protoveratrine A-2800 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the protoveratrine A-2800 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ALLC allantoicase
ALS2CL ALS2 C-terminal like
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGAP1 Rho GTPase activating protein 1
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAIAP3 BAI1-associated protein 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP295 centrosomal protein 295kDa
CGA glycoprotein hormones, alpha polypeptide
COL19A1 collagen, type XIX, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPQ carboxypeptidase Q
CRMP1 collapsin response mediator protein 1
CTSF cathepsin F
CTSZ cathepsin Z
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DFNB31 deafness, autosomal recessive 31
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DVL2 dishevelled segment polarity protein 2
EMID1 EMI domain containing 1
ERP44 endoplasmic reticulum protein 44
F13A1 coagulation factor XIII, A1 polypeptide
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FRMD1 FERM domain containing 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GMPR guanosine monophosphate reductase
GRPR gastrin-releasing peptide receptor
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HFE hemochromatosis
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HNF1B HNF1 homeobox B
HOMER3 homer scaffolding protein 3
IGF1R insulin-like growth factor 1 receptor
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
JADE2 jade family PHD finger 2
JAM3 junctional adhesion molecule 3
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KLHDC8A kelch domain containing 8A
KRT19P2 keratin 19 pseudogene 2
LAMP1 lysosomal-associated membrane protein 1
LOXL3 lysyl oxidase-like 3
LTBP2 latent transforming growth factor beta binding protein 2
MAP1A microtubule-associated protein 1A
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIA melanoma inhibitory activity
MMP25 matrix metallopeptidase 25
NDRG2 NDRG family member 2
NOD2 nucleotide-binding oligomerization domain containing 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ONECUT2 one cut homeobox 2
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PACS1 phosphofurin acidic cluster sorting protein 1
PARP11 poly (ADP-ribose) polymerase family, member 11
PGLYRP4 peptidoglycan recognition protein 4
PHLDB1 pleckstrin homology-like domain, family B, member 1
PKNOX2 PBX/knotted 1 homeobox 2
PLD1 phospholipase D1, phosphatidylcholine-specific
POPDC3 popeye domain containing 3
PPP5C protein phosphatase 5, catalytic subunit
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB3A RAB3A, member RAS oncogene family
RBFA ribosome binding factor A (putative)
RER1 retention in endoplasmic reticulum sorting receptor 1
RNF19B ring finger protein 19B
ROM1 retinal outer segment membrane protein 1
RRBP1 ribosome binding protein 1
RUNX1 runt-related transcription factor 1
RYR2 ryanodine receptor 2 (cardiac)
SCAPER S-phase cyclin A-associated protein in the ER
SFRP4 secreted frizzled-related protein 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SOAT2 sterol O-acyltransferase 2
SORBS1 sorbin and SH3 domain containing 1
SPRR1B small proline-rich protein 1B
SRCAP Snf2-related CREBBP activator protein
SRPK2 SRSF protein kinase 2
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNK2 tyrosine kinase, non-receptor, 2
TRIB2 tribbles pseudokinase 2
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP36 ubiquitin specific peptidase 36
UTS2 urotensin 2
VASH1 vasohibin 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF37BP zinc finger protein 37B, pseudogene
ZNF76 zinc finger protein 76
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ARMC7 armadillo repeat containing 7
ARSB arylsulfatase B
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C1ORF115 chromosome 1 open reading frame 115
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMK1 calcium/calmodulin-dependent protein kinase I
CBR1 carbonyl reductase 1
CENPO centromere protein O
CEP85 centrosomal protein 85kDa
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CRY2 cryptochrome circadian clock 2
CUEDC1 CUE domain containing 1
DEAF1 DEAF1 transcription factor
DOCK1 dedicator of cytokinesis 1
EDC4 enhancer of mRNA decapping 4
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ELOVL4 ELOVL fatty acid elongase 4
FAM50B family with sequence similarity 50, member B
FAM86C1 family with sequence similarity 86, member C1
FLCN folliculin
GK3P glycerol kinase 3 pseudogene
GLB1L2 galactosidase, beta 1-like 2
GMIP GEM interacting protein
GRB7 growth factor receptor-bound protein 7
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
INPP5J inositol polyphosphate-5-phosphatase J
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0355 KIAA0355
KIAA0430 KIAA0430
LAMB1 laminin, beta 1
LOC100287590 uncharacterized LOC100287590
LRRC61 leucine rich repeat containing 61
LY6E lymphocyte antigen 6 complex, locus E
LYPD1 LY6/PLAUR domain containing 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MANBA mannosidase, beta A, lysosomal
MBTD1 mbt domain containing 1
MED15 mediator complex subunit 15
MITF microphthalmia-associated transcription factor
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NDE1 nudE neurodevelopment protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NIPAL2 NIPA-like domain containing 2
NME6 NME/NM23 nucleoside diphosphate kinase 6
NOL10 nucleolar protein 10
NPFFR1 neuropeptide FF receptor 1
NUBPL nucleotide binding protein-like
OLFML3 olfactomedin-like 3
PC pyruvate carboxylase
PCBP4 poly(rC) binding protein 4
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PEX11A peroxisomal biogenesis factor 11 alpha
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCG1 phospholipase C, gamma 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PTK6 protein tyrosine kinase 6
PTPRE protein tyrosine phosphatase, receptor type, E
QTRT1 queuine tRNA-ribosyltransferase 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPIA ribose 5-phosphate isomerase A
RPL13P5 ribosomal protein L13 pseudogene 5
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIX1 SIX homeobox 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPIDR scaffolding protein involved in DNA repair
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SSFA2 sperm specific antigen 2
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TESK2 testis-specific kinase 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM209 transmembrane protein 209
TMEM62 transmembrane protein 62
TMOD1 tropomodulin 1
TUBA3C tubulin, alpha 3c
TWSG1 twisted gastrulation BMP signaling modulator 1
UBXN8 UBX domain protein 8
ULBP2 UL16 binding protein 2
USP27X ubiquitin specific peptidase 27, X-linked
VWA1 von Willebrand factor A domain containing 1
ZBTB6 zinc finger and BTB domain containing 6
ZNF10 zinc finger protein 10
ZNF329 zinc finger protein 329
ZNF408 zinc finger protein 408
ZNF710 zinc finger protein 710