prochlorperazine-995 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the prochlorperazine-995 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALOX15 arachidonate 15-lipoxygenase
ANXA1 annexin A1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
AQP3 aquaporin 3 (Gill blood group)
ARHGAP35 Rho GTPase activating protein 35
ATF3 activating transcription factor 3
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BDKRB2 bradykinin receptor B2
BHLHE40 basic helix-loop-helix family, member e40
C16ORF45 chromosome 16 open reading frame 45
C17ORF59 chromosome 17 open reading frame 59
CA11 carbonic anhydrase XI
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CBX8 chromobox homolog 8
CCNG2 cyclin G2
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEMIP cell migration inducing protein, hyaluronan binding
CEP164 centrosomal protein 164kDa
CGA glycoprotein hormones, alpha polypeptide
CHPF chondroitin polymerizing factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
DUSP4 dual specificity phosphatase 4
DVL2 dishevelled segment polarity protein 2
E2F5 E2F transcription factor 5, p130-binding
EGR1 early growth response 1
FADS3 fatty acid desaturase 3
FKBP14 FK506 binding protein 14, 22 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN8 gem (nuclear organelle) associated protein 8
GK3P glycerol kinase 3 pseudogene
GLRX glutaredoxin (thioltransferase)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HFE hemochromatosis
HIPK2 homeodomain interacting protein kinase 2
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BJ histone cluster 1, H2bj
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL27RA interleukin 27 receptor, alpha
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LYRM9 LYR motif containing 9
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK11 mitogen-activated protein kinase 11
MAX MYC associated factor X
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
NDRG1 N-myc downstream regulated 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OASL 2'-5'-oligoadenylate synthetase-like
OSGIN1 oxidative stress induced growth inhibitor 1
OTUD4 OTU deubiquitinase 4
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM5 PDZ and LIM domain 5
PEX16 peroxisomal biogenesis factor 16
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRLR prolactin receptor
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PRSS16 protease, serine, 16 (thymus)
RPS3A ribosomal protein S3A
SAT1 spermidine/spermine N1-acetyltransferase 1
SFXN3 sideroflexin 3
SH3BP2 SH3-domain binding protein 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SRCAP Snf2-related CREBBP activator protein
SSBP3 single stranded DNA binding protein 3
SUGP1 SURP and G patch domain containing 1
SUN1 Sad1 and UNC84 domain containing 1
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPYL2 TSPY-like 2
VEGFA vascular endothelial growth factor A
VIPR1 vasoactive intestinal peptide receptor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YIPF4 Yip1 domain family, member 4
ZNF204P zinc finger protein 204, pseudogene
ZNF350 zinc finger protein 350
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACTN4 actinin, alpha 4
ACVR2A activin A receptor, type IIA
AKAP12 A kinase (PRKA) anchor protein 12
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATP13A2 ATPase type 13A2
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1ORF56 chromosome 1 open reading frame 56
C22ORF29 chromosome 22 open reading frame 29
CCDC15 coiled-coil domain containing 15
CCNE1 cyclin E1
CDCA4 cell division cycle associated 4
CENPB centromere protein B, 80kDa
CENPC centromere protein C
CIDEC cell death-inducing DFFA-like effector c
CLIP4 CAP-GLY domain containing linker protein family, member 4
CLSPN claspin
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DOCK1 dedicator of cytokinesis 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
E2F8 E2F transcription factor 8
EIF5A2 eukaryotic translation initiation factor 5A2
FAM155B family with sequence similarity 155, member B
FAM188A family with sequence similarity 188, member A
FAM50B family with sequence similarity 50, member B
FAM86C1 family with sequence similarity 86, member C1
FBRS fibrosin
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GRTP1 growth hormone regulated TBC protein 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXC11 homeobox C11
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
INCENP inner centromere protein antigens 135/155kDa
ITPKB inositol-trisphosphate 3-kinase B
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KCTD20 potassium channel tetramerization domain containing 20
KRT86 keratin 86, type II
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LOC100287590 uncharacterized LOC100287590
LOC257152 uncharacterized LOC257152
LOC730101 uncharacterized LOC730101
LRRC61 leucine rich repeat containing 61
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MANSC1 MANSC domain containing 1
MAP1S microtubule-associated protein 1S
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK12 mitogen-activated protein kinase 12
NAP1L2 nucleosome assembly protein 1-like 2
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NKAIN1 Na+/K+ transporting ATPase interacting 1
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NRGN neurogranin (protein kinase C substrate, RC3)
OTUD3 OTU deubiquitinase 3
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAQR3 progestin and adipoQ receptor family member III
PCDHA6 protocadherin alpha 6
PCDHB3 protocadherin beta 3
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGS1 phosphatidylglycerophosphate synthase 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR15L proline rich 15-like
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBM14 RNA binding motif protein 14
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SGK1 serum/glucocorticoid regulated kinase 1
SH3GL1 SH3-domain GRB2-like 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNRPF small nuclear ribonucleoprotein polypeptide F
STARD5 StAR-related lipid transfer (START) domain containing 5
STRN striatin, calmodulin binding protein
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYT17 synaptotagmin XVII
TBC1D31 TBC1 domain family, member 31
TTLL1 tubulin tyrosine ligase-like family member 1
UBXN8 UBX domain protein 8
VASH1 vasohibin 1
WDR4 WD repeat domain 4
WDR60 WD repeat domain 60
XK X-linked Kx blood group
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB3 zinc finger and BTB domain containing 3
ZMAT5 zinc finger, matrin-type 5
ZNF557 zinc finger protein 557