prochlorperazine-4439 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the prochlorperazine-4439 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALOXE3 arachidonate lipoxygenase 3
AMIGO2 adhesion molecule with Ig-like domain 2
ARTN artemin
ATF3 activating transcription factor 3
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
C22ORF46 chromosome 22 open reading frame 46
CA2 carbonic anhydrase II
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CDO1 cysteine dioxygenase type 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEMIP cell migration inducing protein, hyaluronan binding
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
COL16A1 collagen, type XVI, alpha 1
CTBP2 C-terminal binding protein 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKFZP434C153 DKFZP434C153 protein
DMRT1 doublesex and mab-3 related transcription factor 1
DOK4 docking protein 4
DUSP1 dual specificity phosphatase 1
EGR2 early growth response 2
ETV1 ets variant 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GK glycerol kinase
GLI2 GLI family zinc finger 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H3I histone cluster 1, H3i
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HUS1 HUS1 checkpoint homolog (S. pombe)
ICOSLG inducible T-cell co-stimulator ligand
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JUND jun D proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF13 Kruppel-like factor 13
KLF3 Kruppel-like factor 3 (basic)
KLHL18 kelch-like family member 18
KLHL24 kelch-like family member 24
KRT16 keratin 16, type I
LAPTM5 lysosomal protein transmembrane 5
LINC00260 long intergenic non-protein coding RNA 260
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGEA5 melanoma antigen family A5
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
NDNF neuron-derived neurotrophic factor
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NPTXR neuronal pentraxin receptor
NUPR1 nuclear protein, transcriptional regulator, 1
PDE8B phosphodiesterase 8B
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPARA peroxisome proliferator-activated receptor alpha
PRAMEF10 PRAME family member 10
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS4 regulator of G-protein signaling 4
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RND1 Rho family GTPase 1
SH3BP2 SH3-domain binding protein 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNX29 sorting nexin 29
SQSTM1 sequestosome 1
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYT1 synaptotagmin I
TAS2R1 taste receptor, type 2, member 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBKBP1 TBK1 binding protein 1
TEP1 telomerase-associated protein 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAPPC9 trafficking protein particle complex 9
TRIB3 tribbles pseudokinase 3
VPS9D1 VPS9 domain containing 1
ZBTB20 zinc finger and BTB domain containing 20
ZFP36L2 ZFP36 ring finger protein-like 2
ZFP64 ZFP64 zinc finger protein
ZFPL1 zinc finger protein-like 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF165 zinc finger protein 165
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
AGMAT agmatine ureohydrolase (agmatinase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
AOC2 amine oxidase, copper containing 2 (retina-specific)
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAK1 BCL2-antagonist/killer 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
C1ORF105 chromosome 1 open reading frame 105
C1QTNF3 C1q and tumor necrosis factor related protein 3
CASZ1 castor zinc finger 1
CCNE2 cyclin E2
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD82 CD82 molecule
CDC25A cell division cycle 25A
CFAP45 cilia and flagella associated protein 45
CNTLN centlein, centrosomal protein
COL9A3 collagen, type IX, alpha 3
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DENND2D DENN/MADD domain containing 2D
DPY19L1P1 DPY19L1 pseudogene 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDAR ectodysplasin A receptor
ENO3 enolase 3 (beta, muscle)
FBXO22 F-box protein 22
FMOD fibromodulin
FRMD1 FERM domain containing 1
FRS2 fibroblast growth factor receptor substrate 2
GLB1L2 galactosidase, beta 1-like 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2BM histone cluster 1, H2bm
HIST1H4C histone cluster 1, H4c
HSF2BP heat shock transcription factor 2 binding protein
IFNA14 interferon, alpha 14
IL22 interleukin 22
INCENP inner centromere protein antigens 135/155kDa
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
JMJD4 jumonji domain containing 4
KIRREL kin of IRRE like (Drosophila)
KLHL29 kelch-like family member 29
KLHL36 kelch-like family member 36
LEFTY1 left-right determination factor 1
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRP3 low density lipoprotein receptor-related protein 3
LRRC6 leucine rich repeat containing 6
LYRM9 LYR motif containing 9
MCM10 minichromosome maintenance complex component 10
METTL16 methyltransferase like 16
MGP matrix Gla protein
MNX1 motor neuron and pancreas homeobox 1
MTA2 metastasis associated 1 family, member 2
MX1 MX dynamin-like GTPase 1
MXRA8 matrix-remodelling associated 8
NAG18 NAG18 mRNA
NEUROD4 neuronal differentiation 4
NME5 NME/NM23 family member 5
NPY1R neuropeptide Y receptor Y1
NTSR1 neurotensin receptor 1 (high affinity)
OGDHL oxoglutarate dehydrogenase-like
OLFML2B olfactomedin-like 2B
ORC1 origin recognition complex, subunit 1
PARP6 poly (ADP-ribose) polymerase family, member 6
PDE12 phosphodiesterase 12
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PITX2 paired-like homeodomain 2
PLA1A phospholipase A1 member A
PQLC2 PQ loop repeat containing 2
PRKG2 protein kinase, cGMP-dependent, type II
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SCN10A sodium channel, voltage gated, type X alpha subunit
SELL selectin L
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SMO smoothened, frizzled class receptor
SOSTDC1 sclerostin domain containing 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTBN2 spectrin, beta, non-erythrocytic 2
STXBP6 syntaxin binding protein 6 (amisyn)
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYCP2 synaptonemal complex protein 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TIAM2 T-cell lymphoma invasion and metastasis 2
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
UGT8 UDP glycosyltransferase 8
VAV1 vav 1 guanine nucleotide exchange factor
VN1R1 vomeronasal 1 receptor 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF205 zinc finger protein 205
ZNF280B zinc finger protein 280B
ZNF528 zinc finger protein 528
ZNF76 zinc finger protein 76