferase like 2B
METTL8 methyltransferase like 8
MLYCD malonyl-CoA decarboxylase
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MMP9 matrix metallopeptidase 9
MTCP1 mature T-cell proliferation 1
MTG1 mitochondrial ribosome-associated GTPase 1
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MXD3 MAX dimerization protein 3
MYBPH myosin binding protein H
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NABP1 nucleic acid binding protein 1
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOL6 nucleolar protein 6 (RNA-associated)
NR1H3 nuclear receptor subfamily 1, group H, member 3
PAQR4 progestin and adipoQ receptor family member IV
PHC1 polyhomeotic homolog 1 (Drosophila)
PIAS3 protein inhibitor of activated STAT, 3
PILRB paired immunoglobin-like type 2 receptor beta
PLCD1 phospholipase C, delta 1
PMCH pro-melanin-concentrating hormone
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPOX protoporphyrinogen oxidase
PRDM1 PR domain containing 1, with ZNF domain
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRP1 ribosomal RNA processing 1
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SALL2 spalt-like transcription factor 2
SCAI suppressor of cancer cell invasion
SIRT6 sirtuin 6
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC35F6 solute carrier family 35, member F6
SOGA1 suppressor of glucose, autophagy associated 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
TASP1 taspase, threonine aspartase, 1
TCEA2 transcription elongation factor A (SII), 2
TGM5 transglutaminase 5
TRDMT1 tRNA aspartic acid methyltransferase 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
WDR3 WD repeat domain 3
WDR46 WD repeat domain 46
YOD1 YOD1 deubiquitinase
ZC3H12A zinc finger CCCH-type containing 12A
ZHX2 zinc fingers and homeoboxes 2
ZNF480 zinc finger protein 480
ZNF593 zinc finger protein 593
ZNF93 zinc finger protein 93