protoveratrine A-6618 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the protoveratrine A-6618 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
AKT2 v-akt murine thymoma viral oncogene homolog 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATAD5 ATPase family, AAA domain containing 5
ATXN2L ataxin 2-like
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTG2 BTG family, member 2
C11ORF16 chromosome 11 open reading frame 16
C1ORF54 chromosome 1 open reading frame 54
C1QTNF3 C1q and tumor necrosis factor related protein 3
C8A complement component 8, alpha polypeptide
CCL27 chemokine (C-C motif) ligand 27
CD34 CD34 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD93 CD93 molecule
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLEC11A C-type lectin domain family 11, member A
CPA4 carboxypeptidase A4
CREBZF CREB/ATF bZIP transcription factor
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DCTN2 dynactin 2 (p50)
DENND2A DENN/MADD domain containing 2A
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DNAAF1 dynein, axonemal, assembly factor 1
ELL2 elongation factor, RNA polymerase II, 2
ELSPBP1 epididymal sperm binding protein 1
ESR1 estrogen receptor 1
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FDPS farnesyl diphosphate synthase
FGF1 fibroblast growth factor 1 (acidic)
FGFR1 fibroblast growth factor receptor 1
FLT1 fms-related tyrosine kinase 1
GAS7 growth arrest-specific 7
GLB1L galactosidase, beta 1-like
GLRX3 glutaredoxin 3
GSK3A glycogen synthase kinase 3 alpha
GSTM5 glutathione S-transferase mu 5
GYPC glycophorin C (Gerbich blood group)
ITGB8 integrin, beta 8
IVL involucrin
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF21B kinesin family member 21B
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LAT2 linker for activation of T cells family, member 2
LDHC lactate dehydrogenase C
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MED25 mediator complex subunit 25
MEF2C myocyte enhancer factor 2C
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MORN1 MORN repeat containing 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NME8 NME/NM23 family member 8
NPIPB3 nuclear pore complex interacting protein family, member B3
NYNRIN NYN domain and retroviral integrase containing
PALM paralemmin
PEX26 peroxisomal biogenesis factor 26
PGAM2 phosphoglycerate mutase 2 (muscle)
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIGR polymeric immunoglobulin receptor
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLCH1 phospholipase C, eta 1
PLK4 polo-like kinase 4
POMT2 protein-O-mannosyltransferase 2
POU2F2 POU class 2 homeobox 2
POU5F1B POU class 5 homeobox 1B
PTCRA pre T-cell antigen receptor alpha
RAB36 RAB36, member RAS oncogene family
RAB40A RAB40A, member RAS oncogene family
RASAL2 RAS protein activator like 2
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC22A14 solute carrier family 22, member 14
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC1A structural maintenance of chromosomes 1A
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SSX3 synovial sarcoma, X breakpoint 3
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TACR1 tachykinin receptor 1
TCF12 transcription factor 12
THOC5 THO complex 5
THRB thyroid hormone receptor, beta
TLK1 tousled-like kinase 1
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TUBA3C tubulin, alpha 3c
VAMP5 vesicle-associated membrane protein 5
VGF VGF nerve growth factor inducible
WWOX WW domain containing oxidoreductase
ZNF516 zinc finger protein 516
ZNF74 zinc finger protein 74
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACVR2B activin A receptor, type IIB
ADTRP androgen-dependent TFPI-regulating protein
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMT aminomethyltransferase
ANKRD36 ankyrin repeat domain 36
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAHCC1 BAH domain and coiled-coil containing 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BEND5 BEN domain containing 5
BTC betacellulin
C16ORF62 chromosome 16 open reading frame 62
C1ORF105 chromosome 1 open reading frame 105
C8ORF60 chromosome 8 open reading frame 60
CARD8 caspase recruitment domain family, member 8
CCNO cyclin O
CCP110 centriolar coiled coil protein 110kDa
CEMIP cell migration inducing protein, hyaluronan binding
CFHR2 complement factor H-related 2
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DENND2D DENN/MADD domain containing 2D
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ERF Ets2 repressor factor
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM186A family with sequence similarity 186, member A
FAT4 FAT atypical cadherin 4
FBRS fibrosin
FBXO40 F-box protein 40
GEMIN8 gem (nuclear organelle) associated protein 8
GPNMB glycoprotein (transmembrane) nmb
GSTCD glutathione S-transferase, C-terminal domain containing
HDAC11 histone deacetylase 11
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1D histone cluster 1, H1d
IGFLR1 IGF-like family receptor 1
IL11RA interleukin 11 receptor, alpha
KDM7A lysine (K)-specific demethylase 7A
KIAA0895 KIAA0895
KIF13B kinesin family member 13B
KLHL4 kelch-like family member 4
KLK5 kallikrein-related peptidase 5
KRT20 keratin 20, type I
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMCD1 LIM and cysteine-rich domains 1
LY96 lymphocyte antigen 96
MAN2C1 mannosidase, alpha, class 2C, member 1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MDM4 MDM4, p53 regulator
MMP2 matrix metallopeptidase 2
MYL9 myosin, light chain 9, regulatory
NDRG4 NDRG family member 4
NME5 NME/NM23 family member 5
NSUN6 NOP2/Sun domain family, member 6
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OLFML2B olfactomedin-like 2B
PARP3 poly (ADP-ribose) polymerase family, member 3
PC pyruvate carboxylase
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PGPEP1 pyroglutamyl-peptidase I
PLD2 phospholipase D2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PTGES2 prostaglandin E synthase 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAD54L2 RAD54-like 2 (S. cerevisiae)
RARS arginyl-tRNA synthetase
RNF39 ring finger protein 39
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SAYSD1 SAYSVFN motif domain containing 1
SCARA3 scavenger receptor class A, member 3
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SH3GL2 SH3-domain GRB2-like 2
SIX3 SIX homeobox 3
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STARD5 StAR-related lipid transfer (START) domain containing 5
STIM1 stromal interaction molecule 1
TEX40 testis expressed 40
TMEM51 transmembrane protein 51
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAIP TRAF interacting protein
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBA4B tubulin, alpha 4b
UNC119 unc-119 homolog (C. elegans)
WDR4 WD repeat domain 4
WDR62 WD repeat domain 62
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB22 zinc finger and BTB domain containing 22
ZMAT5 zinc finger, matrin-type 5
ZNF214 zinc finger protein 214
ZNF268 zinc finger protein 268
ZNF549 zinc finger protein 549