propylthiouracil-4157 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the propylthiouracil-4157 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADAM12 ADAM metallopeptidase domain 12
ADAM23 ADAM metallopeptidase domain 23
ADAM8 ADAM metallopeptidase domain 8
ADGRE2 adhesion G protein-coupled receptor E2
ADGRE3 adhesion G protein-coupled receptor E3
ADGRG1 adhesion G protein-coupled receptor G1
AIM1L absent in melanoma 1-like
ALB albumin
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANG angiogenin, ribonuclease, RNase A family, 5
ARMCX4 armadillo repeat containing, X-linked 4
ASCL1 achaete-scute family bHLH transcription factor 1
BHMT2 betaine--homocysteine S-methyltransferase 2
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF1 chromosome 14 open reading frame 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CARD10 caspase recruitment domain family, member 10
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CCKAR cholecystokinin A receptor
CD7 CD7 molecule
CD96 CD96 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH5 cadherin 5, type 2 (vascular endothelium)
CFAP69 cilia and flagella associated protein 69
CNTLN centlein, centrosomal protein
CXORF21 chromosome X open reading frame 21
CYB5R2 cytochrome b5 reductase 2
DMPK dystrophia myotonica-protein kinase
DVL2 dishevelled segment polarity protein 2
ELMO1 engulfment and cell motility 1
EPHB1 EPH receptor B1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM149B1 family with sequence similarity 149, member B1
FAM182B family with sequence similarity 182, member B
FAM49B family with sequence similarity 49, member B
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGB fibrinogen beta chain
FZD10 frizzled class receptor 10
GRK5 G protein-coupled receptor kinase 5
GRM8 glutamate receptor, metabotropic 8
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL7R interleukin 7 receptor
ITGA7 integrin, alpha 7
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KRT17 keratin 17, type I
KRT38 keratin 38, type I
LBP lipopolysaccharide binding protein
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MBD2 methyl-CpG binding domain protein 2
MCAM melanoma cell adhesion molecule
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MTMR7 myotubularin related protein 7
MTSS1L metastasis suppressor 1-like
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NR6A1 nuclear receptor subfamily 6, group A, member 1
NTF3 neurotrophin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXF2 nuclear RNA export factor 2
PADI3 peptidyl arginine deiminase, type III
PARVB parvin, beta
PDAP1 PDGFA associated protein 1
PKNOX2 PBX/knotted 1 homeobox 2
PLAT plasminogen activator, tissue
POU1F1 POU class 1 homeobox 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKCA protein kinase C, alpha
PRKG2 protein kinase, cGMP-dependent, type II
PRODH2 proline dehydrogenase (oxidase) 2
PRPH2 peripherin 2 (retinal degeneration, slow)
PRR16 proline rich 16
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RGS9 regulator of G-protein signaling 9
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SH2D2A SH2 domain containing 2A
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SNED1 sushi, nidogen and EGF-like domains 1
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPTB spectrin, beta, erythrocytic
SYT2 synaptotagmin II
TMPRSS6 transmembrane protease, serine 6
TRIM29 tripartite motif containing 29
TRPC3 transient receptor potential cation channel, subfamily C, member 3
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
WRNIP1 Werner helicase interacting protein 1
XCR1 chemokine (C motif) receptor 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF407 zinc finger protein 407

decreased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AHDC1 AT hook, DNA binding motif, containing 1
AHNAK2 AHNAK nucleoprotein 2
ANKH ANKH inorganic pyrophosphate transport regulator
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOLD1 apolipoprotein L domain containing 1
ARHGAP4 Rho GTPase activating protein 4
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
B9D2 B9 protein domain 2
BCL6 B-cell CLL/lymphoma 6
C17ORF53 chromosome 17 open reading frame 53
C1ORF105 chromosome 1 open reading frame 105
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAMK4 calcium/calmodulin-dependent protein kinase IV
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX8 chromobox homolog 8
CCDC69 coiled-coil domain containing 69
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK18 cyclin-dependent kinase 18
CPEB3 cytoplasmic polyadenylation element binding protein 3
CRY2 cryptochrome circadian clock 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DNM3 dynamin 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM120C family with sequence similarity 120C
FAM131A family with sequence similarity 131, member A
FAM155A family with sequence similarity 155, member A
FAM184A family with sequence similarity 184, member A
FAM76A family with sequence similarity 76, member A
FGD6 FYVE, RhoGEF and PH domain containing 6
FRMD1 FERM domain containing 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GBP2 guanylate binding protein 2, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GK3P glycerol kinase 3 pseudogene
GRTP1 growth hormone regulated TBC protein 1
H2AFY2 H2A histone family, member Y2
HIST1H3E histone cluster 1, H3e
HIST1H4F histone cluster 1, H4f
HIST2H2AA3 histone cluster 2, H2aa3
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXA4 homeobox A4
HOXC10 homeobox C10
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIF13A kinesin family member 13A
KLK5 kallikrein-related peptidase 5
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LOC729164 hCG1732469
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPKBP1 mitogen-activated protein kinase binding protein 1
MOB3B MOB kinase activator 3B
MRPL41 mitochondrial ribosomal protein L41
MTCP1 mature T-cell proliferation 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NIPAL2 NIPA-like domain containing 2
NRSN2 neurensin 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PCDHB3 protocadherin beta 3
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCD1 phospholipase C, delta 1
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF122 ring finger protein 122
RNF208 ring finger protein 208
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPL10L ribosomal protein L10-like
RUNDC3B RUN domain containing 3B
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMIM14 small integral membrane protein 14
SNTA1 syntrophin, alpha 1
SPARCL1 SPARC-like 1 (hevin)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TBC1D19 TBC1 domain family, member 19
TFF2 trefoil factor 2
TMEM184C transmembrane protein 184C
TMPRSS2 transmembrane protease, serine 2
TRAIP TRAF interacting protein
TRIM36 tripartite motif containing 36
TTC4 tetratricopeptide repeat domain 4
VEGFB vascular endothelial growth factor B
VN1R1 vomeronasal 1 receptor 1
ZNF551 zinc finger protein 551
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675