proteinaceous extracellular matrix Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. (Gene Ontology, GO_0005578)
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Genes

369 proteins localized to the proteinaceous extracellular matrix cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PODN podocan 0.663342
WNT9A wingless-type MMTV integration site family, member 9A 0.663342
MMP19 matrix metallopeptidase 19 0.663342
MMP17 matrix metallopeptidase 17 (membrane-inserted) 0.663342
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.663342
ASPN asporin 0.663342
LTBP4 latent transforming growth factor beta binding protein 4 0.663342
COL12A1 collagen, type XII, alpha 1 0.663342
LTBP1 latent transforming growth factor beta binding protein 1 0.663342
WNT5A wingless-type MMTV integration site family, member 5A 0.663342
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 0.663342
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.663342
AMELY amelogenin, Y-linked 0.663342
AMELX amelogenin, X-linked 0.663342
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.663342
DSPP dentin sialophosphoprotein 0.663342
RBP3 retinol binding protein 3, interstitial 0.663342
COL4A2 collagen, type IV, alpha 2 0.663342
COL4A1 collagen, type IV, alpha 1 0.663342
COL19A1 collagen, type XIX, alpha 1 0.663342
COL5A3 collagen, type V, alpha 3 0.663342
AMBN ameloblastin (enamel matrix protein) 0.663342
WNT11 wingless-type MMTV integration site family, member 11 0.663342
COL11A2 collagen, type XI, alpha 2 0.663342
COL11A1 collagen, type XI, alpha 1 0.663342
ZP4 zona pellucida glycoprotein 4 0.663342
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 0.663342
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.663342
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 0.663342
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.663342
ODAM odontogenic, ameloblast asssociated 0.663342
ELN elastin 0.663342
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.663342
WNT2B wingless-type MMTV integration site family, member 2B 0.663342
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 0.663342
MMP2 matrix metallopeptidase 2 0.663342
WNT5B wingless-type MMTV integration site family, member 5B 0.663342
TIMP3 TIMP metallopeptidase inhibitor 3 0.663342
HAPLN1 hyaluronan and proteoglycan link protein 1 0.663342
ECM1 extracellular matrix protein 1 0.663342
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 0.663342
AGRN agrin 0.663342
MATN2 matrilin 2 0.663342
COL4A4 collagen, type IV, alpha 4 0.663342
LAMC2 laminin, gamma 2 0.663342
FBLN1 fibulin 1 0.663342
FBLN2 fibulin 2 0.663342
COL26A1 collagen, type XXVI, alpha 1 0.663342
ADAMTSL5 ADAMTS-like 5 0.663342
PRELP proline/arginine-rich end leucine-rich repeat protein 0.663342
SFTPD surfactant protein D 0.663342
LUM lumican 0.663342
COL15A1 collagen, type XV, alpha 1 0.663342
TGFBI transforming growth factor, beta-induced, 68kDa 0.663342
MFAP5 microfibrillar associated protein 5 0.663342
MFAP4 microfibrillar-associated protein 4 0.663342
LAMC3 laminin, gamma 3 0.663342
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.663342
COL8A1 collagen, type VIII, alpha 1 0.663342
COL8A2 collagen, type VIII, alpha 2 0.663342
TNC tenascin C 0.663342
WNT3A wingless-type MMTV integration site family, member 3A 0.663342
MFAP1 microfibrillar-associated protein 1 0.663342
MFAP2 microfibrillar-associated protein 2 0.663342
WNT8B wingless-type MMTV integration site family, member 8B 0.663342
WNT8A wingless-type MMTV integration site family, member 8A 0.663342
FN1 fibronectin 1 0.663342
FBN2 fibrillin 2 0.663342
VCAN versican 0.663342
ANG angiogenin, ribonuclease, RNase A family, 5 0.663342
VEGFA vascular endothelial growth factor A 0.663342
TECTB tectorin beta 0.663342
TECTA tectorin alpha 0.663342
COL7A1 collagen, type VII, alpha 1 0.663342
COL4A6 collagen, type IV, alpha 6 0.663342
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.663342
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 0.663342
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.663342
MMP23B matrix metallopeptidase 23B 0.663342
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.663342
MMP26 matrix metallopeptidase 26 0.663342
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.663342
MMP25 matrix metallopeptidase 25 0.663342
MMP28 matrix metallopeptidase 28 0.663342
BMP4 bone morphogenetic protein 4 0.663342
ENAM enamelin 0.663342
COL4A5 collagen, type IV, alpha 5 0.663342
MATN1 matrilin 1, cartilage matrix protein 0.663342
IMPG2 interphotoreceptor matrix proteoglycan 2 0.663342
CRISP3 cysteine-rich secretory protein 3 0.663342
FMOD fibromodulin 0.663342
BCAN brevican 0.663342
EMID1 EMI domain containing 1 0.663342
LAMA3 laminin, alpha 3 0.663342
EMILIN1 elastin microfibril interfacer 1 0.663342
BGN biglycan 0.663342
COL17A1 collagen, type XVII, alpha 1 0.663342
LAMA2 laminin, alpha 2 0.663342
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.663342
COMP cartilage oligomeric matrix protein 0.663342
LAMA1 laminin, alpha 1 0.663342
LAMB4 laminin, beta 4 0.663342
HPSE2 heparanase 2 (inactive) 0.663342
LAMB2 laminin, beta 2 (laminin S) 0.663342
LAMA4 laminin, alpha 4 0.663342
LAMA5 laminin, alpha 5 0.663342
COL9A1 collagen, type IX, alpha 1 0.663342
MUC4 mucin 4, cell surface associated 0.663342
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.663342
THBS4 thrombospondin 4 0.663342
WNT16 wingless-type MMTV integration site family, member 16 0.663342
COL1A2 collagen, type I, alpha 2 0.663342
EMILIN2 elastin microfibril interfacer 2 0.663342
RPTN repetin 0.663342
NID1 nidogen 1 0.663342
NID2 nidogen 2 (osteonidogen) 0.663342
COL6A1 collagen, type VI, alpha 1 0.663342
FBN1 fibrillin 1 0.663342
COL27A1 collagen, type XXVII, alpha 1 0.663342
FLRT3 fibronectin leucine rich transmembrane protein 3 0.663342
FLRT1 fibronectin leucine rich transmembrane protein 1 0.663342
WNT7A wingless-type MMTV integration site family, member 7A 0.663342
LAMB3 laminin, beta 3 0.663342
WNT7B wingless-type MMTV integration site family, member 7B 0.663342
WNT6 wingless-type MMTV integration site family, member 6 0.663342
MEPE matrix extracellular phosphoglycoprotein 0.663342
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.663342
FLRT2 fibronectin leucine rich transmembrane protein 2 0.663342
WNT4 wingless-type MMTV integration site family, member 4 0.663342
COL14A1 collagen, type XIV, alpha 1 0.663342
WNT1 wingless-type MMTV integration site family, member 1 0.663342
WNT2 wingless-type MMTV integration site family member 2 0.663342
WNT3 wingless-type MMTV integration site family, member 3 0.663342
LECT1 leukocyte cell derived chemotaxin 1 0.663342
SFTPA1 surfactant protein A1 0.663342
TNN tenascin N 0.663342
SFTPA2 surfactant protein A2 0.663342
TNR tenascin R 0.663342
TNXB tenascin XB 0.663342
WNT10B wingless-type MMTV integration site family, member 10B 0.663342
COL13A1 collagen, type XIII, alpha 1 0.663342
DCN decorin 0.663342
KERA keratocan 0.663342
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.663342
WNT10A wingless-type MMTV integration site family, member 10A 0.663342
LAMB1 laminin, beta 1 0.663342
CD248 CD248 molecule, endosialin 0.663342
WNT9B wingless-type MMTV integration site family, member 9B 0.663342
HSPG2 heparan sulfate proteoglycan 2 0.663342
TINAG tubulointerstitial nephritis antigen 0.663342
PI3 peptidase inhibitor 3, skin-derived 0.237908
CTGF connective tissue growth factor 0.237908
COL9A2 collagen, type IX, alpha 2 0.237908
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 0.237908
COL16A1 collagen, type XVI, alpha 1 0.237908
COL2A1 collagen, type II, alpha 1 0.237908
COL9A3 collagen, type IX, alpha 3 0.237908
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.237908
MGP matrix Gla protein 0.237908
OPTC opticin 0.237908
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.237908
GPC1 glypican 1 0.237908
FBLN5 fibulin 5 0.237908
TGFB1 transforming growth factor, beta 1 0.237908
COL3A1 collagen, type III, alpha 1 0.237908
TFPI2 tissue factor pathway inhibitor 2 0.237908
POSTN periostin, osteoblast specific factor 0.237908
IMPG1 interphotoreceptor matrix proteoglycan 1 0.237908
COL1A1 collagen, type I, alpha 1 0.237908
COL10A1 collagen, type X, alpha 1 0.237908
ACHE acetylcholinesterase (Yt blood group) 0.237908
DMP1 dentin matrix acidic phosphoprotein 1 0.237908
MMP11 matrix metallopeptidase 11 0.237908
MMP10 matrix metallopeptidase 10 0.237908
DGCR6 DiGeorge syndrome critical region gene 6 0.237908
DST dystonin 0.237908
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.237908
LTBP2 latent transforming growth factor beta binding protein 2 0.237908
COL5A1 collagen, type V, alpha 1 0.237908
SMC3 structural maintenance of chromosomes 3 0.237908
COL5A2 collagen, type V, alpha 2 0.237908
ERBB2IP erbb2 interacting protein 0.237908
COL6A3 collagen, type VI, alpha 3 0.237908
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.237908
LOXL2 lysyl oxidase-like 2 0.237908
ANOS1 anosmin 1 0.237908
COL18A1 collagen, type XVIII, alpha 1 0.237908
P3H2 prolyl 3-hydroxylase 2 0.237908
APLP1 amyloid beta (A4) precursor-like protein 1 0.237908
SFRP1 secreted frizzled-related protein 1 0.237908
MATN3 matrilin 3 0.237908
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.237908
HAPLN3 hyaluronan and proteoglycan link protein 3 0.098109
COL20A1 collagen, type XX, alpha 1 0.098109
ADIPOQ adiponectin, C1Q and collagen domain containing 0.098109
C1QTNF7 C1q and tumor necrosis factor related protein 7 0.098109
NPNT nephronectin 0.098109
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.098109
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.098109
COL6A6 collagen, type VI, alpha 6 0.098109
COLEC12 collectin sub-family member 12 0.098109
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 0.098109
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 0.098109
HAPLN2 hyaluronan and proteoglycan link protein 2 0.098109
C1QTNF2 C1q and tumor necrosis factor related protein 2 0.098109
C1QTNF8 C1q and tumor necrosis factor related protein 8 0.098109
SPARCL1 SPARC-like 1 (hevin) 0.098109
C1QL4 complement component 1, q subcomponent-like 4 0.098109
C1QL3 complement component 1, q subcomponent-like 3 0.098109
C1QL2 complement component 1, q subcomponent-like 2 0.098109
MFRP membrane frizzled-related protein 0.098109
C1QTNF3 C1q and tumor necrosis factor related protein 3 0.098109
C1QTNF1 C1q and tumor necrosis factor related protein 1 0.098109
COL23A1 collagen, type XXIII, alpha 1 0.098109
HMCN2 hemicentin 2 0.098109
CTHRC1 collagen triple helix repeat containing 1 0.098109
C1QTNF9B C1q and tumor necrosis factor related protein 9B 0.098109
CHADL chondroadherin-like 0.098109
C1QA complement component 1, q subcomponent, A chain 0.098109
P3H1 prolyl 3-hydroxylase 1 0.098109
HMCN1 hemicentin 1 0.098109
SCARA3 scavenger receptor class A, member 3 0.098109
TFF3 trefoil factor 3 (intestinal) 0.098109
MBL2 mannose-binding lectin (protein C) 2, soluble 0.098109
C1QC complement component 1, q subcomponent, C chain 0.098109
SMOC1 SPARC related modular calcium binding 1 0.098109
SMOC2 SPARC related modular calcium binding 2 0.098109
CILP2 cartilage intermediate layer protein 2 0.098109
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.098109
ZG16 zymogen granule protein 16 0.098109
EGFL6 EGF-like-domain, multiple 6 0.098109
C1QL1 complement component 1, q subcomponent-like 1 0.098109
COLEC10 collectin sub-family member 10 (C-type lectin) 0.098109
COLEC11 collectin sub-family member 11 0.098109
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.098109
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.098109
OTOA otoancorin 0.098109
WDR33 WD repeat domain 33 0.098109
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.098109
UCMA upper zone of growth plate and cartilage matrix associated 0.098109
COL24A1 collagen, type XXIV, alpha 1 0.098109
EDA ectodysplasin A 0.098109
AMTN amelotin 0.098109
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.098109
MMP9 matrix metallopeptidase 9 0.098109
MMP8 matrix metallopeptidase 8 0.098109
COCH cochlin 0.098109
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 0.098109
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.098109
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 0.098109
FCN3 ficolin (collagen/fibrinogen domain containing) 3 0.098109
OMD osteomodulin 0.098109
LAD1 ladinin 1 0.098109
MMP7 matrix metallopeptidase 7 0.098109
MMP3 matrix metallopeptidase 3 0.098109
MMP1 matrix metallopeptidase 1 0.098109
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.098109
PXDN peroxidasin 0.098109
MMP13 matrix metallopeptidase 13 0.098109
MMP12 matrix metallopeptidase 12 0.098109
ANXA2 annexin A2 0.098109
ACAN aggrecan 0.098109
CHAD chondroadherin 0.098109
VWC2 von Willebrand factor C domain containing 2 0.098109
COL22A1 collagen, type XXII, alpha 1 0.098109
CPZ carboxypeptidase Z 0.098109
EPYC epiphycan 0.098109
C1QTNF9 C1q and tumor necrosis factor related protein 9 0.098109
NTN4 netrin 4 0.098109
NTN3 netrin 3 0.098109
VWF von Willebrand factor 0.098109
FBN3 fibrillin 3 0.098109
CALR calreticulin 0.098109
NYX nyctalopin 0.098109
GLDN gliomedin 0.098109
MARCO macrophage receptor with collagenous structure 0.098109
MSR1 macrophage scavenger receptor 1 0.098109
RELN reelin 0.098109
COL6A2 collagen, type VI, alpha 2 0.098109
COL28A1 collagen, type XXVIII, alpha 1 0.098109
DPT dermatopontin 0.098109
COL21A1 collagen, type XXI, alpha 1 0.098109
CRTAC1 cartilage acidic protein 1 0.098109
CPA6 carboxypeptidase A6 0.098109
VWA1 von Willebrand factor A domain containing 1 0.098109
CRTAP cartilage associated protein 0.098109
EMILIN3 elastin microfibril interfacer 3 0.098109
COL6A5 collagen, type VI, alpha 5 0.098109
SBSPON somatomedin B and thrombospondin, type 1 domain containing 0.098109
CHL1 cell adhesion molecule L1-like 0.098109
FREM3 FRAS1 related extracellular matrix 3 0.098109
CCBE1 collagen and calcium binding EGF domains 1 0.098109
ANGPTL4 angiopoietin-like 4 0.098109
FBLN7 fibulin 7 0.098109
PODNL1 podocan-like 1 0.098109
OGN osteoglycin 0.098109
LGALS1 lectin, galactoside-binding, soluble, 1 0.098109
BMP1 bone morphogenetic protein 1 0.098109
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.098109
ADAMTSL1 ADAMTS-like 1 0.098109
MMP27 matrix metallopeptidase 27 0.098109
ADAMTSL3 ADAMTS-like 3 0.098109
PRSS36 protease, serine, 36 0.098109
HAPLN4 hyaluronan and proteoglycan link protein 4 0.098109
C1QB complement component 1, q subcomponent, B chain 0.098109
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 0.098109
SPON1 spondin 1, extracellular matrix protein 0.098109
MMP20 matrix metallopeptidase 20 0.098109
SPON2 spondin 2, extracellular matrix protein 0.098109
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 0.098109
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.098109
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.098109
COL25A1 collagen, type XXV, alpha 1 0.098109
FREM1 FRAS1 related extracellular matrix 1 0.098109
OTOL1 otolin 1 0.098109
SOST sclerostin 0.098109
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 0.098109
GFOD2 glucose-fructose oxidoreductase domain containing 2 0.098109
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.098109
OTOG otogelin 0.03318
ITGB4 integrin, beta 4 0.03318
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.03318
TIMP1 TIMP metallopeptidase inhibitor 1 0.03318
C6ORF15 chromosome 6 open reading frame 15 0.03318
ADAMTSL4 ADAMTS-like 4 0.03318
GPC5 glypican 5 0.03318
GPC6 glypican 6 0.03318
GPC3 glypican 3 0.03318
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.03318
GPC2 glypican 2 0.03318
NTN1 netrin 1 0.03318
VWA2 von Willebrand factor A domain containing 2 0.03318
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.03318
GPC4 glypican 4 0.03318
THBS2 thrombospondin 2 0.03318
FREM2 FRAS1 related extracellular matrix protein 2 0.03318
ADAMTSL2 ADAMTS-like 2 0.03318
CST3 cystatin C 0.03318
DMBT1 deleted in malignant brain tumors 1 0.03318
TFIP11 tuftelin interacting protein 11 0.03318
ALB albumin 0.03318
RELL2 RELT-like 2 0.03318
TIMP2 TIMP metallopeptidase inhibitor 2 0.03318
TGFBR3 transforming growth factor, beta receptor III 0.03318
FGF9 fibroblast growth factor 9 0.03318
CCDC80 coiled-coil domain containing 80 0.03318
VIT vitrin 0.03318
DLG1 discs, large homolog 1 (Drosophila) 0.03318
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.03318
PAPLN papilin, proteoglycan-like sulfated glycoprotein 0.03318
LOXL1 lysyl oxidase-like 1 0.03318
MMRN2 multimerin 2 0.03318
NAV2 neuron navigator 2 0.03318
EGFLAM EGF-like, fibronectin type III and laminin G domains 0.03318
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 0.03318
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.03318
ABI3BP ABI family, member 3 (NESH) binding protein 0.03318
SEBOX SEBOX homeobox 0.03318
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 0.03318
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.03318
THSD4 thrombospondin, type I, domain containing 4 0.03318
MAMDC2 MAM domain containing 2 0.03318
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.03318
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.03318
ITGA6 integrin, alpha 6 0.03318
LGALS3 lectin, galactoside-binding, soluble, 3 0.03318
SPN sialophorin 0.03318
RUNX1 runt-related transcription factor 1 0.03318
LOX lysyl oxidase 0.03318