pronetalol-4104 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the pronetalol-4104 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAM12 ADAM metallopeptidase domain 12
ADAM29 ADAM metallopeptidase domain 29
ADAM7 ADAM metallopeptidase domain 7
ADCK2 aarF domain containing kinase 2
AHNAK2 AHNAK nucleoprotein 2
APOH apolipoprotein H (beta-2-glycoprotein I)
ATXN2L ataxin 2-like
BCL3 B-cell CLL/lymphoma 3
C5AR2 complement component 5a receptor 2
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC68 coiled-coil domain containing 68
CD58 CD58 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPQ carboxypeptidase Q
CUL3 cullin 3
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCTN2 dynactin 2 (p50)
DEPDC5 DEP domain containing 5
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DPH5 diphthamide biosynthesis 5
DSG3 desmoglein 3
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFNB3 ephrin-B3
ELOVL2 ELOVL fatty acid elongase 2
ELSPBP1 epididymal sperm binding protein 1
EN1 engrailed homeobox 1
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLOT1 flotillin 1
FRZB frizzled-related protein
FSCN3 fascin actin-bundling protein 3, testicular
FXYD5 FXYD domain containing ion transport regulator 5
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAS7 growth arrest-specific 7
GFI1 growth factor independent 1 transcription repressor
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPR143 G protein-coupled receptor 143
GRM1 glutamate receptor, metabotropic 1
GSTM5 glutathione S-transferase mu 5
HCG4 HLA complex group 4 (non-protein coding)
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
ICOS inducible T-cell co-stimulator
IGF1R insulin-like growth factor 1 receptor
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LAMC2 laminin, gamma 2
LOXL3 lysyl oxidase-like 3
MAL mal, T-cell differentiation protein
MAPK7 mitogen-activated protein kinase 7
MATN3 matrilin 3
MMP13 matrix metallopeptidase 13
MORC1 MORC family CW-type zinc finger 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYL10 myosin, light chain 10, regulatory
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PAPPA2 pappalysin 2
PCNX pecanex homolog (Drosophila)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLLP plasmolipin
PLXNA2 plexin A2
PRKCQ protein kinase C, theta
PTHLH parathyroid hormone-like hormone
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RND1 Rho family GTPase 1
RPL14 ribosomal protein L14
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSU1 Ras suppressor protein 1
SECTM1 secreted and transmembrane 1
SH3BP2 SH3-domain binding protein 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC35E2 solute carrier family 35, member E2
SLC39A9 solute carrier family 39, member 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STS steroid sulfatase (microsomal), isozyme S
SUGP1 SURP and G patch domain containing 1
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SYNE1 spectrin repeat containing, nuclear envelope 1
SYP synaptophysin
SYT11 synaptotagmin XI
TBC1D2 TBC1 domain family, member 2
TCF3 transcription factor 3
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TMEM144 transmembrane protein 144
TRIM38 tripartite motif containing 38
TSC22D4 TSC22 domain family, member 4
UBOX5 U-box domain containing 5
VSIG4 V-set and immunoglobulin domain containing 4
WSCD1 WSC domain containing 1
ZBTB7A zinc finger and BTB domain containing 7A
ZNF318 zinc finger protein 318
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABHD4 abhydrolase domain containing 4
ACTL8 actin-like 8
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
BMP15 bone morphogenetic protein 15
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C11ORF63 chromosome 11 open reading frame 63
CBX8 chromobox homolog 8
CCDC85C coiled-coil domain containing 85C
CCNT1 cyclin T1
CDADC1 cytidine and dCMP deaminase domain containing 1
CDHR2 cadherin-related family member 2
CGA glycoprotein hormones, alpha polypeptide
CHST10 carbohydrate sulfotransferase 10
CPA4 carboxypeptidase A4
CRIP1 cysteine-rich protein 1 (intestinal)
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUZD1 CUB and zona pellucida-like domains 1
CYHR1 cysteine/histidine-rich 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF13 DDB1 and CUL4 associated factor 13
DCAF16 DDB1 and CUL4 associated factor 16
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELP6 elongator acetyltransferase complex subunit 6
FKBP10 FK506 binding protein 10, 65 kDa
GINS4 GINS complex subunit 4 (Sld5 homolog)
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST1H3E histone cluster 1, H3e
HIST1H4C histone cluster 1, H4c
HIST1H4F histone cluster 1, H4f
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXB2 homeobox B2
IFI6 interferon, alpha-inducible protein 6
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5C lysine (K)-specific demethylase 5C
LRP2 low density lipoprotein receptor-related protein 2
MFSD11 major facilitator superfamily domain containing 11
MGC12488
MIS18BP1 MIS18 binding protein 1
MYL5 myosin, light chain 5, regulatory
NAT6 N-acetyltransferase 6 (GCN5-related)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCDHGB5 protocadherin gamma subfamily B, 5
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POMT2 protein-O-mannosyltransferase 2
PRR14L proline rich 14-like
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PRSS53 protease, serine, 53
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFX7 regulatory factor X, 7
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
RPL10L ribosomal protein L10-like
SAMD9 sterile alpha motif domain containing 9
SKA1 spindle and kinetochore associated complex subunit 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMAD5 SMAD family member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPRYD7 SPRY domain containing 7
STK16 serine/threonine kinase 16
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAOK1 TAO kinase 1
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEP1 telomerase-associated protein 1
TET3 tet methylcytosine dioxygenase 3
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM19 transmembrane protein 19
TMEM209 transmembrane protein 209
TRIM16 tripartite motif containing 16
TUBA3D tubulin, alpha 3d
USP36 ubiquitin specific peptidase 36
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VASP vasodilator-stimulated phosphoprotein
VGF VGF nerve growth factor inducible
VIM vimentin
XDH xanthine dehydrogenase
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF134 zinc finger protein 134
ZNF652 zinc finger protein 652
ZNF74 zinc finger protein 74
ZNF747 zinc finger protein 747