prochlorperazine-6975 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the prochlorperazine-6975 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP3 aquaporin 3 (Gill blood group)
AURKA aurora kinase A
BCAS1 breast carcinoma amplified sequence 1
BMP1 bone morphogenetic protein 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C14ORF93 chromosome 14 open reading frame 93
C16ORF45 chromosome 16 open reading frame 45
CCNG2 cyclin G2
CD58 CD58 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CGA glycoprotein hormones, alpha polypeptide
CNN1 calponin 1, basic, smooth muscle
CTNS cystinosin, lysosomal cystine transporter
DRD2 dopamine receptor D2
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM110B family with sequence similarity 110, member B
FAM212B family with sequence similarity 212, member B
FASTKD2 FAST kinase domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
GAB1 GRB2-associated binding protein 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GSTA4 glutathione S-transferase alpha 4
HBB hemoglobin, beta
HIPK2 homeodomain interacting protein kinase 2
HIST1H2BO histone cluster 1, H2bo
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HYI hydroxypyruvate isomerase (putative)
IGHM immunoglobulin heavy constant mu
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LAMB3 laminin, beta 3
LHX1 LIM homeobox 1
LONP2 lon peptidase 2, peroxisomal
LPIN1 lipin 1
LRP5L low density lipoprotein receptor-related protein 5-like
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAPT microtubule-associated protein tau
MED12 mediator complex subunit 12
MED6 mediator complex subunit 6
MTMR3 myotubularin related protein 3
MTRF1L mitochondrial translational release factor 1-like
MZF1 myeloid zinc finger 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NEURL1 neuralized E3 ubiquitin protein ligase 1
OSMR oncostatin M receptor
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
QKI QKI, KH domain containing, RNA binding
RGS12 regulator of G-protein signaling 12
RHO rhodopsin
RNASEH2B ribonuclease H2, subunit B
RNF126P1 ring finger protein 126 pseudogene 1
RPGRIP1L RPGRIP1-like
RRBP1 ribosome binding protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SFXN3 sideroflexin 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SQSTM1 sequestosome 1
SRCAP Snf2-related CREBBP activator protein
SSPN sarcospan
STX2 syntaxin 2
SYBU syntabulin (syntaxin-interacting)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TACC1 transforming, acidic coiled-coil containing protein 1
TET3 tet methylcytosine dioxygenase 3
TMCC2 transmembrane and coiled-coil domain family 2
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRIM2 tripartite motif containing 2
TTLL3 tubulin tyrosine ligase-like family member 3
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WAS Wiskott-Aldrich syndrome
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF117 zinc finger protein 117
ZNF16 zinc finger protein 16
ZNF250 zinc finger protein 250
ZNF37BP zinc finger protein 37B, pseudogene
ZNF500 zinc finger protein 500
ZNF767P zinc finger family member 767, pseudogene
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ADRA2C adrenoceptor alpha 2C
AHCTF1 AT hook containing transcription factor 1
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASB9 ankyrin repeat and SOCS box containing 9
ATAD3A ATPase family, AAA domain containing 3A
AXIN1 axin 1
BBS10 Bardet-Biedl syndrome 10
BPGM 2,3-bisphosphoglycerate mutase
C1ORF35 chromosome 1 open reading frame 35
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAPN15 calpain 15
CDC7 cell division cycle 7
CENPB centromere protein B, 80kDa
CHD8 chromodomain helicase DNA binding protein 8
CHKB choline kinase beta
CLSPN claspin
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DSN1 DSN1, MIS12 kinetochore complex component
DTX4 deltex 4, E3 ubiquitin ligase
DUS2 dihydrouridine synthase 2
EFCAB2 EF-hand calcium binding domain 2
EYA2 EYA transcriptional coactivator and phosphatase 2
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBP10 FK506 binding protein 10, 65 kDa
FOXD1 forkhead box D1
FZD4 frizzled class receptor 4
GALT galactose-1-phosphate uridylyltransferase
GATAD2A GATA zinc finger domain containing 2A
GHR growth hormone receptor
GPR19 G protein-coupled receptor 19
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAUS6 HAUS augmin-like complex, subunit 6
HINFP histone H4 transcription factor
HMHA1 histocompatibility (minor) HA-1
HRAS Harvey rat sarcoma viral oncogene homolog
ILKAP integrin-linked kinase-associated serine/threonine phosphatase
IP6K1 inositol hexakisphosphate kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
KIAA0895 KIAA0895
KLHL21 kelch-like family member 21
LINC00115 long intergenic non-protein coding RNA 115
LMNB1 lamin B1
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MANEA mannosidase, endo-alpha
MBOAT2 membrane bound O-acyltransferase domain containing 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL16 methyltransferase like 16
METTL2B methyltransferase like 2B
METTL4 methyltransferase like 4
MMP9 matrix metallopeptidase 9
MOCS2 molybdenum cofactor synthesis 2
MORC3 MORC family CW-type zinc finger 3
MXD3 MAX dimerization protein 3
MYO1E myosin IE
NCAM2 neural cell adhesion molecule 2
NCAPH non-SMC condensin I complex, subunit H
NDRG4 NDRG family member 4
NES nestin
NOTCH1 notch 1
NPY5R neuropeptide Y receptor Y5
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PADI2 peptidyl arginine deiminase, type II
PARD6A par-6 family cell polarity regulator alpha
PEX12 peroxisomal biogenesis factor 12
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHLDA3 pleckstrin homology-like domain, family A, member 3
PKN1 protein kinase N1
PLD3 phospholipase D family, member 3
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SFT2D2 SFT2 domain containing 2
SLC16A6 solute carrier family 16, member 6
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNIP1 Smad nuclear interacting protein 1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SUSD4 sushi domain containing 4
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TMEM115 transmembrane protein 115
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSSC4 tumor suppressing subtransferable candidate 4
TTC27 tetratricopeptide repeat domain 27
URM1 ubiquitin related modifier 1
VGF VGF nerve growth factor inducible
WRAP73 WD repeat containing, antisense to TP73
ZC3H3 zinc finger CCCH-type containing 3
ZNF253 zinc finger protein 253
ZNF254 zinc finger protein 254
ZNF552 zinc finger protein 552
ZNF623 zinc finger protein 623
ZNF668 zinc finger protein 668