protein catabolic process Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. (Gene Ontology, GO_0030163)
External Link http://amigo.geneontology.org/amigo/term/GO:0030163
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Genes

338 genes participating in the protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMBP alpha-1-microglobulin/bikunin precursor
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC11 anaphase promoting complex subunit 11
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
APC adenomatous polyposis coli
APOB apolipoprotein B
APOE apolipoprotein E
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATG7 autophagy related 7
ATM ATM serine/threonine kinase
ATXN3 ataxin 3
ATXN3L ataxin 3-like
AURKA aurora kinase A
AURKB aurora kinase B
AXIN1 axin 1
BFAR bifunctional apoptosis regulator
BIRC2 baculoviral IAP repeat containing 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
C2ORF40 chromosome 2 open reading frame 40
CCNB1 cyclin B1
CCNF cyclin F
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CDC34 cell division cycle 34
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CLN3 ceroid-lipofuscinosis, neuronal 3
CLN5 ceroid-lipofuscinosis, neuronal 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CLOCK clock circadian regulator
CPA2 carboxypeptidase A2 (pancreatic)
CRBN cereblon
CUL1 cullin 1
CUL3 cullin 3
CUL4A cullin 4A
DAB2IP DAB2 interacting protein
DDB1 damage-specific DNA binding protein 1, 127kDa
DDIT3 DNA-damage-inducible transcript 3
DENND3 DENN/MADD domain containing 3
DERL1 derlin 1
DERL2 derlin 2
DERL3 derlin 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ERCC8 excision repair cross-complementation group 8
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
FAF1 Fas (TNFRSF6) associated factor 1
FBXL15 F-box and leucine-rich repeat protein 15
FBXL19 F-box and leucine-rich repeat protein 19
FBXL2 F-box and leucine-rich repeat protein 2
FBXL3 F-box and leucine-rich repeat protein 3
FBXL5 F-box and leucine-rich repeat protein 5
FBXL7 F-box and leucine-rich repeat protein 7
FBXO2 F-box protein 2
FBXO31 F-box protein 31
FBXO4 F-box protein 4
FBXO45 F-box protein 45
FBXO5 F-box protein 5
FBXO6 F-box protein 6
FBXO9 F-box protein 9
FBXW11 F-box and WD repeat domain containing 11
FBXW5 F-box and WD repeat domain containing 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FBXW9 F-box and WD repeat domain containing 9
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GPC1 glypican 1
GSK3A glycogen synthase kinase 3 alpha
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HPSE heparanase
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTRA2 HtrA serine peptidase 2
IDE insulin-degrading enzyme
JKAMP JNK1/MAPK8-associated membrane protein
KAT5 K(lysine) acetyltransferase 5
KCTD10 potassium channel tetramerization domain containing 10
KCTD13 potassium channel tetramerization domain containing 13
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KIF14 kinesin family member 14
KLHL20 kelch-like family member 20
KLHL42 kelch-like family member 42
KLK4 kallikrein-related peptidase 4
LDLR low density lipoprotein receptor
LNPEP leucyl/cystinyl aminopeptidase
LRSAM1 leucine rich repeat and sterile alpha motif containing 1
LYPLA1 lysophospholipase I
LYPLAL1 lysophospholipase-like 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEC2 melanoma antigen family C2
MAN1B1 mannosidase, alpha, class 1B, member 1
MANBA mannosidase, beta A, lysosomal
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP20 matrix metallopeptidase 20
MMP3 matrix metallopeptidase 3
MTA1 metastasis associated 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEK2 NIMA-related kinase 2
NEU4 sialidase 4
NFE2L2 nuclear factor, erythroid 2-like 2
NGLY1 N-glycanase 1
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NR1D1 nuclear receptor subfamily 1, group D, member 1
NSFL1C NSFL1 (p97) cofactor (p47)
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARK2 parkin RBR E3 ubiquitin protein ligase
PCBP2 poly(rC) binding protein 2
PCNP PEST proteolytic signal containing nuclear protein
PCSK9 proprotein convertase subtilisin/kexin type 9
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPT1 palmitoyl-protein thioesterase 1
PRPF19 pre-mRNA processing factor 19
PRSS16 protease, serine, 16 (thymus)
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSME4 proteasome (prosome, macropain) activator subunit 4
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTTG1 pituitary tumor-transforming 1
RAB12 RAB12, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RHBDD1 rhomboid domain containing 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF103 ring finger protein 103
RNF121 ring finger protein 121
RNF126 ring finger protein 126
RNF175 ring finger protein 175
RNF187 ring finger protein 187
RNF216 ring finger protein 216
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RNF4 ring finger protein 4
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPS27A ribosomal protein S27a
SDF2L1 stromal cell-derived factor 2-like 1
SEC61B Sec61 beta subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOCS6 suppressor of cytokine signaling 6
SPATA18 spermatogenesis associated 18
SPOP speckle-type POZ protein
SPOPL speckle-type POZ protein-like
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TMEM67 transmembrane protein 67
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TOR1A torsin family 1, member A (torsin A)
TPP1 tripeptidyl peptidase I
TRAF2 TNF receptor-associated factor 2
TRIM13 tripartite motif containing 13
TRIM24 tripartite motif containing 24
TRIM38 tripartite motif containing 38
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TRIM9 tripartite motif containing 9
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2A ubiquitin-conjugating enzyme E2A
UBE2B ubiquitin-conjugating enzyme E2B
UBE2C ubiquitin-conjugating enzyme E2C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2G1 ubiquitin-conjugating enzyme E2G 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2I ubiquitin-conjugating enzyme E2I
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2J2 ubiquitin-conjugating enzyme E2, J2
UBE2K ubiquitin-conjugating enzyme E2K
UBE2R2 ubiquitin-conjugating enzyme E2R 2
UBE2S ubiquitin-conjugating enzyme E2S
UBE2U ubiquitin-conjugating enzyme E2U (putative)
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBE4B ubiquitination factor E4B
UBXN1 UBX domain protein 1
UBXN11 UBX domain protein 11
UBXN2A UBX domain protein 2A
UBXN2B UBX domain protein 2B
UBXN8 UBX domain protein 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
USP1 ubiquitin specific peptidase 1
USP10 ubiquitin specific peptidase 10
USP11 ubiquitin specific peptidase 11
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP15 ubiquitin specific peptidase 15
USP16 ubiquitin specific peptidase 16
USP17L10 ubiquitin specific peptidase 17-like family member 10
USP17L11 ubiquitin specific peptidase 17-like family member 11
USP17L12 ubiquitin specific peptidase 17-like family member 12
USP17L13 ubiquitin specific peptidase 17-like family member 13
USP17L17 ubiquitin specific peptidase 17-like family member 17
USP17L18 ubiquitin specific peptidase 17-like family member 18
USP17L19 ubiquitin specific peptidase 17-like family member 19
USP17L2 ubiquitin specific peptidase 17-like family member 2
USP17L20 ubiquitin specific peptidase 17-like family member 20
USP17L21 ubiquitin specific peptidase 17-like family member 21
USP17L22 ubiquitin specific peptidase 17-like family member 22
USP17L5 ubiquitin specific peptidase 17-like family member 5
USP18 ubiquitin specific peptidase 18
USP19 ubiquitin specific peptidase 19
USP2 ubiquitin specific peptidase 2
USP20 ubiquitin specific peptidase 20
USP21 ubiquitin specific peptidase 21
USP22 ubiquitin specific peptidase 22
USP24 ubiquitin specific peptidase 24
USP25 ubiquitin specific peptidase 25
USP26 ubiquitin specific peptidase 26
USP28 ubiquitin specific peptidase 28
USP29 ubiquitin specific peptidase 29
USP3 ubiquitin specific peptidase 3
USP30 ubiquitin specific peptidase 30
USP31 ubiquitin specific peptidase 31
USP32 ubiquitin specific peptidase 32
USP33 ubiquitin specific peptidase 33
USP34 ubiquitin specific peptidase 34
USP35 ubiquitin specific peptidase 35
USP36 ubiquitin specific peptidase 36
USP37 ubiquitin specific peptidase 37
USP38 ubiquitin specific peptidase 38
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP40 ubiquitin specific peptidase 40
USP42 ubiquitin specific peptidase 42
USP43 ubiquitin specific peptidase 43
USP44 ubiquitin specific peptidase 44
USP45 ubiquitin specific peptidase 45
USP47 ubiquitin specific peptidase 47
USP48 ubiquitin specific peptidase 48
USP49 ubiquitin specific peptidase 49
USP51 ubiquitin specific peptidase 51
USP6 ubiquitin specific peptidase 6
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP8 ubiquitin specific peptidase 8
USP9X ubiquitin specific peptidase 9, X-linked
USP9Y ubiquitin specific peptidase 9, Y-linked
VCP valosin containing protein
VIMP VCP-interacting membrane selenoprotein
WFS1 Wolfram syndrome 1 (wolframin)
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
WWTR1 WW domain containing transcription regulator 1
YOD1 YOD1 deubiquitinase
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase