probenecid-4771 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the probenecid-4771 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACAN aggrecan
ACTN2 actinin, alpha 2
AHNAK2 AHNAK nucleoprotein 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALK anaplastic lymphoma receptor tyrosine kinase
ALS2CL ALS2 C-terminal like
ANGPTL2 angiopoietin-like 2
APOM apolipoprotein M
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BEGAIN brain-enriched guanylate kinase-associated
BTG2 BTG family, member 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1ORF54 chromosome 1 open reading frame 54
CADM3 cell adhesion molecule 3
CCDC87 coiled-coil domain containing 87
CCL27 chemokine (C-C motif) ligand 27
CCNT2 cyclin T2
CD47 CD47 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFLAR CASP8 and FADD-like apoptosis regulator
CIDEB cell death-inducing DFFA-like effector b
CLDN17 claudin 17
CLIC5 chloride intracellular channel 5
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CRY2 cryptochrome circadian clock 2
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTSF cathepsin F
DKFZP434L187 uncharacterized LOC26082
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
EFNA3 ephrin-A3
EML2 echinoderm microtubule associated protein like 2
FGF5 fibroblast growth factor 5
FGL1 fibrinogen-like 1
GGT1 gamma-glutamyltransferase 1
GPER1 G protein-coupled estrogen receptor 1
GRM4 glutamate receptor, metabotropic 4
GRPR gastrin-releasing peptide receptor
HAPLN1 hyaluronan and proteoglycan link protein 1
HCG4B HLA complex group 4B (non-protein coding)
HOXA4 homeobox A4
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
ICOSLG inducible T-cell co-stimulator ligand
IL11RA interleukin 11 receptor, alpha
IL1RN interleukin 1 receptor antagonist
INE1 inactivation escape 1 (non-protein coding)
INHBE inhibin, beta E
ITGB7 integrin, beta 7
ITPK1 inositol-tetrakisphosphate 1-kinase
KRT24 keratin 24, type I
LINC00472 long intergenic non-protein coding RNA 472
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MED25 mediator complex subunit 25
METTL7A methyltransferase like 7A
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MSR1 macrophage scavenger receptor 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCR2 natural cytotoxicity triggering receptor 2
NEURL1 neuralized E3 ubiquitin protein ligase 1
NF1 neurofibromin 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOD2 nucleotide-binding oligomerization domain containing 2
NPFFR1 neuropeptide FF receptor 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PITX1 paired-like homeodomain 1
PLLP plasmolipin
PML promyelocytic leukemia
POFUT1 protein O-fucosyltransferase 1
PRB1 proline-rich protein BstNI subfamily 1
PURG purine-rich element binding protein G
RAB11B RAB11B, member RAS oncogene family
REM1 RAS (RAD and GEM)-like GTP-binding 1
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RYR1 ryanodine receptor 1 (skeletal)
SARM1 sterile alpha and TIR motif containing 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SNAP23 synaptosomal-associated protein, 23kDa
SP100 SP100 nuclear antigen
SSTR4 somatostatin receptor 4
TCF3 transcription factor 3
TMEM63A transmembrane protein 63A
TRIO trio Rho guanine nucleotide exchange factor
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TSC22D4 TSC22 domain family, member 4
TUBA4B tubulin, alpha 4b
UPK3B uroplakin 3B
WNT10B wingless-type MMTV integration site family, member 10B
ZNF304 zinc finger protein 304
ZNF589 zinc finger protein 589
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALPK1 alpha-kinase 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ARL15 ADP-ribosylation factor-like 15
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASB8 ankyrin repeat and SOCS box containing 8
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AUH AU RNA binding protein/enoyl-CoA hydratase
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BBC3 BCL2 binding component 3
BCOR BCL6 corepressor
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CAMKMT calmodulin-lysine N-methyltransferase
CENPE centromere protein E, 312kDa
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COCH cochlin
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like
CPE carboxypeptidase E
DAAM1 dishevelled associated activator of morphogenesis 1
DCLRE1A DNA cross-link repair 1A
DEPDC1 DEP domain containing 1
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAL4 dynein, axonemal, light chain 4
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELOVL4 ELOVL fatty acid elongase 4
FGGY FGGY carbohydrate kinase domain containing
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBP10 FK506 binding protein 10, 65 kDa
FURIN furin (paired basic amino acid cleaving enzyme)
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GCC1 GRIP and coiled-coil domain containing 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMCL1 germ cell-less, spermatogenesis associated 1
GMEB1 glucocorticoid modulatory element binding protein 1
GRAMD4 GRAM domain containing 4
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H3G histone cluster 1, H3g
HSPA1L heat shock 70kDa protein 1-like
JMJD1C jumonji domain containing 1C
KIF23 kinesin family member 23
LMNB1 lamin B1
MAGEF1 melanoma antigen family F1
MANBA mannosidase, beta A, lysosomal
MANEA mannosidase, endo-alpha
MDN1 MDN1, midasin homolog (yeast)
MEX3C mex-3 RNA binding family member C
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYL5 myosin, light chain 5, regulatory
NCAM2 neural cell adhesion molecule 2
NLRX1 NLR family member X1
ODF2 outer dense fiber of sperm tails 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OTUD3 OTU deubiquitinase 3
OXCT1 3-oxoacid CoA transferase 1
PAQR3 progestin and adipoQ receptor family member III
PARP16 poly (ADP-ribose) polymerase family, member 16
PDGFA platelet-derived growth factor alpha polypeptide
PEX26 peroxisomal biogenesis factor 26
PLD3 phospholipase D family, member 3
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTK6 protein tyrosine kinase 6
PTPRU protein tyrosine phosphatase, receptor type, U
RARS arginyl-tRNA synthetase
RNF19B ring finger protein 19B
RNF25 ring finger protein 25
RSL24D1 ribosomal L24 domain containing 1
SCFD1 sec1 family domain containing 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SHCBP1 SHC SH2-domain binding protein 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNX16 sorting nexin 16
STBD1 starch binding domain 1
SUGP1 SURP and G patch domain containing 1
TGDS TDP-glucose 4,6-dehydratase
THAP1 THAP domain containing, apoptosis associated protein 1
TLN1 talin 1
TMBIM4 transmembrane BAX inhibitor motif containing 4
TMC7 transmembrane channel-like 7
TOE1 target of EGR1, member 1 (nuclear)
TRAPPC2 trafficking protein particle complex 2
TRIM52 tripartite motif containing 52
UNC119 unc-119 homolog (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
USP6NL USP6 N-terminal like
VCPKMT valosin containing protein lysine (K) methyltransferase
ZBED1 zinc finger, BED-type containing 1
ZC3H12A zinc finger CCCH-type containing 12A
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF573 zinc finger protein 573
ZNF652 zinc finger protein 652
ZNF7 zinc finger protein 7
ZNF83 zinc finger protein 83