probucol-4666 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the probucol-4666 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ADGRB2 adhesion G protein-coupled receptor B2
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP44 Rho GTPase activating protein 44
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATXN2L ataxin 2-like
C10ORF10 chromosome 10 open reading frame 10
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CD5 CD5 molecule
CD58 CD58 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDH8 cadherin 8, type 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFAP45 cilia and flagella associated protein 45
CLTCL1 clathrin, heavy chain-like 1
COL6A1 collagen, type VI, alpha 1
CTSS cathepsin S
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DPF1 D4, zinc and double PHD fingers family 1
DSCC1 DNA replication and sister chromatid cohesion 1
DVL3 dishevelled segment polarity protein 3
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FASLG Fas ligand (TNF superfamily, member 6)
FBRS fibrosin
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPSM3 G-protein signaling modulator 3
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
HDAC6 histone deacetylase 6
HEMK1 HemK methyltransferase family member 1
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HSF1 heat shock transcription factor 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
INSR insulin receptor
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MEG3 maternally expressed 3 (non-protein coding)
MILR1 mast cell immunoglobulin-like receptor 1
MRAS muscle RAS oncogene homolog
NEURL1 neuralized E3 ubiquitin protein ligase 1
NPFF neuropeptide FF-amide peptide precursor
NPVF neuropeptide VF precursor
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSBPL7 oxysterol binding protein-like 7
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIDD1 p53-induced death domain protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLXNB3 plexin B3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSG9 pregnancy specific beta-1-glycoprotein 9
PVT1 Pvt1 oncogene (non-protein coding)
RNFT1 ring finger protein, transmembrane 1
RPS14 ribosomal protein S14
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SETD1A SET domain containing 1A
SH3D21 SH3 domain containing 21
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK3 serine/threonine kinase 3
STRA6 stimulated by retinoic acid 6
STX7 syntaxin 7
TAOK1 TAO kinase 1
TBL2 transducin (beta)-like 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THOC5 THO complex 5
TMEM144 transmembrane protein 144
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNS1 tensin 1
TRIM29 tripartite motif containing 29
TROVE2 TROVE domain family, member 2
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
VARS valyl-tRNA synthetase
VASH1 vasohibin 1
VPS9D1 VPS9 domain containing 1
VWA5A von Willebrand factor A domain containing 5A
WSB1 WD repeat and SOCS box containing 1
YIPF2 Yip1 domain family, member 2
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF268 zinc finger protein 268
ZNF34 zinc finger protein 34
ZNF391 zinc finger protein 391

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACADSB acyl-CoA dehydrogenase, short/branched chain
AFAP1 actin filament associated protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA2P3 annexin A2 pseudogene 3
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BTC betacellulin
C14ORF105 chromosome 14 open reading frame 105
CCNJL cyclin J-like
CD68 CD68 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDKL3 cyclin-dependent kinase-like 3
CEP112 centrosomal protein 112kDa
CNN1 calponin 1, basic, smooth muscle
CPZ carboxypeptidase Z
DAGLA diacylglycerol lipase, alpha
DBF4B DBF4 zinc finger B
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DENND4A DENN/MADD domain containing 4A
EDN1 endothelin 1
EN2 engrailed homeobox 2
FAM120C family with sequence similarity 120C
FBXO2 F-box protein 2
FER fer (fps/fes related) tyrosine kinase
GAS8 growth arrest-specific 8
GMPR guanosine monophosphate reductase
GPR1 G protein-coupled receptor 1
GPR27 G protein-coupled receptor 27
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H2BN histone cluster 1, H2bn
HOXA1 homeobox A1
HOXB9 homeobox B9
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFT140 intraflagellar transport 140
IL17RA interleukin 17 receptor A
IL20RA interleukin 20 receptor, alpha
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KRT20 keratin 20, type I
KRT8P12 keratin 8 pseudogene 12
LHFPL2 lipoma HMGIC fusion partner-like 2
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LINC00341 long intergenic non-protein coding RNA 341
LMO7 LIM domain 7
LOC157562 uncharacterized LOC157562
LOC257152 uncharacterized LOC257152
LRRK1 leucine-rich repeat kinase 1
LTC4S leukotriene C4 synthase
LY96 lymphocyte antigen 96
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MCMBP minichromosome maintenance complex binding protein
MDFI MyoD family inhibitor
MTSS1L metastasis suppressor 1-like
MX1 MX dynamin-like GTPase 1
MYOZ1 myozenin 1
NOTCH1 notch 1
NPFFR1 neuropeptide FF receptor 1
NTF3 neurotrophin 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PACS1 phosphofurin acidic cluster sorting protein 1
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH12 protocadherin 12
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
PLD2 phospholipase D2
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PRR14L proline rich 14-like
PRR4 proline rich 4 (lacrimal)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
ROM1 retinal outer segment membrane protein 1
SH2D2A SH2 domain containing 2A
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNHG3 small nucleolar RNA host gene 3
SPTBN2 spectrin, beta, non-erythrocytic 2
STAG3 stromal antigen 3
STEAP4 STEAP family member 4
SYT17 synaptotagmin XVII
TCTN2 tectonic family member 2
TESK2 testis-specific kinase 2
TMSB15A thymosin beta 15a
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TTLL7 tubulin tyrosine ligase-like family member 7
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF219 zinc finger protein 219
ZNF222 zinc finger protein 222
ZNF428 zinc finger protein 428
ZNF528 zinc finger protein 528
ZNF667 zinc finger protein 667
ZNF668 zinc finger protein 668
ZNF778 zinc finger protein 778
ZNF839 zinc finger protein 839