probenecid-4185 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the probenecid-4185 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADA adenosine deaminase
AHCYL1 adenosylhomocysteinase-like 1
ALDOB aldolase B, fructose-bisphosphate
ANTXR1 anthrax toxin receptor 1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ATG10 autophagy related 10
ATP11A ATPase, class VI, type 11A
ATXN7L1 ataxin 7-like 1
BCAP29 B-cell receptor-associated protein 29
BCHE butyrylcholinesterase
BTD biotinidase
BTG2 BTG family, member 2
C17ORF53 chromosome 17 open reading frame 53
C1S complement component 1, s subcomponent
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CCDC186 coiled-coil domain containing 186
CCDC71 coiled-coil domain containing 71
CD34 CD34 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CES3 carboxylesterase 3
COL6A1 collagen, type VI, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CRAT carnitine O-acetyltransferase
CRYGD crystallin, gamma D
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYTH4 cytohesin 4
DEFA4 defensin, alpha 4, corticostatin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DZIP1 DAZ interacting zinc finger protein 1
EFR3B EFR3 homolog B (S. cerevisiae)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM63A family with sequence similarity 63, member A
FGF7 fibroblast growth factor 7
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FRMD4B FERM domain containing 4B
GK3P glycerol kinase 3 pseudogene
GLB1L galactosidase, beta 1-like
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR17 G protein-coupled receptor 17
GYG2 glycogenin 2
HBS1L HBS1-like translational GTPase
ICOSLG inducible T-cell co-stimulator ligand
IFITM1 interferon induced transmembrane protein 1
IL18R1 interleukin 18 receptor 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IRF4 interferon regulatory factor 4
KCTD14 potassium channel tetramerization domain containing 14
KYNU kynureninase
LAMP1 lysosomal-associated membrane protein 1
LRP4 low density lipoprotein receptor-related protein 4
LRRC8B leucine rich repeat containing 8 family, member B
MAPK11 mitogen-activated protein kinase 11
MCHR1 melanin-concentrating hormone receptor 1
MYL10 myosin, light chain 10, regulatory
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAAA N-acylethanolamine acid amidase
NAV3 neuron navigator 3
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NFRKB nuclear factor related to kappaB binding protein
NR1H4 nuclear receptor subfamily 1, group H, member 4
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PALMD palmdelphin
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PRDM2 PR domain containing 2, with ZNF domain
PRKCB protein kinase C, beta
PTPRU protein tyrosine phosphatase, receptor type, U
RAB36 RAB36, member RAS oncogene family
RPS14 ribosomal protein S14
RXRB retinoid X receptor, beta
SCARB1 scavenger receptor class B, member 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3D21 SH3 domain containing 21
SMO smoothened, frizzled class receptor
SND1-IT1 SND1 intronic transcript 1
SOS2 son of sevenless homolog 2 (Drosophila)
STON1 stonin 1
SUGP1 SURP and G patch domain containing 1
TAS2R10 taste receptor, type 2, member 10
TBRG4 transforming growth factor beta regulator 4
TLE4 transducin-like enhancer of split 4
TNIK TRAF2 and NCK interacting kinase
TNS1 tensin 1
TROVE2 TROVE domain family, member 2
TTLL4 tubulin tyrosine ligase-like family member 4
UBE2B ubiquitin-conjugating enzyme E2B
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZBTB20 zinc finger and BTB domain containing 20
ZC2HC1C zinc finger, C2HC-type containing 1C
ZMYM5 zinc finger, MYM-type 5
ZNF536 zinc finger protein 536
ZNF609 zinc finger protein 609
ZNF614 zinc finger protein 614

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ADAM2 ADAM metallopeptidase domain 2
ADAM23 ADAM metallopeptidase domain 23
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARPIN actin-related protein 2/3 complex inhibitor
ARRB2 arrestin, beta 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BTF3P12 basic transcription factor 3 pseudogene 12
C14ORF105 chromosome 14 open reading frame 105
C22ORF46 chromosome 22 open reading frame 46
C8A complement component 8, alpha polypeptide
CASS4 Cas scaffolding protein family member 4
CBX8 chromobox homolog 8
CD70 CD70 molecule
CISH cytokine inducible SH2-containing protein
CLTCL1 clathrin, heavy chain-like 1
CNN1 calponin 1, basic, smooth muscle
CORT cortistatin
CRYGC crystallin, gamma C
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DSPP dentin sialophosphoprotein
EBF2 early B-cell factor 2
FAM110B family with sequence similarity 110, member B
FKBP5 FK506 binding protein 5
FLJ21369 uncharacterized protein FLJ21369
FLT4 fms-related tyrosine kinase 4
FRMPD1 FERM and PDZ domain containing 1
FRS3 fibroblast growth factor receptor substrate 3
GIF gastric intrinsic factor (vitamin B synthesis)
GLS2 glutaminase 2 (liver, mitochondrial)
GSTA3 glutathione S-transferase alpha 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AJ histone cluster 1, H2aj
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFT140 intraflagellar transport 140
IRF9 interferon regulatory factor 9
ITGB7 integrin, beta 7
KANSL3 KAT8 regulatory NSL complex subunit 3
KRT20 keratin 20, type I
KRT86 keratin 86, type II
KRT8P12 keratin 8 pseudogene 12
LIME1 Lck interacting transmembrane adaptor 1
LPAR4 lysophosphatidic acid receptor 4
LRRK1 leucine-rich repeat kinase 1
LY6D lymphocyte antigen 6 complex, locus D
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MGP matrix Gla protein
MTA2 metastasis associated 1 family, member 2
MTSS1L metastasis suppressor 1-like
MXRA8 matrix-remodelling associated 8
MYO1D myosin ID
MYO1F myosin IF
MYOZ3 myozenin 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NARFL nuclear prelamin A recognition factor-like
NBEAL2 neurobeachin-like 2
NINJ1 ninjurin 1
NTSR1 neurotensin receptor 1 (high affinity)
ODF2 outer dense fiber of sperm tails 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBP2 oxysterol binding protein 2
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRB3 proline-rich protein BstNI subfamily 3
PRSS53 protease, serine, 53
RAPSN receptor-associated protein of the synapse
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RPP25 ribonuclease P/MRP 25kDa subunit
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1-IT1 RUNX1 intronic transcript 1
SCIN scinderin
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SOX21 SRY (sex determining region Y)-box 21
SPATA1 spermatogenesis associated 1
SPTBN2 spectrin, beta, non-erythrocytic 2
STEAP4 STEAP family member 4
TBC1D17 TBC1 domain family, member 17
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TLN1 talin 1
TMEM212 transmembrane protein 212
TMPRSS4 transmembrane protease, serine 4
TNRC6B trinucleotide repeat containing 6B
TPCN1 two pore segment channel 1
TRAF2 TNF receptor-associated factor 2
TTLL1 tubulin tyrosine ligase-like family member 1
UBQLN4 ubiquilin 4
VASP vasodilator-stimulated phosphoprotein
VGF VGF nerve growth factor inducible
VGLL3 vestigial-like family member 3
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF749 zinc finger protein 749