procarbazine-3533 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the procarbazine-3533 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADAM22 ADAM metallopeptidase domain 22
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF6B activating transcription factor 6 beta
BMP6 bone morphogenetic protein 6
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1ORF54 chromosome 1 open reading frame 54
C3 complement component 3
CADM3 cell adhesion molecule 3
CCDC132 coiled-coil domain containing 132
CCDC28B coiled-coil domain containing 28B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDRT1 CMT1A duplicated region transcript 1
CELF3 CUGBP, Elav-like family member 3
COLEC12 collectin sub-family member 12
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22
DCN decorin
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DIAPH2-AS1 DIAPH2 antisense RNA 1
DICER1 dicer 1, ribonuclease type III
DYSF dysferlin
ECE1 endothelin converting enzyme 1
ENO3 enolase 3 (beta, muscle)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPS8L1 EPS8-like 1
ESR1 estrogen receptor 1
FABP7 fatty acid binding protein 7, brain
FGF18 fibroblast growth factor 18
FN1 fibronectin 1
FOXN3 forkhead box N3
GJA9 gap junction protein, alpha 9, 59kDa
GLB1L galactosidase, beta 1-like
GPR176 G protein-coupled receptor 176
GRM1 glutamate receptor, metabotropic 1
GSK3A glycogen synthase kinase 3 alpha
GZMM granzyme M (lymphocyte met-ase 1)
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP7 insulin-like growth factor binding protein 7
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL24 interleukin 24
INVS inversin
IPCEF1 interaction protein for cytohesin exchange factors 1
JAM3 junctional adhesion molecule 3
KLK7 kallikrein-related peptidase 7
KRT12 keratin 12, type I
KRT17 keratin 17, type I
LAT2 linker for activation of T cells family, member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LUZP4 leucine zipper protein 4
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MTMR8 myotubularin related protein 8
NABP1 nucleic acid binding protein 1
NKX2-2 NK2 homeobox 2
NMT2 N-myristoyltransferase 2
ONECUT1 one cut homeobox 1
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OSBPL10 oxysterol binding protein-like 10
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PKD2L2 polycystic kidney disease 2-like 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PSG3 pregnancy specific beta-1-glycoprotein 3
PTCRA pre T-cell antigen receptor alpha
PWAR5 Prader Willi/Angelman region RNA 5
PXDC1 PX domain containing 1
RAB35 RAB35, member RAS oncogene family
RGS4 regulator of G-protein signaling 4
RPH3A rabphilin 3A
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SARM1 sterile alpha and TIR motif containing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SDC2 syndecan 2
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SLIT2 slit homolog 2 (Drosophila)
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNX13 sorting nexin 13
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAOK2 TAO kinase 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCF20 transcription factor 20 (AR1)
THBS3 thrombospondin 3
TNC tenascin C
TRIM14 tripartite motif containing 14
TSPAN2 tetraspanin 2
TUBA4B tubulin, alpha 4b
TYRP1 tyrosinase-related protein 1
UPK1B uroplakin 1B
WDR55 WD repeat domain 55
ZNF44 zinc finger protein 44

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACYP2 acylphosphatase 2, muscle type
ANKRD36 ankyrin repeat domain 36
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB1 arrestin, beta 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BAG4 BCL2-associated athanogene 4
BAK1 BCL2-antagonist/killer 1
C11ORF80 chromosome 11 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
C7ORF43 chromosome 7 open reading frame 43
CCDC25 coiled-coil domain containing 25
CCNO cyclin O
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CGA glycoprotein hormones, alpha polypeptide
CHRM3 cholinergic receptor, muscarinic 3
CORT cortistatin
CTC1 CTS telomere maintenance complex component 1
CXCR2 chemokine (C-X-C motif) receptor 2
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
ECSIT ECSIT signalling integrator
ELMO3 engulfment and cell motility 3
ERCC5 excision repair cross-complementation group 5
FAM46C family with sequence similarity 46, member C
FBXL15 F-box and leucine-rich repeat protein 15
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPATCH3 G patch domain containing 3
HIST1H2BO histone cluster 1, H2bo
HIST2H2AA3 histone cluster 2, H2aa3
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
INPP5J inositol polyphosphate-5-phosphatase J
IRF1 interferon regulatory factor 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0125 KIAA0125
KIAA0895 KIAA0895
KLF3 Kruppel-like factor 3 (basic)
KLHL25 kelch-like family member 25
LAMB2 laminin, beta 2 (laminin S)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIN7A lin-7 homolog A (C. elegans)
LIN7B lin-7 homolog B (C. elegans)
LMCD1 LIM and cysteine-rich domains 1
LOC730101 uncharacterized LOC730101
LRP3 low density lipoprotein receptor-related protein 3
MAN2C1 mannosidase, alpha, class 2C, member 1
MATK megakaryocyte-associated tyrosine kinase
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFAP2 microfibrillar-associated protein 2
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NMRK1 nicotinamide riboside kinase 1
NPFFR1 neuropeptide FF receptor 1
NT5DC3 5'-nucleotidase domain containing 3
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD3 phospholipase D family, member 3
PMVK phosphomevalonate kinase
PROS1 protein S (alpha)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PYCRL pyrroline-5-carboxylate reductase-like
RAB33B RAB33B, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RECQL4 RecQ protein-like 4
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF170 ring finger protein 170
RPAP1 RNA polymerase II associated protein 1
RUSC2 RUN and SH3 domain containing 2
SAYSD1 SAYSVFN motif domain containing 1
SH2B3 SH2B adaptor protein 3
SH2D4A SH2 domain containing 4A
SKA1 spindle and kinetochore associated complex subunit 1
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SOWAHC sosondowah ankyrin repeat domain family member C
SPIDR scaffolding protein involved in DNA repair
SSPN sarcospan
STX1A syntaxin 1A (brain)
THOP1 thimet oligopeptidase 1
TMEM115 transmembrane protein 115
TMPRSS2 transmembrane protease, serine 2
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPAN5 tetraspanin 5
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBQLN4 ubiquilin 4
UROS uroporphyrinogen III synthase
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
WLS wntless Wnt ligand secretion mediator
ZNF250 zinc finger protein 250
ZNF324 zinc finger protein 324
ZNF652 zinc finger protein 652
ZNF675 zinc finger protein 675