proglumide-3861 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the proglumide-3861 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACBD4 acyl-CoA binding domain containing 4
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ACVR1B activin A receptor, type IB
ADGRG1 adhesion G protein-coupled receptor G1
ADM2 adrenomedullin 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARSD arylsulfatase D
ATP11A ATPase, class VI, type 11A
ATRX alpha thalassemia/mental retardation syndrome X-linked
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3ORF18 chromosome 3 open reading frame 18
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CDK14 cyclin-dependent kinase 14
CDKN2A cyclin-dependent kinase inhibitor 2A
CFHR4 complement factor H-related 4
COPA coatomer protein complex, subunit alpha
CUZD1 CUB and zona pellucida-like domains 1
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DAPK3 death-associated protein kinase 3
DENND6B DENN/MADD domain containing 6B
DST dystonin
ESR1 estrogen receptor 1
FAIM2 Fas apoptotic inhibitory molecule 2
FAM174B family with sequence similarity 174, member B
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FUS FUS RNA binding protein
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GHRHR growth hormone releasing hormone receptor
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GTF2I general transcription factor IIi
HDAC7 histone deacetylase 7
HHIPL2 HHIP-like 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1L hematological and neurological expressed 1-like
HTATSF1 HIV-1 Tat specific factor 1
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL17RC interleukin 17 receptor C
ITGB6 integrin, beta 6
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLHL25 kelch-like family member 25
KMT2A lysine (K)-specific methyltransferase 2A
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MARK1 MAP/microtubule affinity-regulating kinase 1
MCL1 myeloid cell leukemia 1
MED16 mediator complex subunit 16
MEF2D myocyte enhancer factor 2D
METTL16 methyltransferase like 16
MFSD6 major facilitator superfamily domain containing 6
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MRPL41 mitochondrial ribosomal protein L41
NIPAL2 NIPA-like domain containing 2
NPM3 nucleophosmin/nucleoplasmin 3
NUP188 nucleoporin 188kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGFR opioid growth factor receptor
ORAI2 ORAI calcium release-activated calcium modulator 2
PCDHGA3 protocadherin gamma subfamily A, 3
PDAP1 PDGFA associated protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCH1 phospholipase C, eta 1
POM121 POM121 transmembrane nucleoporin
POPDC3 popeye domain containing 3
POU5F1B POU class 5 homeobox 1B
PQLC2 PQ loop repeat containing 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBBP9 retinoblastoma binding protein 9
RBM5 RNA binding motif protein 5
RNF6 ring finger protein (C3H2C3 type) 6
RUNX1 runt-related transcription factor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SORT1 sortilin 1
SPO11 SPO11 meiotic protein covalently bound to DSB
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STX16 syntaxin 16
TAS2R1 taste receptor, type 2, member 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMLHE trimethyllysine hydroxylase, epsilon
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TPP1 tripeptidyl peptidase I
TRIM25 tripartite motif containing 25
TWF1 twinfilin actin binding protein 1
UBOX5 U-box domain containing 5
UCN urocortin
VEGFA vascular endothelial growth factor A
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WNT16 wingless-type MMTV integration site family, member 16
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANKH ANKH inorganic pyrophosphate transport regulator
ANP32A-IT1 ANP32A intronic transcript 1
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
AXIN1 axin 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
C4BPA complement component 4 binding protein, alpha
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CEP72 centrosomal protein 72kDa
CORO7 coronin 7
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAH17 dynein, axonemal, heavy chain 17
DNM1 dynamin 1
DOC2A double C2-like domains, alpha
DSCAM Down syndrome cell adhesion molecule
DUSP2 dual specificity phosphatase 2
DUSP9 dual specificity phosphatase 9
EFCAB2 EF-hand calcium binding domain 2
EFNA3 ephrin-A3
ELP6 elongator acetyltransferase complex subunit 6
EMCN endomucin
EMID1 EMI domain containing 1
EPHB6 EPH receptor B6
ETV6 ets variant 6
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF4 fibroblast growth factor 4
FHOD1 formin homology 2 domain containing 1
FLJ11710 uncharacterized protein FLJ11710
FOXI1 forkhead box I1
FXYD5 FXYD domain containing ion transport regulator 5
GLB1L galactosidase, beta 1-like
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GUSBP3 glucuronidase, beta pseudogene 3
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H1B histone cluster 1, H1b
HIST1H4C histone cluster 1, H4c
HIST1H4D histone cluster 1, H4d
IL22 interleukin 22
INO80D INO80 complex subunit D
ITPKB inositol-trisphosphate 3-kinase B
KCTD7 potassium channel tetramerization domain containing 7
LHX1 LIM homeobox 1
MED15 mediator complex subunit 15
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MRPL2 mitochondrial ribosomal protein L2
MYBBP1A MYB binding protein (P160) 1a
NDRG4 NDRG family member 4
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
NXPE3 neurexophilin and PC-esterase domain family, member 3
OSGIN1 oxidative stress induced growth inhibitor 1
PACS1 phosphofurin acidic cluster sorting protein 1
PORCN porcupine homolog (Drosophila)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RPL10L ribosomal protein L10-like
SHB Src homology 2 domain containing adaptor protein B
SKI SKI proto-oncogene
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SND1-IT1 SND1 intronic transcript 1
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
TBC1D2 TBC1 domain family, member 2
TET3 tet methylcytosine dioxygenase 3
TFF2 trefoil factor 2
THRAP3 thyroid hormone receptor associated protein 3
TLN1 talin 1
TMEM39B transmembrane protein 39B
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNS2 tensin 2
TRDMT1 tRNA aspartic acid methyltransferase 1
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
VIM vimentin
VPS9D1 VPS9 domain containing 1
WFDC2 WAP four-disulfide core domain 2
XYLT2 xylosyltransferase II
ZBED1 zinc finger, BED-type containing 1
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF286A zinc finger protein 286A
ZNF358 zinc finger protein 358
ZNF41 zinc finger protein 41
ZNF446 zinc finger protein 446
ZNF74 zinc finger protein 74
ZNF804A zinc finger protein 804A
ZNF862 zinc finger protein 862